Dr. esthé Rejuvenating PDRN Cream
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Dr. esthé Rejuvenating PDRN Cream is a rich, reparative cream designed to restore dry, damaged, and barrier-compromised skin through a targeted blend of cell-renewing and deeply hydrating ingredients. At the center of the formula is sodium DNA, the topical form of PDRN (polydeoxyribonucleotide) derived from salmon, which supports cellular repair and accelerates skin regeneration to help skin recover faster from damage, dryness, and environmental stress. This cream carries a subtle jasmine fragrance.
Key Benefits
Accelerates Cellular Repair Sodium DNA, the topical PDRN complex derived from salmon, activates tissue regeneration pathways to help damaged and compromised skin rebuild faster.
Reinforces the Skin Barrier Ceramide NP and cholesterol work together to replenish the lipid matrix of the skin barrier, reducing moisture loss and improving resilience against external irritants.
Delivers Deep, Lasting Hydration Sodium hyaluronate draws water into the skin while glycerin and betaine lock it in, keeping skin continuously hydrated without a heavy or greasy finish.
Calms Sensitivity and Redness Centella asiatica extract and beta-glucan reduce visible irritation and reinforce the skin's natural healing response, making this ideal for reactive or post-procedure skin.
Supports Texture Refinement Niacinamide and Lepidium meyenii (maca) root extract work together to improve overall skin texture, even skin tone, and strengthen the skin's ability to recover from stress.
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If your skin is dry, easily irritated, or has been weakened by over-exfoliation, environmental damage, or a disrupted moisture barrier, Dr. esthé Rejuvenating PDRN Cream was built for you. It delivers the level of repair and nourishment that sensitized skin needs without relying on fragranced actives or harsh ingredients that could set recovery back.
This cream is also a strong fit for anyone using active ingredients like retinoids or chemical exfoliants who want a recovery cream that can help buffer dryness and keep skin comfortable. It works especially well as an overnight treatment when the skin's natural repair cycle is most active.
Mature skin types looking to support cellular renewal and restore a firmer, more even texture will also find this cream particularly effective, given the regenerative role of the PDRN complex alongside niacinamide and maca root.
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Layer Dr. esthé Rejuvenating PDRN Cream over a retinoid on nights when your skin feels tight or reactive. The ceramide NP, sodium hyaluronate, and centella asiatica in this cream create a buffer that helps skin stay comfortable while still benefiting from the retinoid underneath.
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Prepare: Cleanse and tone before applying.
Apply: Smooth a generous layer over the face, neck, and chest.
Frequency: Use morning and evening. In the morning, always follow with a broad-spectrum SPF.
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Key Ingredients
- PDRN (Salmon DNA): A regenerative ingredient used in professional aesthetic treatments to support cellular repair and renewal. Helps improve elasticity, strengthen skin structure, and enhance visible firmness.
- Centella Asiatica Extract: Helps to strengthen and repair the skin's moisture barrier with potent anti-inflammatory benefits and antioxidant protection.
- Beta Glucan: A deeply hydrating, barrier-strengthening ingredient that helps calm redness, support skin recovery, and improve resilience, making it ideal for sensitive or acne-prone skin.
- Sodium Hyaluronate: The purest, salt form of hyaluronic acid, a master humectant that holds up to 1,000 times its weight in water to provide maximum hydration and plumping benefits to thirsty skin.
- Ceramide NP: A skin-identical ceramide that reinforces the protective barrier, helps prevent moisture loss, and improves tolerance in dry or compromised skin. Essential for restoring strength, smoothness, and long-term barrier health.
Water, Glycerin, Cetearyl Alcohol, Dipropylene Glycol, Hydrogenated Polydecene, Caprylic/Capric Triglyceride, Hydrogenated Poly (C6-14 Olefin), Beta-Glucan, Cyclohexasiloxane, Dimethiconol, 1,2Hexanediol, Niacinamide, Dicaprylyl Ether, Vegetable Oil, Glyceryl Stearate SE, Centella Asiatica Extract, Ficus Carica (Fig) Fruit Extract, Lepidium Meyenii Root Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Behenyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Polyacrylate-13, Microcrystalline Cellulose, Cetearyl Glucoside, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydrogenated Polyisobutene, Betaine, Butylene Glycol, Cholesterol, Cellulose Gum, Polyglyceryl-10 Laurate, Hydrolyzed Corn Starch, Sorbitan Isostearate, Adenosine, Ethylhexyl Palmitate, Disodium EDTA, Ceramide NP, Sucrose, Sodium DNA, Glucose, Maltodextrin, Polysorbate 60, Fragrance, Ethylhexylglycerin, Linalool
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What is PDRN in Dr. esthé Rejuvenating PDRN Cream and what does it do for skin?
PDRN stands for polydeoxyribonucleotide, and in this cream it is delivered as sodium DNA, a bioactive compound derived from salmon. It works by stimulating tissue repair at the cellular level, helping skin recover from damage, dryness, and barrier disruption more efficiently. It is the same type of regenerative ingredient used in professional aesthetic treatments, now available in a topical daily-use format.
Is Dr. esthé Rejuvenating PDRN Cream suitable for sensitive or compromised skin?
Yes, this cream is specifically formulated with reactive and barrier-damaged skin in mind. Centella asiatica extract and beta-glucan help calm visible redness and support the skin's healing response, while ceramide NP and cholesterol reinforce the lipid barrier. That said, if your skin is extremely reactive, we recommend introducing any new product gradually. You can also reach out for a free skincare consultation if you want personalized guidance.
Can Dr. esthé Rejuvenating PDRN Cream be used with retinol or other actives?
Yes, and this is one of the best ways to use it. Applying this cream over or after a retinoid helps reduce dryness and irritation without blocking the retinoid's effectiveness. The ceramide NP, glycerin, and centella asiatica work together to keep skin comfortable on active nights.
What does niacinamide do in Dr. esthé Rejuvenating PDRN Cream?
Niacinamide is a well-studied form of vitamin B3 that helps minimize the appearance of pores, reduce uneven tone, and strengthen the skin barrier over time. In this formula, it complements the reparative work of sodium DNA and ceramide NP by supporting skin tone refinement alongside barrier recovery.
What role does maca root extract play in Dr. esthé Rejuvenating PDRN Cream?
Lepidium meyenii, commonly known as maca root, is included for its ability to support the skin's adaptive response to stress and improve overall surface texture. It works in the formula as a recovery-boosting ingredient, helping skin bounce back and refine texture with continued use.
How does Dr. esthé Rejuvenating PDRN Cream support the skin barrier?
The formula combines ceramide NP and cholesterol, two key components of the skin's natural lipid barrier, to help seal moisture in and protect against external irritants. Sodium hyaluronate and glycerin add additional hydration depth, while betaine helps maintain the skin's water balance throughout the day or overnight.
When is the best time to use Dr. esthé Rejuvenating PDRN Cream?
This cream works well both morning and evening. Using it at night is particularly effective since skin undergoes its natural repair cycle during sleep, and the PDRN complex and ceramide NP can work with that process. In the morning, always follow with a broad-spectrum SPF to protect the skin you are working to repair.
Why buy Dr. esthé Rejuvenating PDRN Cream from Art of Skin Care?
Art of Skin Care is an authorized retailer of Dr. esthé, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if Dr. esthé Rejuvenating PDRN Cream is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
Dr. esthé Rejuvenating PDRN Cream is a rich, reparative cream designed to restore dry, damaged, and barrier-compromised skin through a targeted blend of cell-renewing and deeply hydrating ingredients. At the center of the formula is sodium DNA, the topical form of PDRN (polydeoxyribonucleotide) derived from salmon, which supports cellular repair and accelerates skin regeneration to help skin recover faster from damage, dryness, and environmental stress. This cream carries a subtle jasmine fragrance.
Key Benefits
Accelerates Cellular Repair Sodium DNA, the topical PDRN complex derived from salmon, activates tissue regeneration pathways to help damaged and compromised skin rebuild faster.
Reinforces the Skin Barrier Ceramide NP and cholesterol work together to replenish the lipid matrix of the skin barrier, reducing moisture loss and improving resilience against external irritants.
Delivers Deep, Lasting Hydration Sodium hyaluronate draws water into the skin while glycerin and betaine lock it in, keeping skin continuously hydrated without a heavy or greasy finish.
Calms Sensitivity and Redness Centella asiatica extract and beta-glucan reduce visible irritation and reinforce the skin's natural healing response, making this ideal for reactive or post-procedure skin.
Supports Texture Refinement Niacinamide and Lepidium meyenii (maca) root extract work together to improve overall skin texture, even skin tone, and strengthen the skin's ability to recover from stress.
If your skin is dry, easily irritated, or has been weakened by over-exfoliation, environmental damage, or a disrupted moisture barrier, Dr. esthé Rejuvenating PDRN Cream was built for you. It delivers the level of repair and nourishment that sensitized skin needs without relying on fragranced actives or harsh ingredients that could set recovery back.
This cream is also a strong fit for anyone using active ingredients like retinoids or chemical exfoliants who want a recovery cream that can help buffer dryness and keep skin comfortable. It works especially well as an overnight treatment when the skin's natural repair cycle is most active.
Mature skin types looking to support cellular renewal and restore a firmer, more even texture will also find this cream particularly effective, given the regenerative role of the PDRN complex alongside niacinamide and maca root.
Layer Dr. esthé Rejuvenating PDRN Cream over a retinoid on nights when your skin feels tight or reactive. The ceramide NP, sodium hyaluronate, and centella asiatica in this cream create a buffer that helps skin stay comfortable while still benefiting from the retinoid underneath.
Prepare: Cleanse and tone before applying.
Apply: Smooth a generous layer over the face, neck, and chest.
Frequency: Use morning and evening. In the morning, always follow with a broad-spectrum SPF.
- PDRN (Salmon DNA): A regenerative ingredient used in professional aesthetic treatments to support cellular repair and renewal. Helps improve elasticity, strengthen skin structure, and enhance visible firmness.
- Centella Asiatica Extract: Helps to strengthen and repair the skin's moisture barrier with potent anti-inflammatory benefits and antioxidant protection.
- Beta Glucan: A deeply hydrating, barrier-strengthening ingredient that helps calm redness, support skin recovery, and improve resilience, making it ideal for sensitive or acne-prone skin.
- Sodium Hyaluronate: The purest, salt form of hyaluronic acid, a master humectant that holds up to 1,000 times its weight in water to provide maximum hydration and plumping benefits to thirsty skin.
- Ceramide NP: A skin-identical ceramide that reinforces the protective barrier, helps prevent moisture loss, and improves tolerance in dry or compromised skin. Essential for restoring strength, smoothness, and long-term barrier health.
Water, Glycerin, Cetearyl Alcohol, Dipropylene Glycol, Hydrogenated Polydecene, Caprylic/Capric Triglyceride, Hydrogenated Poly (C6-14 Olefin), Beta-Glucan, Cyclohexasiloxane, Dimethiconol, 1,2Hexanediol, Niacinamide, Dicaprylyl Ether, Vegetable Oil, Glyceryl Stearate SE, Centella Asiatica Extract, Ficus Carica (Fig) Fruit Extract, Lepidium Meyenii Root Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Behenyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Polyacrylate-13, Microcrystalline Cellulose, Cetearyl Glucoside, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydrogenated Polyisobutene, Betaine, Butylene Glycol, Cholesterol, Cellulose Gum, Polyglyceryl-10 Laurate, Hydrolyzed Corn Starch, Sorbitan Isostearate, Adenosine, Ethylhexyl Palmitate, Disodium EDTA, Ceramide NP, Sucrose, Sodium DNA, Glucose, Maltodextrin, Polysorbate 60, Fragrance, Ethylhexylglycerin, Linalool
What is PDRN in Dr. esthé Rejuvenating PDRN Cream and what does it do for skin?
PDRN stands for polydeoxyribonucleotide, and in this cream it is delivered as sodium DNA, a bioactive compound derived from salmon. It works by stimulating tissue repair at the cellular level, helping skin recover from damage, dryness, and barrier disruption more efficiently. It is the same type of regenerative ingredient used in professional aesthetic treatments, now available in a topical daily-use format.
Is Dr. esthé Rejuvenating PDRN Cream suitable for sensitive or compromised skin?
Yes, this cream is specifically formulated with reactive and barrier-damaged skin in mind. Centella asiatica extract and beta-glucan help calm visible redness and support the skin's healing response, while ceramide NP and cholesterol reinforce the lipid barrier. That said, if your skin is extremely reactive, we recommend introducing any new product gradually. You can also reach out for a free skincare consultation if you want personalized guidance.
Can Dr. esthé Rejuvenating PDRN Cream be used with retinol or other actives?
Yes, and this is one of the best ways to use it. Applying this cream over or after a retinoid helps reduce dryness and irritation without blocking the retinoid's effectiveness. The ceramide NP, glycerin, and centella asiatica work together to keep skin comfortable on active nights.
What does niacinamide do in Dr. esthé Rejuvenating PDRN Cream?
Niacinamide is a well-studied form of vitamin B3 that helps minimize the appearance of pores, reduce uneven tone, and strengthen the skin barrier over time. In this formula, it complements the reparative work of sodium DNA and ceramide NP by supporting skin tone refinement alongside barrier recovery.
What role does maca root extract play in Dr. esthé Rejuvenating PDRN Cream?
Lepidium meyenii, commonly known as maca root, is included for its ability to support the skin's adaptive response to stress and improve overall surface texture. It works in the formula as a recovery-boosting ingredient, helping skin bounce back and refine texture with continued use.
How does Dr. esthé Rejuvenating PDRN Cream support the skin barrier?
The formula combines ceramide NP and cholesterol, two key components of the skin's natural lipid barrier, to help seal moisture in and protect against external irritants. Sodium hyaluronate and glycerin add additional hydration depth, while betaine helps maintain the skin's water balance throughout the day or overnight.
When is the best time to use Dr. esthé Rejuvenating PDRN Cream?
This cream works well both morning and evening. Using it at night is particularly effective since skin undergoes its natural repair cycle during sleep, and the PDRN complex and ceramide NP can work with that process. In the morning, always follow with a broad-spectrum SPF to protect the skin you are working to repair.
Why buy Dr. esthé Rejuvenating PDRN Cream from Art of Skin Care?
Art of Skin Care is an authorized retailer of Dr. esthé, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if Dr. esthé Rejuvenating PDRN Cream is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
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Dr. esthé Rejuvenating PDRN Cream
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- ABAlexis B.Verified BuyerReviewingDr. esthé Rejuvenating PDRN CreamI recommend this productHow old are you? 50-65What is your skin type? DryWhat is your skin tone? TanWhat are your skin concerns? Ageing, Blemish-prone, DrynessRated 4 out of 5 stars1 month agoBest moisturizer ever!!
I have very dry skin and this product has kept my skin moist and plump!! I will never go without this product!!
Was this helpful? - WBWilliam B.Verified BuyerReviewingDr. esthé Rejuvenating PDRN CreamI recommend this productHow old are you? 50-65What is your skin type? CombinationWhat is your skin tone? FairWhat are your skin concerns? Ageing, Pigmentation, Redness, Sensitivity, WrinklesRated 5 out of 5 stars4 months agoOutstanding product!
This brand is my go to! My favorite!
Was this helpful? - SBShelley B.Verified BuyerReviewingDr. esthé Rejuvenating PDRN CreamI recommend this productHow old are you? 50-65What is your skin type? NormalWhat is your skin tone? MediumWhat are your skin concerns? AgeingRated 5 out of 5 stars1 year agoDr eshte Rejuvenating Cream
I love this cream. My face feels so hydrated after using.
Was this helpful? - JJJVerified BuyerReviewingDr. esthé Rejuvenating PDRN CreamI recommend this productHow old are you? 18-29What is your skin type? CombinationWhat is your skin tone? TanWhat are your skin concerns? Dryness, Sun Damage, Sensitivity, PigmentationRated 5 out of 5 stars1 year agoDr Esthe Rejuvenating Cream
Another favorite of mine. I use the cream during the day time, ampoule and toner for my nighttime routine. I find that it works really well for me in that order without doing too much. I’ve only been using this entire line for a little over a week and I’ve already seen some improvement in my skin’s tone and texture.
Was this helpful? - CKcindy k.Verified BuyerReviewingDr. esthé Rejuvenating PDRN CreamI recommend this productHow old are you? Over 65What is your skin type? CombinationWhat is your skin tone? FairWhat are your skin concerns? Redness, AgeingRated 5 out of 5 stars1 year agoLove my skin cream!
I love this rejuvenating cream! It's an absolute value! You only need a small amount, it lasts a long time! My skin feels smoother and I get so many complements on it!
Thank you!!
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