FACTORFIVE Regenerative Serum
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FACTORFIVE Regenerative Serum is a multi-targeted anti-aging serum built around the highest concentration of human stem cell conditioned media in the entire FACTORFIVE lineup. Rather than addressing just one sign of aging, this lightweight gel serum works across five visible concerns at once: wrinkles, sun spots, skin laxity, thinning skin, and uneven texture. It applies smoothly, dries down quickly, and layers beautifully under makeup or moisturizer, with a fresh melon scent that fades shortly after application.
Key Benefits:
Targets Five Visible Signs of Aging at Once: Human stem cell conditioned media, the first ingredient on the list, delivers a concentrated blend of growth factors that help reduce the look of wrinkles, dark spots, laxity, thinning, and rough texture in a single step.
Smooths and Tightens Skin Texture: Bis(tripeptide-1) copper acetate, a copper peptide complex, visibly firms skin and helps refine the appearance of pores and uneven surface texture over time.
Brightens and Evens Skin Tone: Sodium ascorbyl phosphate, a stable form of vitamin C, works alongside niacinamide to reduce the look of hyperpigmentation, redness, and dull, uneven tone.
Calms and Hydrates Without Heaviness: Aloe vera, green tea extract, and sodium hyaluronate deliver lightweight hydration and soothing comfort, making the serum suitable even for reactive or sensitive skin.
Clean, Professional-Grade Formula: Free of parabens, mineral oil, sulfates, phthalates, urea, DEA, and TEA. Clinically tested, allergy tested, hypoallergenic, and dermatologist tested.
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If you are looking for a single serum that addresses multiple signs of aging, from fine lines and dark spots to loss of firmness and rough texture, this is designed for you. It is especially well suited if your skin shows sun damage, enlarged pores, or uneven tone and you want visible brightening and tightening without layering multiple products.
Suitable for all skin types, including sensitive and reactive skin. The lightweight gel texture absorbs quickly and works well under makeup, making it practical for both morning and evening routines.
Ideal for anyone who wants a growth factor serum with clinical-level ingredients but prefers a clean formulation free of common irritants.
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Because this serum dries down so cleanly, it makes an excellent first layer in your morning routine. Apply it to bare skin, give it about 60 seconds to set, then follow with moisturizer and sunscreen. You will notice it creates a smooth, slightly tightened canvas that helps makeup sit more evenly throughout the day.
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Prepare: Shake the bottle well before each use. Start with clean, dry skin.
Apply: Dispense one pump of serum and smooth it over your face and neck using gentle upward strokes.
Frequency: Use morning and night for best results. Follow with your preferred moisturizer and sunscreen during the day.
Storage: Keep in a cool, dry place away from direct sunlight to preserve the growth factor activity.
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Key Ingredients
- Human Adipose Mesenchymal Stem Cell Conditioned Media: Collected output of adult adipose-derived stem cells, rich in growth factors, anti-inflammatory molecules, and signaling proteins that communicate directly with the skin's own repair mechanisms to support tissue regeneration and restore structural integrity at a cellular level.
- Copper Tripeptide-1 (GHK-Cu): Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- SNAP-8 (Acetyl Octapeptide-3): A neuropeptide that relaxes wrinkles caused in expression zones such as the forehead and eye area. Reduces wrinkle depth, smoothes, and promotes an even texture.
- Acmella Oleracea Extract: Often called the "natural Botox" ingredient, it is prized for its ability to help smooth the look of fine lines by supporting a relaxed, more even skin surface.
- Vitamin C (Sodium Ascorbyl Phosphate): Stabilized water-soluble, less acidic form of vitamin C suitable for sensitive skin and rosacea. Possesses antimicrobial properties that help diminish breakouts and inflammation.
- Camellia Sinensis Leaf Extract: A powerful antioxidant that helps defend against environmental stress, calm inflammation, and support a stronger, more resilient skin barrier.
Human Stem Cell Conditioned Media, Water (Aqua), Aloe Barbadensis Leaf Juice, Glycerin, Niacinamide, PEG8/SDMI Copolymer, Sodium Ascorbyl Phosphate, Phenoxyethanol, Hydroxyethylcellulose, Xanthan Gum, Acetyl Octapeptide-3, Acmella Oleracea Extract, Bis (Tripeptide-1) Copper Acetate, Camellia Sinensis (Green Tea) Leaf Extract, Lecithin, Polysorbate 20, Sodium Hyaluronate, Ethylhexylglycerin, Fragrance, Citric Acid, Disodium EDTA, Palmitoyl Tripeptide-37
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We offer free shipping on every order $50+ (just $7 flat-rate below that). Orders placed before 1pm PST Monday through Friday ship out the same day. Orders placed outside of that window are shipped the very next business day!
Changed your mind? We get it. That's why our return window is generous: 30 days even if you've opened and tried it, or a full 60 days if it's still sealed. Some exclusions apply. See our full return policy for details. -
What makes FACTORFIVE Regenerative Serum different from other anti-aging serums?
It contains the highest concentration of human stem cell conditioned media in the FACTORFIVE lineup, listed as the very first ingredient. This growth factor-rich base is paired with copper peptides, niacinamide, and a stable vitamin C to address five visible signs of aging in one serum: wrinkles, sun spots, laxity, thinning, and uneven texture.
What are the growth factors in FACTORFIVE Regenerative Serum?
The growth factors come from human stem cell conditioned media, which is the nutrient-rich liquid collected after culturing human stem cells. This media contains a complex of naturally occurring growth factors, cytokines, and proteins that help support the skin's visible renewal processes. It is the first and most concentrated ingredient in this serum.
Will FACTORFIVE Regenerative Serum work under makeup?
Yes, and this is actually one of its standout qualities. The lightweight gel texture absorbs and dries down quickly, creating a smooth, slightly firmed surface. Many users find it improves how makeup applies and wears throughout the day.
Can FACTORFIVE Regenerative Serum help with hyperpigmentation and redness?
It is specifically formulated to address uneven tone. Sodium ascorbyl phosphate, a stable vitamin C, provides a brightening effect, while niacinamide helps reduce the appearance of dark spots and visible redness over consistent use.
Is FACTORFIVE Regenerative Serum safe for sensitive skin?
Yes. The formula is clinically tested, allergy tested, hypoallergenic, and dermatologist tested. It is also free of parabens, mineral oil, sulfates, phthalates, urea, DEA, and TEA. Aloe vera and green tea extract provide additional soothing and calming support.
How long does one bottle of FACTORFIVE Regenerative Serum last?
The 1 oz bottle delivers approximately 130 to 150 pumps. When used as directed at one pump twice daily, a single bottle typically lasts 1.5 to 2 months.
What does FACTORFIVE Regenerative Serum smell like?
It has a fresh melon fragrance that is noticeable upon application but fades quickly. The scent is light and does not linger or interfere with other products in your routine.
Why buy FACTORFIVE Regenerative Serum from Art of Skin Care?
Art of Skin Care is an authorized retailer of FACTORFIVE, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if FACTORFIVE Regenerative Serum is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
FACTORFIVE Regenerative Serum is a multi-targeted anti-aging serum built around the highest concentration of human stem cell conditioned media in the entire FACTORFIVE lineup. Rather than addressing just one sign of aging, this lightweight gel serum works across five visible concerns at once: wrinkles, sun spots, skin laxity, thinning skin, and uneven texture. It applies smoothly, dries down quickly, and layers beautifully under makeup or moisturizer, with a fresh melon scent that fades shortly after application.
Key Benefits:
Targets Five Visible Signs of Aging at Once: Human stem cell conditioned media, the first ingredient on the list, delivers a concentrated blend of growth factors that help reduce the look of wrinkles, dark spots, laxity, thinning, and rough texture in a single step.
Smooths and Tightens Skin Texture: Bis(tripeptide-1) copper acetate, a copper peptide complex, visibly firms skin and helps refine the appearance of pores and uneven surface texture over time.
Brightens and Evens Skin Tone: Sodium ascorbyl phosphate, a stable form of vitamin C, works alongside niacinamide to reduce the look of hyperpigmentation, redness, and dull, uneven tone.
Calms and Hydrates Without Heaviness: Aloe vera, green tea extract, and sodium hyaluronate deliver lightweight hydration and soothing comfort, making the serum suitable even for reactive or sensitive skin.
Clean, Professional-Grade Formula: Free of parabens, mineral oil, sulfates, phthalates, urea, DEA, and TEA. Clinically tested, allergy tested, hypoallergenic, and dermatologist tested.
If you are looking for a single serum that addresses multiple signs of aging, from fine lines and dark spots to loss of firmness and rough texture, this is designed for you. It is especially well suited if your skin shows sun damage, enlarged pores, or uneven tone and you want visible brightening and tightening without layering multiple products.
Suitable for all skin types, including sensitive and reactive skin. The lightweight gel texture absorbs quickly and works well under makeup, making it practical for both morning and evening routines.
Ideal for anyone who wants a growth factor serum with clinical-level ingredients but prefers a clean formulation free of common irritants.
Because this serum dries down so cleanly, it makes an excellent first layer in your morning routine. Apply it to bare skin, give it about 60 seconds to set, then follow with moisturizer and sunscreen. You will notice it creates a smooth, slightly tightened canvas that helps makeup sit more evenly throughout the day.
Prepare: Shake the bottle well before each use. Start with clean, dry skin.
Apply: Dispense one pump of serum and smooth it over your face and neck using gentle upward strokes.
Frequency: Use morning and night for best results. Follow with your preferred moisturizer and sunscreen during the day.
Storage: Keep in a cool, dry place away from direct sunlight to preserve the growth factor activity.
- Human Adipose Mesenchymal Stem Cell Conditioned Media: Collected output of adult adipose-derived stem cells, rich in growth factors, anti-inflammatory molecules, and signaling proteins that communicate directly with the skin's own repair mechanisms to support tissue regeneration and restore structural integrity at a cellular level.
- Copper Tripeptide-1 (GHK-Cu): Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- SNAP-8 (Acetyl Octapeptide-3): A neuropeptide that relaxes wrinkles caused in expression zones such as the forehead and eye area. Reduces wrinkle depth, smoothes, and promotes an even texture.
- Acmella Oleracea Extract: Often called the "natural Botox" ingredient, it is prized for its ability to help smooth the look of fine lines by supporting a relaxed, more even skin surface.
- Vitamin C (Sodium Ascorbyl Phosphate): Stabilized water-soluble, less acidic form of vitamin C suitable for sensitive skin and rosacea. Possesses antimicrobial properties that help diminish breakouts and inflammation.
- Camellia Sinensis Leaf Extract: A powerful antioxidant that helps defend against environmental stress, calm inflammation, and support a stronger, more resilient skin barrier.
Human Stem Cell Conditioned Media, Water (Aqua), Aloe Barbadensis Leaf Juice, Glycerin, Niacinamide, PEG8/SDMI Copolymer, Sodium Ascorbyl Phosphate, Phenoxyethanol, Hydroxyethylcellulose, Xanthan Gum, Acetyl Octapeptide-3, Acmella Oleracea Extract, Bis (Tripeptide-1) Copper Acetate, Camellia Sinensis (Green Tea) Leaf Extract, Lecithin, Polysorbate 20, Sodium Hyaluronate, Ethylhexylglycerin, Fragrance, Citric Acid, Disodium EDTA, Palmitoyl Tripeptide-37
We offer free shipping on every order $50+ (just $7 flat-rate below that). Orders placed before 1pm PST Monday through Friday ship out the same day. Orders placed outside of that window are shipped the very next business day!
Changed your mind? We get it. That's why our return window is generous: 30 days even if you've opened and tried it, or a full 60 days if it's still sealed. Some exclusions apply. See our full return policy for details.
What makes FACTORFIVE Regenerative Serum different from other anti-aging serums?
It contains the highest concentration of human stem cell conditioned media in the FACTORFIVE lineup, listed as the very first ingredient. This growth factor-rich base is paired with copper peptides, niacinamide, and a stable vitamin C to address five visible signs of aging in one serum: wrinkles, sun spots, laxity, thinning, and uneven texture.
What are the growth factors in FACTORFIVE Regenerative Serum?
The growth factors come from human stem cell conditioned media, which is the nutrient-rich liquid collected after culturing human stem cells. This media contains a complex of naturally occurring growth factors, cytokines, and proteins that help support the skin's visible renewal processes. It is the first and most concentrated ingredient in this serum.
Will FACTORFIVE Regenerative Serum work under makeup?
Yes, and this is actually one of its standout qualities. The lightweight gel texture absorbs and dries down quickly, creating a smooth, slightly firmed surface. Many users find it improves how makeup applies and wears throughout the day.
Can FACTORFIVE Regenerative Serum help with hyperpigmentation and redness?
It is specifically formulated to address uneven tone. Sodium ascorbyl phosphate, a stable vitamin C, provides a brightening effect, while niacinamide helps reduce the appearance of dark spots and visible redness over consistent use.
Is FACTORFIVE Regenerative Serum safe for sensitive skin?
Yes. The formula is clinically tested, allergy tested, hypoallergenic, and dermatologist tested. It is also free of parabens, mineral oil, sulfates, phthalates, urea, DEA, and TEA. Aloe vera and green tea extract provide additional soothing and calming support.
How long does one bottle of FACTORFIVE Regenerative Serum last?
The 1 oz bottle delivers approximately 130 to 150 pumps. When used as directed at one pump twice daily, a single bottle typically lasts 1.5 to 2 months.
What does FACTORFIVE Regenerative Serum smell like?
It has a fresh melon fragrance that is noticeable upon application but fades quickly. The scent is light and does not linger or interfere with other products in your routine.
Why buy FACTORFIVE Regenerative Serum from Art of Skin Care?
Art of Skin Care is an authorized retailer of FACTORFIVE, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if FACTORFIVE Regenerative Serum is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
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FACTORFIVE Regenerative Serum
- PGPamela G.Verified BuyerReviewingFACTORFIVE Regenerative SerumI recommend this productHow old are you? Over 65What is your skin type? DryWhat is your skin tone? FairWhat are your skin concerns? Ageing, Sensitivity, Dryness, WrinklesRated 5 out of 5 stars14 minutes agoExcellent
I hesitated to add this to my regimen because I’ve experienced sensitivity to other types of targeted anti-aging & menopausal serums. This product is very different, so I tried it. My 74 yr old sensitive skin loves it and absorbs it well & fairly quickly. I use this after toning and before my Hydrinity products. I’m loving what I see in the mirror and my skin actually feels so different - firmness, hydration, wrinkles are really improving so much over the past 3 weeks. Happy customer here!!
Was this helpful? - MVMelissa V.Verified BuyerReviewingFACTORFIVE Regenerative SerumI recommend this productHow old are you? Over 65What is your skin type? NormalWhat is your skin tone? MediumWhat are your skin concerns? Pigmentation, Redness, Sensitivity, Wrinkles, Sun DamageRated 5 out of 5 starsYesterdayPowerhouse
First time trying the FACTORFIVE skincare line. Purchased the Regenerative Serum after researching its benefits and impressive list of ingredients. A real powerhouse, addressing 5 signs of aging in one small pump. My skin looks and feels health and nourished. I've been on a mission to streamline my skincare routine, this regenerative serum is quickly moving to the top of my list.
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