Circadia Serum 71

Circadia Serum 71 is a multitasking treatment serum that targets hyperpigmentation, adult acne, uneven texture, and early loss of firmness in a single evening step. Built around a trio of clinically recognized brightening acids, 2% tranexamic acid, 5% mandelic acid, and 0.3% azelaic acid, it addresses the full spectrum of pigment and breakout concerns while remaining gentle enough for sensitive skin. This serum is fragrance-free.

Key Benefits

Fades Dark Spots and Melasma Transexamic acid works at 2% to interrupt the signaling pathways that trigger excess melanin production, making it one of the most effective non-hydroquinone options for melasma and stubborn post-acne marks.

Gently Exfoliates and Clears Pores Mandelic acid at 5% delivers controlled exfoliation with a larger molecular size than most acids, meaning it penetrates more slowly and is less likely to cause irritation while still refining texture and keeping pores clear.

Controls Redness and Breakouts Azelaic acid at 0.3% supports the formula's acne-fighting action by calming inflammation and reducing the presence of acne-causing bacteria, making it particularly useful for adult acne and rosacea-prone skin.

Firms and Supports Collagen Production Neodermyl, a next-generation copper peptide complex present as copper lysinate/prolinate and methylglucoside phosphate, is clinically recognized to stimulate collagen and elastin synthesis, improving skin density and elasticity over time.

Calms Inflammation and Strengthens the Barrier Magnesium carboxymethyl beta-glucan, the active form of CM-Glucan Forte, helps neutralize inflammation and reinforce the skin barrier, making this formula well-suited for reactive and sensitive skin types.

Circadia Serum 71 is suitable for all skin types, including sensitive, oily, combination, and mature skin. Its non-inflammatory formula is designed to deliver real brightening and firming results without the irritation, peeling, or redness that often comes with traditional acid treatments or peels.

This serum is especially well-matched for anyone dealing with melasma, post-inflammatory hyperpigmentation, adult acne, or early skin laxity. Because it addresses multiple concerns in one formula, it is a practical choice for those who want to simplify their routine without sacrificing results.

It also works well as a maintenance step between professional chemical peels or enzyme treatments, helping to extend and protect the results you get in the treatment room.

Start with three evenings per week during your first two weeks to allow your skin to acclimate, then gradually build toward nightly use. Because tranexamic acid, mandelic acid, and azelaic acid are all working together overnight, consistency matters more than frequency at the start. Patience in the adjustment period is what leads to the clearest, most even results long term.

Prepare: Cleanse and lightly mist skin.

Apply: Dispense 3 to 5 drops into your fingertips.

Technique: Press gently into the face, neck, and chest.

Follow: Layer a moisturizer over the serum to seal in hydration.

Frequency: Begin with 3 times per week for the first two weeks, then increase to nightly as tolerated. Always apply SPF the following morning.

We offer free shipping on every order $50+ (just $7 flat-rate below that). Orders placed before 1pm PST Monday through Friday ship out the same day. Orders placed outside of that window are shipped the very next day!

Changed your mind? We get it. That's why our return window is generous: 30 days even if you've opened and tried it, or a full 60 days if it's still sealed. Some exclusions apply. See our full return policy for details.