The Emepelle Estrogen Deficient Skin Set by Emepelle is a complete skincare system built specifically for the skin changes that come with declining estrogen during perimenopause and menopause. At the heart of this set is MEP Technology®, a non-hormonal active ingredient (methyl estradiolpropanoate) that works at the cellular level to address the root cause of estrogen-deficient skin, not just the surface symptoms. The full-size Emepelle Serum and Emepelle Cream work together across your AM and PM routines, with a bonus deluxe Emepelle Eye Cream sample targeting the delicate eye area where changes often show up first.

Key Benefits

Non-Hormonal Estrogen Support MEP Technology® (methyl estradiolpropanoate) mimics the effect of estrogen in skin cells without entering the bloodstream, helping to restore the cellular signaling that keeps skin firm and resilient.

Visible Reduction in Fine Lines The Emepelle Cream combines retinol and hydroxypinacolone retinoate, a gentler retinoid ester, with palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 to support collagen production and visibly smooth the look of fine lines over time.

Strengthened Antioxidant Defense The Emepelle Serum delivers a multi-antioxidant complex of 3-O-ethyl ascorbic acid (a stable vitamin C derivative), ferulic acid, glutathione, and superoxide dismutase to neutralize free radicals and help protect skin from oxidative stress that accelerates aging.

Deep, Lasting Hydration Sodium hyaluronate and hydrolyzed hyaluronic acid across both formulas draw moisture into the skin and help retain it, while shea butter, grape seed oil, and glycerin in the Emepelle Cream reinforce the skin barrier for sustained comfort.

Brighter, More Even Tone Niacinamide in both the serum and cream works to visibly reduce discoloration and uneven tone, a concern that often intensifies with hormonal changes, while tetrapeptide-26 supports skin renewal.

Clinically proven to help address accelerated collagen loss and skin aging due to estrogen-deficient skin; in a study using Emepelle Serum and Emepelle Night Cream for 8 weeks:

• 100% of study participants showed improvement in skin hydration
• 93% of study participants agreed that Emepelle improved the appearance of their skin
• 64% of study participants saw a reduction in wrinkles

Clinically-Proven Benefits of MEP Technology® after application for 14 weeks:

• 54% improvement in dryness
• 39% improvement in dullness
• 19% improvement in laxity

This set is ideal for women in perimenopause or menopause who have noticed their skin becoming drier, thinner, looser, or duller in ways that standard anti-aging products haven't fully addressed. If you're dealing with accelerated fine lines, a loss of firmness, increased sensitivity, or skin that feels chronically dehydrated despite your routine, hormonal skin changes are likely a contributing factor.

It is also well suited for those who want targeted, science-backed support for estrogen-deficient skin without hormone therapy. Because the serum and cream work across both morning and evening routines, this set delivers consistent daily and nightly support in one coordinated system.

If you are new to retinol, this set eases you in gradually with a built-in acclimation schedule, making it accessible even if you haven't used vitamin A products before. Those with very sensitive skin, eczema, or rosacea should consult a skincare professional before beginning.

If you are new to retinol or have been finding your skin more reactive than it used to be, start the Emepelle Cream on your slowest nights, such as two to three times per week, and let your skin set the pace before moving to nightly use. The MEP Technology® works cumulatively, so consistency over weeks matters far more than pushing frequency too fast.

Prepare: Cleanse skin thoroughly and pat dry before applying either product.

Morning Routine: Apply the Emepelle Serum to clean, dry skin in the AM. Follow with your preferred SPF, as daily sun protection is essential when using this system.

Evening Routine: Apply the Emepelle Cream at night. For the first two weeks, use every other night to allow your skin to acclimate to the retinol. After two weeks, progress to nightly use as tolerated.

Eye Area: Apply the Emepelle Eye Cream sample to the orbital bone area, avoiding direct contact with the eyes.

Frequency: Mild dryness, redness, or flaking may occur during the initial adjustment period. Slow your frequency if needed and increase gradually. Avoid using additional exfoliants, AHAs, BHAs, or ascorbic acid products alongside the Emepelle Cream unless directed by a skincare professional. Use sunscreen daily and limit direct sun exposure while using this set.