FREE U.S. SHIPPING ON ORDERS $49+

Peptide Skincare

Peptides are one of the most effective ingredients for firming, smoothing fine lines, and supporting healthier-looking skin over time. These skin-communication ingredients help support collagen and elastin while strengthening the barrier for improved resilience.

Shop our estheticians’ top peptide picks below.

Frequently Asked Questions

What is the best peptide serum for wrinkles?

The best peptide serum for wrinkles is one that contains multiple proven peptides designed to support collagen, improve firmness, and soften the look of expression lines. Consistent daily use is key for visible results.

What is the best peptide moisturizer for aging skin?

A peptide moisturizer is ideal for aging skin when it combines firming peptides with barrier-supporting ingredients to improve elasticity, hydration, and skin resilience. It’s a great option for clients who want anti-aging support in one simple step. Two of our top picks are Rhonda Alison Amino Peptide Hydration and Circadia Phito-Pep 1.6

Can I use peptides with niacinamide?

Yes. Peptides and niacinamide work very well together. This pairing supports a stronger skin barrier, smoother texture, and improved overall tone without irritation.

Can I use peptides with hyaluronic acid?


Yes. Hyaluronic acid hydrates and plumps the skin, while peptides support firmness and long-term resilience. This is one of the best combinations for dry or aging skin. If you’re looking for a serum that delivers both, Michele Corley Rejuvenating Peptide & Stem Cell Facial Serum. is one of our favorites for plumping hydration and smoothing the look of fine lines.

Can I use peptides with exfoliating acids (glycolic, lactic, salicylic)?

In most cases, yes — but it depends on your skin’s sensitivity. If you use exfoliating acids, peptides are a great follow-up ingredient because they help support the skin and reduce the chance of irritation.

Can I use peptides with vitamin C in the same routine?

Yes. Most people can use peptides and vitamin C together. If your skin is sensitive, vitamin C in the morning and peptides at night is a simple and effective approach. If you’re looking for a gentle, beautifully balanced vitamin C option, we love Emepelle Serum, which combines vitamin C with hyaluronic acid and niacinamide to support brighter, more resilient skin.

What should you not mix with peptides?

Peptides are generally compatible with most skincare ingredients. The main concern is using them in routines that are too harsh or over-exfoliating, which can compromise the skin barrier and reduce overall results.

Are peptide serums good for sensitive skin?

Yes. Peptide serums are often an excellent choice for sensitive skin because they support firmness and repair without the irritation commonly associated with stronger anti-aging ingredients. If your skin is easily reactive, we love Hydrinity Restorative HA Serum for soothing hydration and barrier support while still delivering visible skin-strengthening benefits.



Are peptides good for menopausal skin?

Yes. Peptides are one of the best ingredients for menopausal skin because they support firmness, elasticity, and skin density while helping strengthen the barrier as skin becomes thinner and drier with age. Two of our favorite multi-function options are Emepelle Serum, which combines peptides with MEP to help address visible changes related to estrogen loss, and Emepelle Night Cream, which blends peptides, retinol, and MEP for advanced overnight renewal and firming support.

Do peptides help with crepey skin?

Yes. Peptides can help improve the look of crepey skin by supporting collagen, improving elasticity, and strengthening the skin’s structure. One of our favorites is Circadia Cyto-Comm, featuring Trifluoroacetyl Tripeptide-2, an advanced firming peptide that supports elasticity and smoother-looking skin.

28 Results

KrX Aesthetics Active-31 Revitalizing Eye Cream 15ml white tube with silver band and precision tip nozzle for targeted eye area application
KrX Active 31 Revitalizing Eye Cream - Art of Skin Care
Acne Safe

KrX Active 31 Revitalizing Eye Cream

5.0 (13)

$46.00

Unit price
per 

SHOP NOW
Rhonda Allison Pro Youth 10 C-Peptide Complex 20% C-Power vitamin C serum in a 15mL clear airless pump bottle with white cap and black and silver label on a light gray background
Rhonda Allison C - Peptide Complex - Art of Skin Care
Acne Safe

Rhonda Allison C-Peptide Complex

4.7 (39)

$80.00

Unit price
per 

SHOP NOW
Emepelle Night Cream for estrogen-deficient skin – white jar with silver lid and rose gold accent band
Emepelle Estrogen Deficient Skin Set - Art of Skin Care

Emepelle Night Cream

4.8 (28)

$195.00

Unit price
per 

SHOP NOW
Rhonda Allison Pro Youth 10 Peptide 38 Elite Collagen Cocktail 30 mL in a clear airless pump bottle with white cap and black and white botanical label on a light gray background
Rhonda Allison Peptide 38 - Art of Skin Care
Acne Safe

Rhonda Allison Peptide 38

5.0 (17)

$102.00

Unit price
per 

SHOP NOW
Dr.esthé M.G.F. Renewal Solution Ampoule 150ml purple glass dropper bottle with 88% snail secretion filtrate, 4GF Complex, peptide complex, and 5000ppm goat milk for advanced regenerating
Dr. esthé MGF Renewal Solution Ampoule - Art of Skin Care
Acne Safe

Dr. esthé MGF Renewal Solution Ampoule

4.9 (63)

from $110.00

Unit price
per 

SHOP NOW
Le Mieux Cryo Peptide Eye Mask cooling and depuffing under-eye patches – white box with inner refill pouch, 4 pairs / 0.17 oz each
Le Mieux Cryo-Peptide Eye Mask under-eye patches showing two pairs of white crescent-shaped eye patches on backing sheet. Available at Art of Skin Care
New

Le Mieux Cryo Peptide Eye Mask

4.9 (7)

from $4.50

Unit price
per 

SHOP NOW
GlyMed Plus Elite Atraxi Peptide in white pump bottle with silver pump and purple label, 1.69 oz, on light gray background
swatch of GlyMed Plus Atraxi Peptide cream on a white background
Acne Safe

GlyMed Plus Atraxi Peptide

4.7 (15)

$160.00

Unit price
per 

SHOP NOW
Emepelle Eye Cream for estrogen-deficient skin – white airless pump bottle with silver cap and rose gold accent band
Emepelle Eye Cream - Art of Skin Care
Acne Safe

Emepelle Eye Cream

4.9 (62)

$98.00

Unit price
per 

SHOP NOW
Michele Corley Clinical Skin Care Hydrating Peptide Cream 2 fl oz (60ml) - Acne Safe formula in white pump bottle
Acne Safe
New

Michele Corley Hydrating Peptide Cream

4.7 (6)

$46.00

Unit price
per 

SHOP NOW