iS Clinical Brightening Complex
iS Clinical Brightening Complex takes a holistic, science-backed approach to enhancing skin brightness and overall health. This powerful daytime formula utilizes pharmaceutical-grade botanicals, stabilized vitamin C, and advanced DNA-repairing enzymes (Extremozymes) to visibly diminish dark spots, even out skin tone, and promote long-term skin resilience.
Designed to work synergistically with iS Clinical Brightening Serum, this duo creates a complete AM/PM regimen for tackling hyperpigmentation, rough texture, and dullness. Use the Brightening Complex in the morning to protect, hydrate, and prepare the skin, then follow with the Brightening Serum at night for gentle exfoliation and deeper pigment correction.
Tip: Many normal to oily skin types enjoy Brightening Complex as their daytime moisturizer, thanks to its lightweight, fast-absorbing texture and multi-action benefits.
- Brightens and evens skin tone
- Diminishes dark spots and hyperpigmentation
- Provides gentle exfoliation for a smoother texture
- Deeply hydrates and supports barrier health
- Defends against environmental damage with Extremozymes®
- Ideal AM partner to iS Clinical Brightening Serum
- pH 3.3 ± 0.5
1 oz | Airless Pump
Clinically Proven Results (in 72 hours):
- 37% reduction in melanin synthesis
We love this serum for all skin types, including sensitive ones, seeking brightening, hydration, and healthy-aging benefits in one powerful formula.
After cleansing and toning, apply a thin layer to face, neck, and chest, or areas affected by pigmentation, in morning and evening, layer with your favorite moisturizer. Be sure to follow with SPF when used in the AM.
- Willow Bark Extract: A natural form of salicylic acid that exfoliates and refines pores while calming inflammation.
- Sugar Cane Extract: Natural source of glycolic acid, provides more gentle exfoliation while also acting as a humectant to hydrate the skin.
- Glycerin: Provides long-lasting, intense moisture retention.
- Squalane: Keeps skin hydrated and balances oil production by mimicking the skin’s acid mantle while also reducing inflammation, soothing skin irritation, and improving elasticity.
- Hyaluronic Acid: Naturally occurring in the skin, provides intense hydration and plumps and improves skin barrier function by attracting and retaining moisture.
- Bilberry (Vaccinium Myrtillus) Extract: Antioxidant-rich ingredient that gently exfoliates, promotes healthy blood flow, and increases collagen production with calming effects for overall skin health.
- Norwegian Kelp (Ascophyllum Nodosum) Extract: Boosts exfoliation and acts as a tyrosinase inhibitor to improve hyperpigmentation and keep dark spots from forming.
- Vitamin C (BV-OSC/Tetrahexyldecyl Ascorbate): A stable, oil-soluble form of vitamin C that offers antioxidant and UV protection, skin lightening, DNA protection, and promotes collagen synthesis.
- Arbutin: Tyrosinase inhibitor that aids in brightening dark spots, preventing hyperpigmentation, and reducing scarring.
- Licorice Root Extract: Brightening and anti-inflammatory agent that balances skin tone and helps inhibit hyperpigmentation.
- Mushroom Extract: Rich in fatty acids, improves the ability of the skin to retain moisture and maintain a healthy skin barrier, while boosting collagen and calming inflammation.
Water/Aqua/Eau, Salix Alba (Willow) Bark Extract, Hyaluronic Acid, Saccharum Officinarum (Sugarcane) Extract [Extrait de canne à sucre], Vaccinium Myrtillus Fruit/Leaf Extract, Ascophyllum Nodosum Extract, Tetrahexyldecyl Ascorbate, Glycerin, Squalane, Imperata Cylindrica Root Extract, Glyceryl Stearate, Alpha-Arbutin, PEG-100 Stearate, PEG-8/SMDI Copolymer, Triethanolamine, Polyporus Umbellatus (Mushroom) Extract, Stearyl Alcohol, Cetearyl Alcohol, Glycyrrhiza Glabra (Licorice) Root Extract, Dimethicone, 1,2-Hexanediol, Caprylyl Glycol, Citrus Aurantium Dulcis (Orange) Oil, Xanthan Gum, Hydrogenated Lecithin, Disodium EDTA.
A multitasking morning treatment that brightens, hydrates, and protects, while setting the stage for your evening brightening routine.
- Unit price
- /per

Primary Concerns:
- Dullness
- Pigmentation
- Sun Damage
- Fine Lines

Best For:
- Combination
- Dry
- Normal
- Oily
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iS Clinical Brightening Complex
iS Clinical Brightening Complex takes a holistic, science-backed approach to enhancing skin brightness and overall health. This powerful daytime formula utilizes pharmaceutical-grade botanicals, stabilized vitamin C, and advanced DNA-repairing enzymes (Extremozymes) to visibly diminish dark spots, even out skin tone, and promote long-term skin resilience.
Designed to work synergistically with iS Clinical Brightening Serum, this duo creates a complete AM/PM regimen for tackling hyperpigmentation, rough texture, and dullness. Use the Brightening Complex in the morning to protect, hydrate, and prepare the skin, then follow with the Brightening Serum at night for gentle exfoliation and deeper pigment correction.
Tip: Many normal to oily skin types enjoy Brightening Complex as their daytime moisturizer, thanks to its lightweight, fast-absorbing texture and multi-action benefits.
- Brightens and evens skin tone
- Diminishes dark spots and hyperpigmentation
- Provides gentle exfoliation for a smoother texture
- Deeply hydrates and supports barrier health
- Defends against environmental damage with Extremozymes®
- Ideal AM partner to iS Clinical Brightening Serum
- pH 3.3 ± 0.5
1 oz | Airless Pump
Clinically Proven Results (in 72 hours):
- 37% reduction in melanin synthesis
We love this serum for all skin types, including sensitive ones, seeking brightening, hydration, and healthy-aging benefits in one powerful formula.
After cleansing and toning, apply a thin layer to face, neck, and chest, or areas affected by pigmentation, in morning and evening, layer with your favorite moisturizer. Be sure to follow with SPF when used in the AM.
- Willow Bark Extract: A natural form of salicylic acid that exfoliates and refines pores while calming inflammation.
- Sugar Cane Extract: Natural source of glycolic acid, provides more gentle exfoliation while also acting as a humectant to hydrate the skin.
- Glycerin: Provides long-lasting, intense moisture retention.
- Squalane: Keeps skin hydrated and balances oil production by mimicking the skin’s acid mantle while also reducing inflammation, soothing skin irritation, and improving elasticity.
- Hyaluronic Acid: Naturally occurring in the skin, provides intense hydration and plumps and improves skin barrier function by attracting and retaining moisture.
- Bilberry (Vaccinium Myrtillus) Extract: Antioxidant-rich ingredient that gently exfoliates, promotes healthy blood flow, and increases collagen production with calming effects for overall skin health.
- Norwegian Kelp (Ascophyllum Nodosum) Extract: Boosts exfoliation and acts as a tyrosinase inhibitor to improve hyperpigmentation and keep dark spots from forming.
- Vitamin C (BV-OSC/Tetrahexyldecyl Ascorbate): A stable, oil-soluble form of vitamin C that offers antioxidant and UV protection, skin lightening, DNA protection, and promotes collagen synthesis.
- Arbutin: Tyrosinase inhibitor that aids in brightening dark spots, preventing hyperpigmentation, and reducing scarring.
- Licorice Root Extract: Brightening and anti-inflammatory agent that balances skin tone and helps inhibit hyperpigmentation.
- Mushroom Extract: Rich in fatty acids, improves the ability of the skin to retain moisture and maintain a healthy skin barrier, while boosting collagen and calming inflammation.
Water/Aqua/Eau, Salix Alba (Willow) Bark Extract, Hyaluronic Acid, Saccharum Officinarum (Sugarcane) Extract [Extrait de canne à sucre], Vaccinium Myrtillus Fruit/Leaf Extract, Ascophyllum Nodosum Extract, Tetrahexyldecyl Ascorbate, Glycerin, Squalane, Imperata Cylindrica Root Extract, Glyceryl Stearate, Alpha-Arbutin, PEG-100 Stearate, PEG-8/SMDI Copolymer, Triethanolamine, Polyporus Umbellatus (Mushroom) Extract, Stearyl Alcohol, Cetearyl Alcohol, Glycyrrhiza Glabra (Licorice) Root Extract, Dimethicone, 1,2-Hexanediol, Caprylyl Glycol, Citrus Aurantium Dulcis (Orange) Oil, Xanthan Gum, Hydrogenated Lecithin, Disodium EDTA.







Explore More Recommendations
iS Clinical Brightening Complex
- ASAllison S.Verified BuyerReviewingiS Clinical Brightening ComplexI recommend this productHow old are you? 40-49Rated 5 out of 5 stars8 months agoiS Clinical Brightening Complex
Slight burning after applying. Have
Slight burning after applying. Have not had any other issues.
Was this helpful? - CScheryl s.Verified BuyerReviewingiS Clinical Brightening ComplexI recommend this productHow old are you? 30-39Rated 5 out of 5 stars9 months agoiS Clinical Brightening Complex
I am in love with
I am in love with this product for lightening my pigmentation. I have only been using this product for 2 weeks along with the iS brightening serum and I have already seen massive improvements in my melasma! It has a mild/pleasant smell and absorbs quickly into my skin. It is not greasy and does not pill with other products I am using in sunscreen.
Was this helpful? - MVMelissa V.Verified BuyerReviewingiS Clinical Brightening ComplexI recommend this productHow old are you? 50-65Rated 5 out of 5 stars11 months agoiS Clinical Brightening Complex
Keeper!
I have been experimenting with iS Clinical Products after having great success with their Active Peel. I have been using the Brightening Complex for about 4 weeks and am thrilled with the results. My skin looks brighter, healthier and wonderfully hydrated. Look forward to adding more iS Clinical products to my routine.
Was this helpful? - LCLindsay C.Verified BuyerReviewingiS Clinical Brightening ComplexI recommend this productHow old are you? 30-39Rated 5 out of 5 stars1 year agoiS Clinical Brightening Complex
So far I'm inpressed
I'm have only been in sing this for a couple weeks, but so far impressed. Definitely wake up with more glow. I have Melasma, so I'm not sure if it will help with that yet but I'm hopeful!
Was this helpful? - GRGretchen R.Verified BuyerReviewingiS Clinical Brightening ComplexI recommend this productHow old are you? 50-65Rated 5 out of 5 stars1 year agoiS Clinical Brightening Complex
Can't do without
This product is amazing and I have sensitive skin and it does not bother me. It definitely helps keep brown spots at bay in between my BBL's. Love all the Is clinical Products.
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Why Art of Skin Care?
At Art of Skin Care, we tailor solutions to you—no one-size-fits-all approach here. Whether tackling acne or embracing healthy aging, our expert estheticians will guide you every step of the way. More than a brand, we’re your partner in radiant, confident skin.