Epicutis Lipid Serum in a frosted glass bottle with dropper resting open at an angle on a light gray background

Epicutis Lipid Serum in a frosted glass dropper bottle on a light gray background

Before and after comparison of a woman's face using Epicutis product.

Before and after comparison of a person's face using Epicutis product showing greatly reduced redness

Before and after comparison of a woman's face using Epicutis Simple System, showing visible skin improvement.

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Epicutis Lipid Serum

Name: Epicutis Lipid Serum
Brand: Epicutis
SKU: EP004
Price: 250.0 USD
Availability: InStock

Epicutis

A lightweight, fragrance-free barrier repair serum that calms redness, deeply hydrates, and protects against collagen loss for sensitive skin.

$250.00

Unit price: per

4.8

Rated 4.8 out of 5 stars

17 Reviews

Size: 1 oz

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Epicutis Lipid Serum is a barrier repair serum built around a patented bioactive lipid called TSC (disodium tetramethylhexadecenyl succinoyl cysteine), a molecule that mimics the skin's own barrier-building blocks to calm inflammation, defend against collagen loss, and restore long-term resilience. With only eight total ingredients, this minimalist formula delivers immediate relief to dry, inflamed, or post-procedure skin while strengthening the barrier over time so skin can better protect itself. The formula is completely fragrance-free, making it appropriate even for the most reactive skin.
Key Benefits
Calms Inflammation and Visible Redness TSC works at the cellular level to quiet inflammatory pathways, reducing redness and reactivity from rosacea, sensitized skin, or post-procedure recovery.
Restores and Reinforces the Skin Barrier Propanediol, pentylene glycol, and glycerin work alongside TSC to replenish the lipid matrix your barrier depends on, helping skin hold onto moisture and resist environmental triggers.
Protects Against Collagen Breakdown TSC shields collagen from degradation caused by UV exposure and pollution, providing anti-aging defense without the irritation of traditional actives like retinoids or acids.
Delivers Lightweight, Lasting Hydration Sodium hyaluronate draws and binds water into the skin, while glycerin and pentylene glycol lock it in, keeping skin comfortable and hydrated without any heaviness or residue.
Minimalist, Sensitivity-Safe Formula Just eight ingredients total, no fragrance, no dyes, no unnecessary additives. This intentional simplicity makes it one of the safest serums available for reactive, compromised, or post-treatment skin.
Epicutis Lipid Serum is ideal for anyone dealing with barrier damage, chronic dryness, redness, or sensitivity. If your skin feels tight, reacts to nearly everything you apply, or struggles to hold onto moisture, this serum restores the foundation your skin needs to function and heal properly.
It is also a trusted option for post-procedure recovery. Whether you have had a chemical peel, laser treatment, or a significant sun exposure event, this formula provides the immediate comfort and sustained repair your skin needs to recover without setbacks.
If you are managing early signs of aging alongside sensitivity, this serum offers both collagen protection and barrier support without the irritation that commonly accompanies traditional anti-aging actives like retinol or glycolic acid.
Store this serum in the refrigerator and press it onto skin immediately after a peel, sun exposure, or a sensitivity flare for an instant cooling reset that visibly calms inflammation and supports faster recovery.
Prepare: Apply to clean, dry skin morning and night.
Apply: Dispense 1 to 2 drops into the palms and gently press into the face, neck, and décolleté.
Frequency: Use twice daily, followed by your preferred moisturizer.
Key Ingredients

TSC (Disodium Tetramethylhexadecenyl Succinoyl Cysteine): A breakthrough super-lipid that strengthens the skin’s natural barrier while providing powerful protection against environmental stressors like UV rays and pollution.
Sodium Hyaluronate: The purest, salt form of hyaluronic acid, a master humectant that holds up to 1,000 times its weight in water to provide maximum hydration and plumping benefits to thirsty skin.
Propanediol: Moisturizes skin, improves texture, and assists with product absorption. Also contains antimicrobial properties.
Glycerin: Provides long-lasting, intense moisture retention.

Water, Propanediol, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Sodium Phytate, Citric Acid
What is TSC and how does it work in Epicutis Lipid Serum?

TSC (disodium tetramethylhexadecenyl succinoyl cysteine) is a patented bioactive lipid that mimics the skin's natural barrier-building blocks. It works by calming inflammation at the cellular level, protecting against environmental stressors like UV exposure and pollution, and helping to prevent collagen breakdown. TSC is the cornerstone of Epicutis's clinical approach to barrier repair and long-term skin resilience.

Can I use Epicutis Lipid Serum immediately after a chemical peel or laser treatment?

Yes. Epicutis Lipid Serum is specifically formulated with post-procedure skin in mind and is safe to use as soon as your provider gives you clearance to apply topicals. Its gentle, anti-inflammatory formula delivers soothing relief and barrier support during recovery without any risk of additional irritation.

How long does one bottle of Epicutis Lipid Serum last?

When used as directed with 1 to 2 drops twice daily, one bottle typically lasts about three months. This is a highly concentrated formula, so a small amount is sufficient to cover the face, neck, and décolleté each application.

Is Epicutis Lipid Serum suitable for oily or acne-prone skin?

Yes. While the formula is lipid-based, it is lightweight and fast-absorbing, meaning it will not feel heavy or clog pores. It is particularly beneficial for acne-prone skin that has been compromised by harsh treatments or over-exfoliation, as it helps restore barrier function without adding excess oil or triggering breakouts.

Can I layer Epicutis Lipid Serum with active ingredients like retinol or vitamin C?

Yes. Epicutis Lipid Serum is designed to be layered and actually helps improve your skin's tolerance to actives by keeping the barrier strong and calm. Apply it first after cleansing, allow it to absorb, then follow with your treatment serums and moisturizer. It works especially well as a buffer for sensitive skin using retinoids or exfoliating acids.

Does Epicutis Lipid Serum contain fragrance or potential irritants?

No. Epicutis Lipid Serum is completely fragrance-free and formulated with only eight ingredients total. This intentional minimalism makes it one of the safest options available for reactive, sensitized, or post-treatment skin that cannot tolerate unnecessary additives.

Will Epicutis Lipid Serum help with redness from rosacea?

Yes. The anti-inflammatory properties of TSC make Epicutis Lipid Serum particularly effective for calming the chronic redness and reactivity associated with rosacea. Used consistently, it works to strengthen the skin barrier and reduce the frequency and intensity of flare-ups while providing visible relief during active episodes.

Why buy Epicutis Lipid Serum from Art of Skin Care?

Art of Skin Care is an authorized retailer of Epicutis, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if Epicutis Lipid Serum is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.

Learn More

Epicutis Lipid Serum is a barrier repair serum built around a patented bioactive lipid called TSC (disodium tetramethylhexadecenyl succinoyl cysteine), a molecule that mimics the skin's own barrier-building blocks to calm inflammation, defend against collagen loss, and restore long-term resilience. With only eight total ingredients, this minimalist formula delivers immediate relief to dry, inflamed, or post-procedure skin while strengthening the barrier over time so skin can better protect itself. The formula is completely fragrance-free, making it appropriate even for the most reactive skin.

Key Benefits

Calms Inflammation and Visible Redness TSC works at the cellular level to quiet inflammatory pathways, reducing redness and reactivity from rosacea, sensitized skin, or post-procedure recovery.

Restores and Reinforces the Skin Barrier Propanediol, pentylene glycol, and glycerin work alongside TSC to replenish the lipid matrix your barrier depends on, helping skin hold onto moisture and resist environmental triggers.

Protects Against Collagen Breakdown TSC shields collagen from degradation caused by UV exposure and pollution, providing anti-aging defense without the irritation of traditional actives like retinoids or acids.

Delivers Lightweight, Lasting Hydration Sodium hyaluronate draws and binds water into the skin, while glycerin and pentylene glycol lock it in, keeping skin comfortable and hydrated without any heaviness or residue.

Minimalist, Sensitivity-Safe Formula Just eight ingredients total, no fragrance, no dyes, no unnecessary additives. This intentional simplicity makes it one of the safest serums available for reactive, compromised, or post-treatment skin.

Who it's For

Esthetician Recommendations

How to Use

Ingredients

Frequently Asked Questions

What is TSC and how does it work in Epicutis Lipid Serum?

TSC (disodium tetramethylhexadecenyl succinoyl cysteine) is a patented bioactive lipid that mimics the skin's natural barrier-building blocks. It works by calming inflammation at the cellular level, protecting against environmental stressors like UV exposure and pollution, and helping to prevent collagen breakdown. TSC is the cornerstone of Epicutis's clinical approach to barrier repair and long-term skin resilience.

Can I use Epicutis Lipid Serum immediately after a chemical peel or laser treatment?

Yes. Epicutis Lipid Serum is specifically formulated with post-procedure skin in mind and is safe to use as soon as your provider gives you clearance to apply topicals. Its gentle, anti-inflammatory formula delivers soothing relief and barrier support during recovery without any risk of additional irritation.

How long does one bottle of Epicutis Lipid Serum last?

When used as directed with 1 to 2 drops twice daily, one bottle typically lasts about three months. This is a highly concentrated formula, so a small amount is sufficient to cover the face, neck, and décolleté each application.

Is Epicutis Lipid Serum suitable for oily or acne-prone skin?

Yes. While the formula is lipid-based, it is lightweight and fast-absorbing, meaning it will not feel heavy or clog pores. It is particularly beneficial for acne-prone skin that has been compromised by harsh treatments or over-exfoliation, as it helps restore barrier function without adding excess oil or triggering breakouts.

Can I layer Epicutis Lipid Serum with active ingredients like retinol or vitamin C?

Yes. Epicutis Lipid Serum is designed to be layered and actually helps improve your skin's tolerance to actives by keeping the barrier strong and calm. Apply it first after cleansing, allow it to absorb, then follow with your treatment serums and moisturizer. It works especially well as a buffer for sensitive skin using retinoids or exfoliating acids.

Does Epicutis Lipid Serum contain fragrance or potential irritants?

No. Epicutis Lipid Serum is completely fragrance-free and formulated with only eight ingredients total. This intentional minimalism makes it one of the safest options available for reactive, sensitized, or post-treatment skin that cannot tolerate unnecessary additives.

Will Epicutis Lipid Serum help with redness from rosacea?

Yes. The anti-inflammatory properties of TSC make Epicutis Lipid Serum particularly effective for calming the chronic redness and reactivity associated with rosacea. Used consistently, it works to strengthen the skin barrier and reduce the frequency and intensity of flare-ups while providing visible relief during active episodes.

Why buy Epicutis Lipid Serum from Art of Skin Care?

Art of Skin Care is an authorized retailer of Epicutis, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if Epicutis Lipid Serum is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.