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What Should You Apply During Microneedling? The Updated Guide to Safe & Effective At-Home Needling

What Should You Apply During Microneedling? The Updated Guide to Safe & Effective At-Home Needling

Microneedling at home can be an amazing way to stimulate collagen, improve texture, and enhance product absorption—but what you put on your skin during and after the process matters more than ever. We’ve updated our microneedling protocol based on the latest research and real client feedback to help you get better results with less irritation—and without wasting your precious growth factor serums.

First Things First: Keep It Simple While You Needle

What should you apply during microneedling?

The goal is to keep your skin hydrated and comfortable—without introducing anything that could disrupt your skin barrier or degrade during needling. Our go-to is Le Mieux Iso Cell Recovery Solution.

  • Lightweight and soothing
  • Keeps the skin damp for smoother glide
  • Calms redness and irritation
  • Supports the skin’s healing response

Iso Cell Recovery Solution gives you exactly what you need during the process—hydration and slip—without clogging pores or causing sensitivity.

The Big Myth: "Needling in" Stem Cells or Growth Factors

This used to be common practice—but we now know better.Current research shows that microneedling over stem cells, peptides, and growth factors can damage their delivery systems , rendering them less effective or even inactive. These ingredients are delicate and designed to work after the skin has been micro-perforated—not during.

The New Protocol: What To Use After Microneedling

Once you’ve finished needling, your skin is perfectly primed to receive high-performance ingredients. That’s when you apply your growth factor serum. Our top picks:


These serums contain human-derived exosomes and growth factors that support recovery, reduce inflammation, and improve skin tone and texture—but only if applied at the right time.

In Summary:

  • Don’t microneedle over stem cell or growth factor serums
  • After Microneedling: Apply Plated Calm or Plated Intense Serum
  • During Microneedling: Use Le Mieux Iso Cell Recovery Solution
  • Follow with SPF the next morning

Want to elevate your at-home microneedling results? Stick to this updated protocol and let your products work smarter—not harder.


Need Help Choosing the Right Serum for Your Skin? Our expert estheticians are here to guide you every step of the way. Start your free consultation here.


Author

Jeana LeClerc

Jeana LeClerc is a licensed esthetician, Certified Acne Specialist, and the founder and CEO of Art of Skincare . With over 20 years of hands-on experience in the skincare industry, Jeana specializes in regenerative skincare —a powerful, holistic alternative to conventional anti-aging treatments.


Rejecting the pressure of injectables and invasive procedures, Jeana champions science-backed, skin-nourishing solutions that support healthy, youthful skin from the inside out. Her mission is to help clients achieve lasting skin transformation through personalized routines, professional-grade products, and a deep understanding of how the skin functions and regenerates.


At Art of Skincare, Jeana leads a team of expert estheticians dedicated to delivering results-driven skincare, from clearing acne to supporting healthy aging . Her blog and online consultations are trusted resources for those seeking radiant, resilient skin without compromise.