NeoGenesis Barrier Renewal Cream
The NeoGenesis Barrier Renewal Cream is a moisturizer booster designed to lock in hydration and strengthen the skin barrier, preventing transepidermal water loss (TEWL). Formulated with the perfect balance of ceramides and cholesterol-free fatty acids, this lightweight yet powerful finishing layer helps seal in moisture for long-lasting hydration and improved skin resilience.
Designed to be used over your favorite hydrating moisturizer, this barrier-fortifying cream is ideal for dry, sensitive, rosacea-prone, and compromised skin. With regular use, it supports skin repair, reduces irritation, and enhances firmness, making it a must-have for moisture retention and overall skin health.
- Boosts hydration retention by sealing in moisture
- Strengthens and repairs the skin barrier to prevent moisture loss
- Provides essential ceramides and lipids for long-term resilience
- Lightweight, non-greasy formula, perfect as a finishing layer
- Unscented and oncology-approved, safe for even the most sensitive skin
30 mL | Airless Pump
120 mL or 5 mL | Pump
For optimal hydration and barrier support, layer the NeoGenesis Barrier Renewal Cream over your daily moisturizer to lock in moisture and keep skin healthy, balanced, and protected.
After cleansing, toning, and applying a hydrating mist, serum, or moisturizer, apply NeoGenesis Barrier Renewal Cream to the face, neck, and chest in the morning and evening to lock in hydration and strengthen the skin barrier.
- Ceramide NP: Improves the skin's hydration and texture and prevents dryness and irritation. It is stable and compatible with the skin, making it an effective choice for topical application.
- Ceramide AP: A shorter chain length compared to other ceramide types and is considered more effective in restoring and strengthening the skin's barrier.
- Ceramide EOP: The most abundant ceramide type in the skin's barrier. It helps to maintain the skin's hydration and prevent water loss.
- Ceramide Trio: Together, these ceramide types work synergistically to support the skin's barrier function and overall health.
- Phytosphingosine: Enhances the skin's barrier function. Its antimicrobial and anti-inflammatory properties make it particularly effective in treating acneic skin.
- Sodium Hyaluronate: The purest, salt form of hyaluronic acid, a master humectant that holds up to 1,000 times its weight in water to provide maximum hydration and plumping benefits to thirsty skin.
Water, Carthamus Tinctorius (Safflower) Oleosomes, Urea, Squalane, Caprylic/Capric Triglyceride, Glycerin, Sodium PCA, Sodium Acrylates Copolymer, Lecithin, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Sodium Hyaluronate Butyrate, Panthenol, Sodium Hyaluronate, Chondrus Crispus Extract, Propanediol, Dehydroacetic Acid, Benzyl Alcohol.
NeoGenesis Barrier Renewal Cream – The Ultimate Moisture Lock Booster
- Unit price
- /per

Primary Concerns:
- Compromised Barrier
- Dehydration
- Dryness
- Dullness
- Redness/Rosacea

Best For:
- Dry
- Normal
- Sensitive
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NeoGenesis Barrier Renewal Cream
The NeoGenesis Barrier Renewal Cream is a moisturizer booster designed to lock in hydration and strengthen the skin barrier, preventing transepidermal water loss (TEWL). Formulated with the perfect balance of ceramides and cholesterol-free fatty acids, this lightweight yet powerful finishing layer helps seal in moisture for long-lasting hydration and improved skin resilience.
Designed to be used over your favorite hydrating moisturizer, this barrier-fortifying cream is ideal for dry, sensitive, rosacea-prone, and compromised skin. With regular use, it supports skin repair, reduces irritation, and enhances firmness, making it a must-have for moisture retention and overall skin health.
- Boosts hydration retention by sealing in moisture
- Strengthens and repairs the skin barrier to prevent moisture loss
- Provides essential ceramides and lipids for long-term resilience
- Lightweight, non-greasy formula, perfect as a finishing layer
- Unscented and oncology-approved, safe for even the most sensitive skin
30 mL | Airless Pump
120 mL or 5 mL | Pump
For optimal hydration and barrier support, layer the NeoGenesis Barrier Renewal Cream over your daily moisturizer to lock in moisture and keep skin healthy, balanced, and protected.
After cleansing, toning, and applying a hydrating mist, serum, or moisturizer, apply NeoGenesis Barrier Renewal Cream to the face, neck, and chest in the morning and evening to lock in hydration and strengthen the skin barrier.
- Ceramide NP: Improves the skin's hydration and texture and prevents dryness and irritation. It is stable and compatible with the skin, making it an effective choice for topical application.
- Ceramide AP: A shorter chain length compared to other ceramide types and is considered more effective in restoring and strengthening the skin's barrier.
- Ceramide EOP: The most abundant ceramide type in the skin's barrier. It helps to maintain the skin's hydration and prevent water loss.
- Ceramide Trio: Together, these ceramide types work synergistically to support the skin's barrier function and overall health.
- Phytosphingosine: Enhances the skin's barrier function. Its antimicrobial and anti-inflammatory properties make it particularly effective in treating acneic skin.
- Sodium Hyaluronate: The purest, salt form of hyaluronic acid, a master humectant that holds up to 1,000 times its weight in water to provide maximum hydration and plumping benefits to thirsty skin.
Water, Carthamus Tinctorius (Safflower) Oleosomes, Urea, Squalane, Caprylic/Capric Triglyceride, Glycerin, Sodium PCA, Sodium Acrylates Copolymer, Lecithin, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Sodium Hyaluronate Butyrate, Panthenol, Sodium Hyaluronate, Chondrus Crispus Extract, Propanediol, Dehydroacetic Acid, Benzyl Alcohol.







Explore More Recommendations
NeoGenesis Barrier Renewal Cream
- TCTracy C.Verified BuyerReviewingNeoGenesis Barrier Renewal CreamI recommend this productHow old are you? 40-49What is your skin type? DryWhat is your skin tone? MediumWhat are your skin concerns? Acne, Ageing, SensitivityRated 5 out of 5 stars13 hours agothe best
This is hands-down my favorite moisturizer. It’s the only one that never causes breakouts
Was this helpful? - ABAmy B.Verified BuyerReviewingNeoGenesis Barrier Renewal CreamI recommend this productHow old are you? 40-49What is your skin type? OilyWhat is your skin tone? MediumWhat are your skin concerns? Acne, Ageing, Blemish-prone, Oiliness, WrinklesRated 5 out of 5 stars2 months agoAmazing Moisturizer
I have oily, acne prone skin but this moisturizer perfectly balances moisture without the extra oily feeling and no breakouts!!
Was this helpful? - DDebbieVerified BuyerReviewingNeoGenesis Barrier Renewal CreamI recommend this productHow old are you? 50-65What is your skin type? CombinationWhat is your skin tone? FairRated 5 out of 5 stars2 months agoNew favorite
My skin has been a little dry this winter, decided to try a different moisturizer and this one is great. Goes on light and smooth but is very hydrating. Love it!
Was this helpful? - BMBecky May F.Verified BuyerReviewingNeoGenesis Barrier Renewal CreamHow old are you? 40-49What is your skin type? CombinationWhat is your skin tone? FairWhat are your skin concerns? Ageing, Blemish-prone, Redness, Oiliness, WrinklesRated 3 out of 5 stars2 months agoNice
I really enjoy the barrier-boosting ingredients in this formula! However, it's a little too thick for my liking here in South Florida. I mix a half a pea size in with my face reality gel moisturizer.
Was this helpful? - ABAlison B.Verified BuyerReviewingNeoGenesis Barrier Renewal CreamI recommend this productHow old are you? 40-49What is your skin type? CombinationWhat is your skin tone? MediumRated 5 out of 5 stars3 months agoSo great for dry+irritated winter skin
I love to use this over NeoGenesis recovery serum. It keeps my skin barrier happy and calm. I have very dry skin that can be red in the winter, so I usually add a heavier cream or oil over top to seal in moisture, but I think the cream might be enough on its own when the warmer weather rolls back around. A beauty pantry staple.
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At Art of Skin Care, we tailor solutions to you—no one-size-fits-all approach here. Whether tackling acne or embracing healthy aging, our expert estheticians will guide you every step of the way. More than a brand, we’re your partner in radiant, confident skin.