iS Clinical Active Serum 1oz cobalt blue glass dropper bottle with silver cap and white bulb, cosmeceuticals innovative skincare

iS Clinical Active Serum - Art of Skin Care

iS Clinical Active Serum dropper resting in petri dish with benefits: improves blemish-prone skin, paraben and hydroquinone-free, and improves pores and skin texture

iS Clinical Active Serum key ingredients on blue background: sugarcane extract gently exfoliates, bilberry extract natural exfoliant with moisturizing properties, and arbutin and mushroom extract minimize uneven skin tone and brighten complexion

Clinical before and after full-face photos showing reduced hyperpigmentation and more even skin tone after 30 days of iS Clinical Active Serum use

Clinical before and after close-up photos showing reduced fine lines and more even skin texture around the nose and cheek area after 90 days of iS Clinical Active Serum use

iS Clinical Active Serum shown with award from Instyle Best Beauty Buys 2021

iS Clinical Active Serum 0.5oz cobalt blue glass dropper bottle with silver cap and white bulb, cosmeceuticals innovative skincare

Acne Safe

iS Clinical Active Serum

Name: iS Clinical Active Serum
Brand: iS Clinical
SKU: IS001
Price: 96.0 USD
Availability: InStock

iS Clinical

A lightweight exfoliating serum with glycolic and salicylic acid that clears blemishes, fades dark spots, and smooths fine lines.

$96.00

Unit price: per

4.7

Rated 4.7 out of 5 stars

16 Reviews

Size: 0.5 oz

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iS Clinical Active Serum is a lightweight, multi-tasking botanical serum that addresses blemishes, fine lines, and uneven skin tone within a single clarifying formula. It carries a clean, subtle menthol scent and a cooling sensation on application, with a skin-compatible pH of 5.6 that works with your barrier rather than against it. The formula draws on botanical sources of both glycolic and salicylic acid, pairing them with brightening, collagen-supporting, and hydrating ingredients to deliver real results across multiple skin concerns at once.
Key Benefits
Dual-acid exfoliation that clears pores and smooths texture Sugarcane extract delivers glycolic acid and willow bark extract provides salicylic acid, working together to dissolve surface buildup, decongest pores, and refine rough skin without the irritation of synthetic acid concentrations.
Reduces blemishes and keeps skin clear Salicylic acid from willow bark penetrates into pores to dissolve oil and debris, making this an effective daily option for acne-prone skin that still wants a gentle touch.
Softens fine lines and supports collagen Mushroom extract (polyporus umbellatus) and bilberry (vaccinium myrtillus) encourage collagen synthesis and cell renewal, visibly reducing the appearance of fine lines with continued use.
Fades discoloration and evens tone Arbutin works to inhibit melanin production and fade post-inflammatory hyperpigmentation, helping skin look more uniform and consistent in tone over time.
Supports moisture retention and barrier resilience Glycerin and mushroom extract work together to reinforce the skin's moisture barrier, keeping skin hydrated, firm, and balanced even as the exfoliating actives do their work.
Clinically Proven Results (3 months/using twice daily in combination with Cleansing Complex):
94% improvement in active acne
83% improvement in acne scars
82% improvement in appearance of pore size
73% improvement in skin texture
64% improvement in fine lines and wrinkles
56% improvement in pigment irregularities
If your skin is dealing with breakouts and fine lines at the same time, iS Clinical Active Serum is built for exactly that. It's ideal for combination, oily, or acne-prone skin types who want the clarifying power of salicylic and glycolic acid alongside real anti-aging support, without having to layer multiple treatment products.
It's also a strong fit for anyone working through uneven skin tone, enlarged pores, rough texture, or post-acne discoloration. The botanical delivery of both exfoliating acids makes it more tolerable than many traditional acid treatments, though those with sensitive skin may want to ease in slowly and monitor their response to the menthol cooling sensation.
If you're looking to simplify your routine without trading down on results, this serum covers a lot of ground in one step.
The menthol in this serum creates a noticeable tingling sensation that tells you it's working, but if you find it too intense at first, try warming one to two drops between your palms before pressing them gently onto skin rather than spreading the serum directly. This slows the delivery slightly and makes the initial adjustment period more comfortable.
Prepare: Cleanse and tone skin, then allow it to dry completely before applying.
Apply: Dispense 3 to 5 drops and spread evenly over face, neck, and chest.
Frequency: Begin with once daily use and increase to twice daily as your skin adjusts. Always follow morning use with a broad-spectrum SPF, as exfoliating acids increase sensitivity to UV exposure.
Key Ingredients

Sugar Cane Extract: Natural source of glycolic acid, provides more gentle exfoliation while also acting as a humectant to hydrate the skin.
Bilberry (Vaccinium Myrtillus) Extract: Antioxidant-rich ingredient that gently exfoliates, promotes healthy blood flow, and increases collagen production with calming effects for overall skin health.
Willow Bark Extract: A natural form of salicylic acid that exfoliates and refines pores while calming inflammation.
Mushroom Extract: Rich in fatty acids, improves the ability of the skin to retain moisture and maintain a healthy skin barrier, while boosting collagen and calming inflammation.

Water/Aqua/Eau, Glycerin, Butylene Glycol, Alcohol Denat., Saccharum Officinarum (Sugarcane) Extract [Extrait de canne à sucre], Vaccinium Myrtillus Fruit/Leaf Extract, Triethanolamine, Salix Alba (Willow) Bark Extract, Glyceryl Polyacrylate, Arbutin, Polyporus Umbellatus (Mushroom) Extract, Menthol, Phenoxyethanol.
Can I use iS Clinical Active Serum if I have sensitive skin?

iS Clinical Active Serum contains botanical sources of both glycolic and salicylic acid, plus menthol, which can be stimulating for sensitive skin types. Start with every other evening application and observe how your skin responds before increasing frequency. If tingling becomes uncomfortable rather than mild and passing, reduce use and give your barrier time to adjust.

What does iS Clinical Active Serum smell like?

The serum has a clean, subtle menthol scent that reads as fresh and slightly medicinal rather than perfumed or floral. The menthol also creates a cooling, tingling sensation on the skin upon application, which fades within a few minutes.

How long does it take to see results with iS Clinical Active Serum?

Most users notice smoother texture and a more even tone within one to two weeks of consistent use. Improvements in blemishes, fine lines, and post-inflammatory hyperpigmentation tend to become more visible after four to six weeks, as cell turnover accelerates and arbutin works to fade discoloration over time.

Can I use iS Clinical Active Serum alongside a retinol?

Yes, but layer with intention to avoid over-exfoliation. A practical approach is to use iS Clinical Active Serum in the morning and retinol at night, or to alternate the two on different evenings. Watch for dryness, flaking, or irritation and dial back frequency if either appears.

Does iS Clinical Active Serum help with acne scars or hyperpigmentation?

Yes. The combination of glycolic acid from sugarcane extract, salicylic acid from willow bark, and arbutin creates a multi-pronged approach to fading post-inflammatory hyperpigmentation. Glycolic and salicylic acids accelerate cell turnover to bring fresh skin to the surface, while arbutin works to inhibit melanin production at the source. Consistent use over several weeks produces meaningful improvement in tone and the residual marks left by breakouts.

Should I use iS Clinical Active Serum in the morning or at night?

Both are appropriate. Morning use allows you to take advantage of the clarifying and brightening benefits throughout the day, though it is essential to follow with a broad-spectrum SPF since the exfoliating acids in the formula increase UV sensitivity. Evening use is a solid choice for those easing into the formula or pairing it with other treatments.

What is the difference between the 0.5 oz and 1 oz sizes of iS Clinical Active Serum?

The formula is identical across both sizes. The 0.5 oz is a practical option for travel or for testing the serum before committing to the full size. The 1 oz bottle offers better value for daily, long-term use and is the better choice once you know the formula works well for your skin.

Why buy iS Clinical Active Serum from Art of Skin Care?

Art of Skin Care is an authorized retailer of iS Clinical, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if iS Clinical Active Serum is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.

Learn More

iS Clinical Active Serum is a lightweight, multi-tasking botanical serum that addresses blemishes, fine lines, and uneven skin tone within a single clarifying formula. It carries a clean, subtle menthol scent and a cooling sensation on application, with a skin-compatible pH of 5.6 that works with your barrier rather than against it. The formula draws on botanical sources of both glycolic and salicylic acid, pairing them with brightening, collagen-supporting, and hydrating ingredients to deliver real results across multiple skin concerns at once.

Key Benefits

Dual-acid exfoliation that clears pores and smooths texture Sugarcane extract delivers glycolic acid and willow bark extract provides salicylic acid, working together to dissolve surface buildup, decongest pores, and refine rough skin without the irritation of synthetic acid concentrations.

Reduces blemishes and keeps skin clear Salicylic acid from willow bark penetrates into pores to dissolve oil and debris, making this an effective daily option for acne-prone skin that still wants a gentle touch.

Softens fine lines and supports collagen Mushroom extract (polyporus umbellatus) and bilberry (vaccinium myrtillus) encourage collagen synthesis and cell renewal, visibly reducing the appearance of fine lines with continued use.

Fades discoloration and evens tone Arbutin works to inhibit melanin production and fade post-inflammatory hyperpigmentation, helping skin look more uniform and consistent in tone over time.

Supports moisture retention and barrier resilience Glycerin and mushroom extract work together to reinforce the skin's moisture barrier, keeping skin hydrated, firm, and balanced even as the exfoliating actives do their work.

Clinical Results

Who it's For

Esthetician Recommendations

How to Use

Ingredients

Frequently Asked Questions

Can I use iS Clinical Active Serum if I have sensitive skin?

iS Clinical Active Serum contains botanical sources of both glycolic and salicylic acid, plus menthol, which can be stimulating for sensitive skin types. Start with every other evening application and observe how your skin responds before increasing frequency. If tingling becomes uncomfortable rather than mild and passing, reduce use and give your barrier time to adjust.

What does iS Clinical Active Serum smell like?

The serum has a clean, subtle menthol scent that reads as fresh and slightly medicinal rather than perfumed or floral. The menthol also creates a cooling, tingling sensation on the skin upon application, which fades within a few minutes.

How long does it take to see results with iS Clinical Active Serum?

Most users notice smoother texture and a more even tone within one to two weeks of consistent use. Improvements in blemishes, fine lines, and post-inflammatory hyperpigmentation tend to become more visible after four to six weeks, as cell turnover accelerates and arbutin works to fade discoloration over time.

Can I use iS Clinical Active Serum alongside a retinol?

Yes, but layer with intention to avoid over-exfoliation. A practical approach is to use iS Clinical Active Serum in the morning and retinol at night, or to alternate the two on different evenings. Watch for dryness, flaking, or irritation and dial back frequency if either appears.

Does iS Clinical Active Serum help with acne scars or hyperpigmentation?

Yes. The combination of glycolic acid from sugarcane extract, salicylic acid from willow bark, and arbutin creates a multi-pronged approach to fading post-inflammatory hyperpigmentation. Glycolic and salicylic acids accelerate cell turnover to bring fresh skin to the surface, while arbutin works to inhibit melanin production at the source. Consistent use over several weeks produces meaningful improvement in tone and the residual marks left by breakouts.

Should I use iS Clinical Active Serum in the morning or at night?

Both are appropriate. Morning use allows you to take advantage of the clarifying and brightening benefits throughout the day, though it is essential to follow with a broad-spectrum SPF since the exfoliating acids in the formula increase UV sensitivity. Evening use is a solid choice for those easing into the formula or pairing it with other treatments.

What is the difference between the 0.5 oz and 1 oz sizes of iS Clinical Active Serum?

The formula is identical across both sizes. The 0.5 oz is a practical option for travel or for testing the serum before committing to the full size. The 1 oz bottle offers better value for daily, long-term use and is the better choice once you know the formula works well for your skin.

Why buy iS Clinical Active Serum from Art of Skin Care?

Art of Skin Care is an authorized retailer of iS Clinical, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if iS Clinical Active Serum is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.