Dr. esthé Rejuvenating Cream
This unique cream provides nourishment and healing to dry or damaged skin in need of hydration, repair, and barrier support. The star ingredient is the PDRN, from salmon DNA, which is highly effective for speeding up cell regeneration and repairing damaged tissue. Maca root boosts the skin’s recovery ability while improving overall texture. We especially love this as an overnight treatment to renew and replenish the skin.
- Rich and nourishing
- Repairs and hydrates
- Speeds up cell turnover
- Provides skin barrier support
2.4 oz (70ml) | Tube
We recommend this for dry, sensitive, barrier-damaged skin will appreciate the reparative qualities of this cream.
This cream is lovely layered over retinol to help mitigate any dryness or irritation.
After cleansing and toning, apply to face, neck, and chest morning and evening. In the AM, be sure to follow up with your favorite SPF. Recommended to pair with Dr. esthe Rejuvenating Toner and Dr. esthé Rejuvenating Ampoule.
- PDRN (Salmon DNA): Promotes collagen biosynthesis and enhancement of skin cell activity to promote tissue regeneration and wound healing.
- Centella Asiatica Extract: Helps to strengthen and repair the skin's moisture barrier with potent anti-inflammatory benefits and antioxidant protection.
- Beta-Glucan: Soothes, moisturizes, and protects while helping stimulate collagen synthesis.
- Sodium Hyaluronate: The purest, salt form of hyaluronic acid, a master humectant that holds up to 1,000 times its weight in water to provide maximum hydration and plumping benefits to thirsty skin.
- Ceramide NP: Improves the skin's hydration and texture and prevents dryness and irritation. It is stable and compatible with the skin, making it an effective choice for topical application.
Water, Glycerin, Cetearyl Alcohol, Dipropylene Glycol, Hydrogenated Polydecene, Caprylic/Capric Triglyceride, Hydrogenated Poly (C6-14 Olefin), Beta-Glucan, Cyclohexasiloxane, Dimethiconol, 1,2Hexanediol, Niacinamide, Dicaprylyl Ether, Vegetable Oil, Glyceryl Stearate SE, Centella Asiatica Extract, Ficus Carica (Fig) Fruit Extract, Lepidium Meyenii Root Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Behenyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Polyacrylate-13, Microcrystalline Cellulose, Cetearyl Glucoside, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydrogenated Polyisobutene, Betaine, Butylene Glycol, Cholesterol, Cellulose Gum, Polyglyceryl-10 Laurate, Hydrolyzed Corn Starch, Sorbitan Isostearate, Adenosine, Ethylhexyl Palmitate, Disodium EDTA, Ceramide NP, Sucrose, Sodium DNA, Glucose, Maltodextrin, Polysorbate 60, Fragrance, Ethylhexylglycerin, Linalool
Dr. esthé Rejuvenating Cream is a rich, occlusive cream infused with PDRN that provides healing, cell regeneration, and soothing support to sensitive or damaged skin.
- Unit price
- /per

Primary Concerns:
- Dryness
- Compromised Barrier

Best For:
- Dry
- Sensitive
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Dr. esthé Rejuvenating Cream
This unique cream provides nourishment and healing to dry or damaged skin in need of hydration, repair, and barrier support. The star ingredient is the PDRN, from salmon DNA, which is highly effective for speeding up cell regeneration and repairing damaged tissue. Maca root boosts the skin’s recovery ability while improving overall texture. We especially love this as an overnight treatment to renew and replenish the skin.
- Rich and nourishing
- Repairs and hydrates
- Speeds up cell turnover
- Provides skin barrier support
2.4 oz (70ml) | Tube
We recommend this for dry, sensitive, barrier-damaged skin will appreciate the reparative qualities of this cream.
This cream is lovely layered over retinol to help mitigate any dryness or irritation.
After cleansing and toning, apply to face, neck, and chest morning and evening. In the AM, be sure to follow up with your favorite SPF. Recommended to pair with Dr. esthe Rejuvenating Toner and Dr. esthé Rejuvenating Ampoule.
- PDRN (Salmon DNA): Promotes collagen biosynthesis and enhancement of skin cell activity to promote tissue regeneration and wound healing.
- Centella Asiatica Extract: Helps to strengthen and repair the skin's moisture barrier with potent anti-inflammatory benefits and antioxidant protection.
- Beta-Glucan: Soothes, moisturizes, and protects while helping stimulate collagen synthesis.
- Sodium Hyaluronate: The purest, salt form of hyaluronic acid, a master humectant that holds up to 1,000 times its weight in water to provide maximum hydration and plumping benefits to thirsty skin.
- Ceramide NP: Improves the skin's hydration and texture and prevents dryness and irritation. It is stable and compatible with the skin, making it an effective choice for topical application.
Water, Glycerin, Cetearyl Alcohol, Dipropylene Glycol, Hydrogenated Polydecene, Caprylic/Capric Triglyceride, Hydrogenated Poly (C6-14 Olefin), Beta-Glucan, Cyclohexasiloxane, Dimethiconol, 1,2Hexanediol, Niacinamide, Dicaprylyl Ether, Vegetable Oil, Glyceryl Stearate SE, Centella Asiatica Extract, Ficus Carica (Fig) Fruit Extract, Lepidium Meyenii Root Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Behenyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Polyacrylate-13, Microcrystalline Cellulose, Cetearyl Glucoside, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydrogenated Polyisobutene, Betaine, Butylene Glycol, Cholesterol, Cellulose Gum, Polyglyceryl-10 Laurate, Hydrolyzed Corn Starch, Sorbitan Isostearate, Adenosine, Ethylhexyl Palmitate, Disodium EDTA, Ceramide NP, Sucrose, Sodium DNA, Glucose, Maltodextrin, Polysorbate 60, Fragrance, Ethylhexylglycerin, Linalool




Explore More Recommendations
Dr. esthé Rejuvenating Cream
- CKcindy k.Verified BuyerReviewingDr. esthé Rejuvenating CreamI recommend this productHow old are you? Over 65What is your skin type? CombinationWhat is your skin tone? FairWhat are your skin concerns? Redness, AgeingRated 5 out of 5 stars3 weeks agoLove my skin cream!
I love this rejuvenating cream! It's an absolute value! You only need a small amount, it lasts a long time! My skin feels smoother and I get so many complements on it!
Thank you!!
Was this helpful? - AFAdina F.Verified BuyerReviewingDr. esthé Rejuvenating CreamI recommend this productHow old are you? 50-65What is your skin type? CombinationWhat is your skin tone? FairWhat are your skin concerns? Ageing, Dryness, WrinklesRated 5 out of 5 stars1 month agoVery nice
Wouldnt have bought this without suggestion but I really like it. Feels very nourishing and worls well under makeup. Hard to tell long term benefits right now but will see!
Was this helpful? - TTressaVerified BuyerReviewingDr. esthé Rejuvenating CreamI recommend this productHow old are you? 18-29What is your skin type? DryWhat is your skin tone? MediumWhat are your skin concerns? Sensitivity, Dryness, AgeingRated 5 out of 5 stars3 months agoPlease do not ever stop carrying this cream!
I have tried everything from luxury to drugstore skin care products trying to find the perfect match for my skin. I received my order yesterday of Dr.Esthe’s Rejuvenating line along with the Dr.Esthe cleaning gel and Ezyme cleanser. My skin lately has been red, irritated, dry, flaking and I felt like every morning I was waking up to inflamed dry skin. Don’t forget the fine lines I didn’t know I had from my skin being so parched. I have never used Dr.Esthe products, but decided to completely replace my old routine. My skin immediately felt relief yesterday when I first tried these products. This morning I woke up with glowing skin that was moist to the touch. I HAVE NEVER HAD THAT HAPPEN EVER! The lines are gone, the flaking is gone, my skin is soothed, it’s no longer dry, the redness is almost completely gone, the lines from my skin being so parched are gone and I look like I have a new face. This cream is to die for by the way! It absorbed into my skin while still leaving a protective barrier. I was outside in the cold and wind this morning then when I went back inside to look in the mirror my skin was still hydrated and glowing. Never does that happen! It also smells like a fresh bouquet of flowers. Not a fake or strong perfume smell, just beautiful light fresh 🌸
Was this helpful? - SBSharon B.Verified BuyerReviewingDr. esthé Rejuvenating CreamI recommend this productHow old are you? Over 65Rated 5 out of 5 stars1 year agoDr. esth Rejuvenating Cream
So far so great
I have been using it for about 3 weeks and now seeing a difference in the lines and hydration in my neck.
Was this helpful? - HCHSUANLING C.Verified BuyerReviewingDr. esthé Rejuvenating CreamI recommend this productHow old are you? 50-65Rated 5 out of 5 stars1 year agoDr. esth Rejuvenating Cream
Dr. esthe Rejuvenating Cream
This cream is so nourishing and hydrated. I highly recommend and will repurchase it.
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Why Art of Skin Care?
At Art of Skin Care, we tailor solutions to you—no one-size-fits-all approach here. Whether tackling acne or embracing healthy aging, our expert estheticians will guide you every step of the way. More than a brand, we’re your partner in radiant, confident skin.