Senté Bio Complete Serum is the retinoid serum for everyone who has been told their skin is too sensitive for retinol. This evening treatment combines slow-release retinoids with Senté's patented Heparan Sulfate Analog (HSA) to boost cell turnover, stimulate collagen and elastin production, and deliver clinically proven even skin tone within 8 weeks — without the redness, peeling, or adjustment period that comes with traditional vitamin A. If retinol has ever let you down before, this is where you start over.

Key Benefits

Retinol Results Without the Irritation
Slow-release retinoids deliver vitamin A gradually over time, so your skin gets the full cell-renewing and collagen-stimulating benefit without the dryness and peeling that typically come with it.

HSA Actively Fights Inflammation While Retinol Works
Senté's patented HSA boosts the skin's immune response to inflammation, keeping skin calm and hydrated while the retinoids drive renewal underneath. It is the reason this formula works where others have failed.

Clinically Shown to Even Skin Tone in 8 Weeks
The HSA and retinoid combination is clinically shown to deliver more even-looking skin tone within 8 weeks, with continued improvement in fine lines and skin vitality over time.

Stimulates Collagen and Elastin for Firmer Skin
Retinol and retinyl safflowerate work together to accelerate cell turnover and signal your skin to rebuild collagen and elastin, visibly reducing fine lines and improving firmness with consistent use.

Brightens and Protects with Stabilized Vitamin C
Sodium Ascorbyl Phosphate, a stable and skin-friendly form of vitamin C, fades discoloration, evens tone, and defends against environmental damage, all while remaining well-tolerated by sensitive and rosacea-prone skin.

Formulated to Pair with Dermal Repair Cream
Bio Complete Serum is designed to be layered under Senté Dermal Repair Cream each evening, which seals in the actives, supports your barrier overnight, and makes the whole system noticeably more effective.

If you have been wanting to add a retinoid to your routine but have held back because of sensitivity, dryness, or past bad experiences with retinol — Bio Complete Serum is made for you. The slow-release retinoid format and the presence of HSA make it one of the most tolerable vitamin A serums available, and it is a favorite recommendation for first-time retinol users across all skin types.

It is equally well suited for sensitive and rosacea-prone skin that needs meaningful skin renewal without triggering flares. Because HSA reduces the skin's inflammatory response while the retinoids work, the formula is able to deliver clinical-grade results in skin that simply cannot handle traditional retinol.

For clients who are already using Senté Dermal Repair Cream and want to take their results further, Bio Complete Serum is the natural and most effective next step. It is not recommended for use during pregnancy or breastfeeding, and those new to retinol should build use gradually over the first two weeks before moving to nightly application.

Introduce Sente Bio Complete Serum slowly if you are new to retinol. Start by applying it two to three evenings per week for the first two weeks before moving to nightly use, always following with Sente Dermal Repair Cream to minimize any transitional dryness. Never use this serum in the morning, and always apply a broad-spectrum SPF the following day.

Prepare: Apply to clean, dry skin in the evening only. Cleanse and tone before applying the serum. If you are new to retinol, start with 2 to 3 nights per week and gradually increase to nightly use as tolerated.

Apply: Dispense 3 to 5 drops and gently press across the face, neck, and décolleté, avoiding the immediate eye area unless directed otherwise.

Technique: Allow 1 to 2 minutes to absorb before applying Sente Dermal Repair Cream over the top to seal in the active ingredients and support barrier function through the night.

Frequency: Use every evening once fully acclimated. Always apply a broad-spectrum SPF of 30 or higher the following morning, as retinol increases photosensitivity. Do not use in the morning.