Emepelle Estrogen Deficient Skin Set
For skin that suddenly feels drier, thinner or less firm during perimenopause and menopause.
This complete AM + PM system targets the visible effects of declining estrogen with Emepelle's non-hormonal MEP Technology®.
- Unit price
- /per
Adding product to your cart
-
The Emepelle Estrogen Deficient Skin Set by Emepelle is a complete skincare system built specifically for the skin changes that come with declining estrogen during perimenopause and menopause. At the heart of this set is MEP Technology®, a non-hormonal active ingredient (methyl estradiolpropanoate) that works at the cellular level to address the root cause of estrogen-deficient skin, not just the surface symptoms. The full-size Emepelle Serum and Emepelle Cream work together across your AM and PM routines, with a bonus deluxe Emepelle Eye Cream sample targeting the delicate eye area where changes often show up first.
Key Benefits
Non-Hormonal Estrogen Support MEP Technology® (methyl estradiolpropanoate) mimics the effect of estrogen in skin cells without entering the bloodstream, helping to restore the cellular signaling that keeps skin firm and resilient.
Visible Reduction in Fine Lines The Emepelle Cream combines retinol and hydroxypinacolone retinoate, a gentler retinoid ester, with palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 to support collagen production and visibly smooth the look of fine lines over time.
Strengthened Antioxidant Defense The Emepelle Serum delivers a multi-antioxidant complex of 3-O-ethyl ascorbic acid (a stable vitamin C derivative), ferulic acid, glutathione, and superoxide dismutase to neutralize free radicals and help protect skin from oxidative stress that accelerates aging.
Deep, Lasting Hydration Sodium hyaluronate and hydrolyzed hyaluronic acid across both formulas draw moisture into the skin and help retain it, while shea butter, grape seed oil, and glycerin in the Emepelle Cream reinforce the skin barrier for sustained comfort.
Brighter, More Even Tone Niacinamide in both the serum and cream works to visibly reduce discoloration and uneven tone, a concern that often intensifies with hormonal changes, while tetrapeptide-26 supports skin renewal.
-
Clinically proven to help address accelerated collagen loss and skin aging due to estrogen-deficient skin; in a study using Emepelle Serum and Emepelle Night Cream for 8 weeks:
- 100% of study participants showed improvement in skin hydration
- 93% of study participants agreed that Emepelle improved the appearance of their skin
- 64% of study participants saw a reduction in wrinkles
Clinically-Proven Benefits of MEP Technology® after application for 14 weeks:
- 54% improvement in dryness
- 39% improvement in dullness
- 19% improvement in laxity
-
This set is ideal for women in perimenopause or menopause who have noticed their skin becoming drier, thinner, looser, or duller in ways that standard anti-aging products haven't fully addressed. If you're dealing with accelerated fine lines, a loss of firmness, increased sensitivity, or skin that feels chronically dehydrated despite your routine, hormonal skin changes are likely a contributing factor.
It is also well suited for those who want targeted, science-backed support for estrogen-deficient skin without hormone therapy. Because the serum and cream work across both morning and evening routines, this set delivers consistent daily and nightly support in one coordinated system.
If you are new to retinol, this set eases you in gradually with a built-in acclimation schedule, making it accessible even if you haven't used vitamin A products before. Those with very sensitive skin, eczema, or rosacea should consult a skincare professional before beginning.
-
If you are new to retinol or have been finding your skin more reactive than it used to be, start the Emepelle Cream on your slowest nights, such as two to three times per week, and let your skin set the pace before moving to nightly use. The MEP Technology® works cumulatively, so consistency over weeks matters far more than pushing frequency too fast.
-
Prepare: Cleanse skin thoroughly and pat dry before applying either product.
Morning Routine: Apply the Emepelle Serum to clean, dry skin in the AM. Follow with your preferred SPF, as daily sun protection is essential when using this system.
Evening Routine: Apply the Emepelle Cream at night. For the first two weeks, use every other night to allow your skin to acclimate to the retinol. After two weeks, progress to nightly use as tolerated.
Eye Area: Apply the Emepelle Eye Cream sample to the orbital bone area, avoiding direct contact with the eyes.
Frequency: Mild dryness, redness, or flaking may occur during the initial adjustment period. Slow your frequency if needed and increase gradually. Avoid using additional exfoliants, AHAs, BHAs, or ascorbic acid products alongside the Emepelle Cream unless directed by a skincare professional. Use sunscreen daily and limit direct sun exposure while using this set.
-
Key Ingredients
- MEP Technology®: Patented ingredient to restore the function of estrogen in the skin without the use of hormones. Improves hydration, texture, and boosts collagen production.
- Vitamin C (L-Ascorbic Acid): A powerful antioxidant with anti-inflammatory properties, which helps reduce skin redness, brighten complexion, and even skin tone.
- Peptides: Short chains of amino acids that signal the skin to produce more collagen and elastin. Think of them as messengers that tell your skin to repair and firm itself.
- Retinol: A derivative of vitamin A that provides exfoliation and stimulates collagen production, reducing the appearance of fine lines and wrinkles.
- Hyaluronic Acid: Naturally occurring in the skin, provides intense hydration and plumps and improves skin barrier function by attracting and retaining moisture.
Emepelle Serum: Water (Aqua), Dimethyl Isosorbide, Niacinamide, Butylene Glycol, 3-O-Ethyl Ascorbic Acid, Glycereth-26, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Methyl Estradiolpropanoate, Superoxide Dismutase, Glyceryl Caprate, Ferulic Acid, Glutathione, Pentapeptide-28, Tetrapeptide-26, Camellia Sinensis Leaf Extract, Sodium Hyaluronate, Dipeptide-4, Glycerin, 1,2-Hexanediol, Caprylyl Glycol, Tocopheryl Acetate, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Disodium EDTA
Emepelle Cream: Water (Aqua), Niacinamide, Dimethyl Isosorbide, Butylene Glycol, Caprylic/Capric Triglyceride, Butyrospermum Parkii (Shea) Butter, Glycerin, Methyl Estradiolpropanoate, Cetearyl Alcohol, Octyldodecyl Myristate, Tridecyl Stearate, Tridecyl Trimellitate, Vitis Vinifera (Grape) Seed Oil, Glyceryl Stearate, PEG-100 Stearate, Ceteareth-20, Phenoxyethanol, Retinol, Butyrospermum Parkii (Shea) Butter Extract, Caprylyl Glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Apricot Kernel Oil PEG-6 Esters, Sodium Hyaluronate, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Tetrapeptide-26, Polysorbate 20, Hydroxypinacolone Retinoate, Ethylhexylglycerin, Hydrolyzed Hyaluronic Acid, Dipentaerythrityl Hexacaprylate/Hexacaprate, Polymethyl Methacrylate, Carbomer, Disodium EDTA, BHT, Potassium Hydroxide -
What is MEP Technology® and how does it work in the Emepelle Estrogen Deficient Skin Set?
MEP Technology® refers to methyl estradiolpropanoate, the active ingredient that makes Emepelle unique in the skincare market. It is a non-hormonal molecule that works at the skin cell receptor level to restore signaling pathways that decline when estrogen drops, without entering the bloodstream or acting as a hormone in the body. This means it addresses the root cellular cause of estrogen-deficient skin changes rather than just treating surface symptoms. Both the serum and the cream in the Emepelle Estrogen Deficient Skin Set are formulated with MEP Technology® to deliver this benefit across your full daily routine.
Is the Emepelle Estrogen Deficient Skin Set safe to use without hormone therapy?
Yes. The Emepelle Estrogen Deficient Skin Set is designed specifically as a non-hormonal alternative or complement to hormone therapy. MEP Technology® does not contain hormones and does not function as a systemic hormone, making it distinct from topical estrogen treatments. It is formulated to support skin that has been affected by declining estrogen levels through a topical, skincare-based approach.
What retinoids are in the Emepelle Cream and how strong are they?
The Emepelle Cream contains two forms of vitamin A: retinol and hydroxypinacolone retinoate. Retinol is a well-researched, over-the-counter retinoid that converts to retinoic acid in the skin to stimulate cell turnover and collagen support. Hydroxypinacolone retinoate is a retinoid ester that delivers similar benefits with a gentler tolerance profile, making the Emepelle Cream effective while being more accessible to those who have previously found retinol irritating. Starting with every-other-night use for the first two weeks allows your skin to build tolerance before progressing to nightly application.
Can I use the Emepelle Estrogen Deficient Skin Set if I already have a vitamin C product in my routine?
The Emepelle Serum already contains 3-O-ethyl ascorbic acid, a stable vitamin C derivative, alongside ferulic acid, which enhances its antioxidant activity. Because of this, adding an additional vitamin C product in the same routine is generally unnecessary and could increase the risk of irritation, particularly if using the Emepelle Cream with retinol at night. We recommend avoiding additional ascorbic acid products while using this set unless a skincare professional advises otherwise. If you have questions about how to integrate this into your existing routine, reach out for a free skincare consultation.
How long does it take to see results from the Emepelle Estrogen Deficient Skin Set?
Most users begin to notice changes in skin texture, hydration, and tone within four to six weeks of consistent use, with more visible improvements in firmness and fine lines typically appearing after eight to twelve weeks. Because MEP Technology® works by restoring cellular behavior over time, results build progressively with continued use. Consistency with both the serum in the morning and the cream at night is key to seeing the full benefit of the system.
What skin concerns does the Emepelle Estrogen Deficient Skin Set specifically address?
This set is formulated for the cluster of changes that are common with estrogen-deficient skin: increased dryness and loss of plumpness, reduced firmness and elasticity, accelerated development of fine lines, uneven skin tone, and a general dullness that does not resolve with standard moisturizers. Niacinamide in both formulas targets visible discoloration, the peptide complex in the cream supports collagen, and the antioxidant blend in the serum helps protect against further environmental damage. The system addresses these concerns as a whole rather than isolating a single symptom.
What is included in the Emepelle Estrogen Deficient Skin Set?
The set includes the full-size Emepelle Serum, the full-size Emepelle Cream, and a deluxe sample of the Emepelle Eye Cream. The serum is intended for morning use and delivers antioxidant and MEP Technology® benefits, the cream is formulated for evening use and adds retinol, peptides, and deep moisturizing ingredients, and the eye cream sample brings MEP Technology® to the delicate skin around the eyes. Purchasing the set saves 20% compared to buying the serum and moisturizer individually.
Why buy the Emepelle Estrogen Deficient Skin Set from Art of Skin Care?
Art of Skin Care is an authorized retailer of Emepelle, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if the Emepelle Estrogen Deficient Skin Set is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
The Emepelle Estrogen Deficient Skin Set by Emepelle is a complete skincare system built specifically for the skin changes that come with declining estrogen during perimenopause and menopause. At the heart of this set is MEP Technology®, a non-hormonal active ingredient (methyl estradiolpropanoate) that works at the cellular level to address the root cause of estrogen-deficient skin, not just the surface symptoms. The full-size Emepelle Serum and Emepelle Cream work together across your AM and PM routines, with a bonus deluxe Emepelle Eye Cream sample targeting the delicate eye area where changes often show up first.
Key Benefits
Non-Hormonal Estrogen Support MEP Technology® (methyl estradiolpropanoate) mimics the effect of estrogen in skin cells without entering the bloodstream, helping to restore the cellular signaling that keeps skin firm and resilient.
Visible Reduction in Fine Lines The Emepelle Cream combines retinol and hydroxypinacolone retinoate, a gentler retinoid ester, with palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 to support collagen production and visibly smooth the look of fine lines over time.
Strengthened Antioxidant Defense The Emepelle Serum delivers a multi-antioxidant complex of 3-O-ethyl ascorbic acid (a stable vitamin C derivative), ferulic acid, glutathione, and superoxide dismutase to neutralize free radicals and help protect skin from oxidative stress that accelerates aging.
Deep, Lasting Hydration Sodium hyaluronate and hydrolyzed hyaluronic acid across both formulas draw moisture into the skin and help retain it, while shea butter, grape seed oil, and glycerin in the Emepelle Cream reinforce the skin barrier for sustained comfort.
Brighter, More Even Tone Niacinamide in both the serum and cream works to visibly reduce discoloration and uneven tone, a concern that often intensifies with hormonal changes, while tetrapeptide-26 supports skin renewal.
Clinically proven to help address accelerated collagen loss and skin aging due to estrogen-deficient skin; in a study using Emepelle Serum and Emepelle Night Cream for 8 weeks:
- 100% of study participants showed improvement in skin hydration
- 93% of study participants agreed that Emepelle improved the appearance of their skin
- 64% of study participants saw a reduction in wrinkles
Clinically-Proven Benefits of MEP Technology® after application for 14 weeks:
- 54% improvement in dryness
- 39% improvement in dullness
- 19% improvement in laxity
This set is ideal for women in perimenopause or menopause who have noticed their skin becoming drier, thinner, looser, or duller in ways that standard anti-aging products haven't fully addressed. If you're dealing with accelerated fine lines, a loss of firmness, increased sensitivity, or skin that feels chronically dehydrated despite your routine, hormonal skin changes are likely a contributing factor.
It is also well suited for those who want targeted, science-backed support for estrogen-deficient skin without hormone therapy. Because the serum and cream work across both morning and evening routines, this set delivers consistent daily and nightly support in one coordinated system.
If you are new to retinol, this set eases you in gradually with a built-in acclimation schedule, making it accessible even if you haven't used vitamin A products before. Those with very sensitive skin, eczema, or rosacea should consult a skincare professional before beginning.
If you are new to retinol or have been finding your skin more reactive than it used to be, start the Emepelle Cream on your slowest nights, such as two to three times per week, and let your skin set the pace before moving to nightly use. The MEP Technology® works cumulatively, so consistency over weeks matters far more than pushing frequency too fast.
Prepare: Cleanse skin thoroughly and pat dry before applying either product.
Morning Routine: Apply the Emepelle Serum to clean, dry skin in the AM. Follow with your preferred SPF, as daily sun protection is essential when using this system.
Evening Routine: Apply the Emepelle Cream at night. For the first two weeks, use every other night to allow your skin to acclimate to the retinol. After two weeks, progress to nightly use as tolerated.
Eye Area: Apply the Emepelle Eye Cream sample to the orbital bone area, avoiding direct contact with the eyes.
Frequency: Mild dryness, redness, or flaking may occur during the initial adjustment period. Slow your frequency if needed and increase gradually. Avoid using additional exfoliants, AHAs, BHAs, or ascorbic acid products alongside the Emepelle Cream unless directed by a skincare professional. Use sunscreen daily and limit direct sun exposure while using this set.
- MEP Technology®: Patented ingredient to restore the function of estrogen in the skin without the use of hormones. Improves hydration, texture, and boosts collagen production.
- Vitamin C (L-Ascorbic Acid): A powerful antioxidant with anti-inflammatory properties, which helps reduce skin redness, brighten complexion, and even skin tone.
- Peptides: Short chains of amino acids that signal the skin to produce more collagen and elastin. Think of them as messengers that tell your skin to repair and firm itself.
- Retinol: A derivative of vitamin A that provides exfoliation and stimulates collagen production, reducing the appearance of fine lines and wrinkles.
- Hyaluronic Acid: Naturally occurring in the skin, provides intense hydration and plumps and improves skin barrier function by attracting and retaining moisture.
Emepelle Serum: Water (Aqua), Dimethyl Isosorbide, Niacinamide, Butylene Glycol, 3-O-Ethyl Ascorbic Acid, Glycereth-26, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Methyl Estradiolpropanoate, Superoxide Dismutase, Glyceryl Caprate, Ferulic Acid, Glutathione, Pentapeptide-28, Tetrapeptide-26, Camellia Sinensis Leaf Extract, Sodium Hyaluronate, Dipeptide-4, Glycerin, 1,2-Hexanediol, Caprylyl Glycol, Tocopheryl Acetate, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Disodium EDTA
Emepelle Cream: Water (Aqua), Niacinamide, Dimethyl Isosorbide, Butylene Glycol, Caprylic/Capric Triglyceride, Butyrospermum Parkii (Shea) Butter, Glycerin, Methyl Estradiolpropanoate, Cetearyl Alcohol, Octyldodecyl Myristate, Tridecyl Stearate, Tridecyl Trimellitate, Vitis Vinifera (Grape) Seed Oil, Glyceryl Stearate, PEG-100 Stearate, Ceteareth-20, Phenoxyethanol, Retinol, Butyrospermum Parkii (Shea) Butter Extract, Caprylyl Glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Apricot Kernel Oil PEG-6 Esters, Sodium Hyaluronate, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Tetrapeptide-26, Polysorbate 20, Hydroxypinacolone Retinoate, Ethylhexylglycerin, Hydrolyzed Hyaluronic Acid, Dipentaerythrityl Hexacaprylate/Hexacaprate, Polymethyl Methacrylate, Carbomer, Disodium EDTA, BHT, Potassium Hydroxide
What is MEP Technology® and how does it work in the Emepelle Estrogen Deficient Skin Set?
MEP Technology® refers to methyl estradiolpropanoate, the active ingredient that makes Emepelle unique in the skincare market. It is a non-hormonal molecule that works at the skin cell receptor level to restore signaling pathways that decline when estrogen drops, without entering the bloodstream or acting as a hormone in the body. This means it addresses the root cellular cause of estrogen-deficient skin changes rather than just treating surface symptoms. Both the serum and the cream in the Emepelle Estrogen Deficient Skin Set are formulated with MEP Technology® to deliver this benefit across your full daily routine.
Is the Emepelle Estrogen Deficient Skin Set safe to use without hormone therapy?
Yes. The Emepelle Estrogen Deficient Skin Set is designed specifically as a non-hormonal alternative or complement to hormone therapy. MEP Technology® does not contain hormones and does not function as a systemic hormone, making it distinct from topical estrogen treatments. It is formulated to support skin that has been affected by declining estrogen levels through a topical, skincare-based approach.
What retinoids are in the Emepelle Cream and how strong are they?
The Emepelle Cream contains two forms of vitamin A: retinol and hydroxypinacolone retinoate. Retinol is a well-researched, over-the-counter retinoid that converts to retinoic acid in the skin to stimulate cell turnover and collagen support. Hydroxypinacolone retinoate is a retinoid ester that delivers similar benefits with a gentler tolerance profile, making the Emepelle Cream effective while being more accessible to those who have previously found retinol irritating. Starting with every-other-night use for the first two weeks allows your skin to build tolerance before progressing to nightly application.
Can I use the Emepelle Estrogen Deficient Skin Set if I already have a vitamin C product in my routine?
The Emepelle Serum already contains 3-O-ethyl ascorbic acid, a stable vitamin C derivative, alongside ferulic acid, which enhances its antioxidant activity. Because of this, adding an additional vitamin C product in the same routine is generally unnecessary and could increase the risk of irritation, particularly if using the Emepelle Cream with retinol at night. We recommend avoiding additional ascorbic acid products while using this set unless a skincare professional advises otherwise. If you have questions about how to integrate this into your existing routine, reach out for a free skincare consultation.
How long does it take to see results from the Emepelle Estrogen Deficient Skin Set?
Most users begin to notice changes in skin texture, hydration, and tone within four to six weeks of consistent use, with more visible improvements in firmness and fine lines typically appearing after eight to twelve weeks. Because MEP Technology® works by restoring cellular behavior over time, results build progressively with continued use. Consistency with both the serum in the morning and the cream at night is key to seeing the full benefit of the system.
What skin concerns does the Emepelle Estrogen Deficient Skin Set specifically address?
This set is formulated for the cluster of changes that are common with estrogen-deficient skin: increased dryness and loss of plumpness, reduced firmness and elasticity, accelerated development of fine lines, uneven skin tone, and a general dullness that does not resolve with standard moisturizers. Niacinamide in both formulas targets visible discoloration, the peptide complex in the cream supports collagen, and the antioxidant blend in the serum helps protect against further environmental damage. The system addresses these concerns as a whole rather than isolating a single symptom.
What is included in the Emepelle Estrogen Deficient Skin Set?
The set includes the full-size Emepelle Serum, the full-size Emepelle Cream, and a deluxe sample of the Emepelle Eye Cream. The serum is intended for morning use and delivers antioxidant and MEP Technology® benefits, the cream is formulated for evening use and adds retinol, peptides, and deep moisturizing ingredients, and the eye cream sample brings MEP Technology® to the delicate skin around the eyes. Purchasing the set saves 20% compared to buying the serum and moisturizer individually.
Why buy the Emepelle Estrogen Deficient Skin Set from Art of Skin Care?
Art of Skin Care is an authorized retailer of Emepelle, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if the Emepelle Estrogen Deficient Skin Set is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
You May Also Like
Emepelle Estrogen Deficient Skin Set
- Effectiveness
- Hydration
- Texture
- Ingredients
- Value
- GGAVerified BuyerReviewingEmepelle SerumHow old are you? 50-65What is your skin type? DryWhat is your skin tone? MediumWhat are your skin concerns? Redness, Sun Damage, Ageing, Pigmentation, WrinklesRated 3 out of 5 stars2 days agoNice and smooth
This serum goes on nice and smooth but it seems to need a lot of moisturizer on top and I am not sure I am seeing results. A lot of money for imperceptible results. I do sometimes feel tingly after applying it which seems to mean it is working.
Was this helpful? - PSPam S.Verified BuyerReviewingEmepelle SerumI recommend this productHow old are you? Over 65What is your skin type? DryWhat is your skin tone? MediumWhat are your skin concerns? Ageing, Wrinkles, Sun DamageRated 5 out of 5 stars4 days agoWas hesitant…
I have been hesitant to purchase this serum mainly because of the price. However - it’s the best serum I’ve ever used (and I’ve tried numerous brands and formulas). The bottle is large so it’s like getting two bottles in one. Totally worth it!
Was this helpful? - JRJami R.Verified BuyerReviewingEmepelle Estrogen Deficient Skin SetI recommend this productHow old are you? 40-49What is your skin type? DryWhat is your skin tone? FairWhat are your skin concerns? Acne, Ageing, Pigmentation, DrynessRated 5 out of 5 stars1 month agoHas made all the difference
These two products along with the eye cream have made all the difference in the skin. I’m going to perimenopause and immediately I could tell back to its normal self and not dry even after I put on several moisturizers like it was. I’m very happy with this product and plans to use it for a long time.
Was this helpful? - DJDeborah J.Verified BuyerReviewingEmepelle Estrogen Deficient Skin SetI recommend this productHow old are you? Over 65What is your skin type? DryWhat is your skin tone? MediumWhat are your skin concerns? Wrinkles, Ageing, Dryness, OtherRated 4 out of 5 stars1 month agoLove this duo
At 70 I am definitely estrogen deficient. The serum is lovely sinks in quickly. Works well with my daytime skincare. The nighttime cream has retinol which no matter how many brands or ways of applying I could not use retinol. I apply this over mystro and am working up to nightly. I really am impressed with the concept.
Was this helpful? - CCChristine C.Verified BuyerReviewingEmepelle SerumI recommend this productHow old are you? 50-65What is your skin type? DryWhat is your skin tone? MediumWhat are your skin concerns? AgeingRated 5 out of 5 stars1 month agoAwesome product for Aging Skin
Awesome product for Aging Skin
Was this helpful?