The Serums I Trust Most — At Every Age
Regenerative skincare for skin that's ready to do more than just hold on.
After 20 years in esthetics, I've watched the skincare conversation shift in a way that genuinely excites me. We're no longer chasing the appearance of youth. We're restoring the biology of it.
This collection is the heart of what I recommend most, and what I use myself. NeoGenesis, Plated Skin Science, FactorFive — these aren't trend products. They're tools that work with your skin's own cellular intelligence. Growth factors that signal repair. Exosomes that carry renewal instructions directly into your cells. Stem cell technology that doesn't just hydrate. It communicates.
Skin at 40, 50, 60, 70 doesn't need to be fought. It needs to be understood.
Every serum in this collection was chosen because it earns its place in a serious routine. If you want to see exactly how I use these products in my own skin, the protocols, the philosophy, and what I've learned after two decades in this industry, that's where to start.
Read: How I care for My Skin at 63; Regenerative, Not Aggressive →
Why is regenerative skin care important?
Which regenerative serum is right for me?
What are growth factors in skincare?
Growth factors are naturally occurring proteins that act as cellular messengers. They signal skin cells to:
- Repair damage
- Regenerate new cells
- Produce collagen and elastin
In skincare, growth factors help improve texture, firmness, healing, and overall skin vitality—especially for aging or compromised skin.
What is stem cell–released media, and why is it beneficial?
Stem cell–released media is a nutrient-rich blend of regenerative signaling molecules produced by adult stem cells in a lab setting. These molecules support:
- Skin repair and healing
- Barrier strengthening
- Inflammation reduction
- Improved hydration and resilience
Because it delivers a broad spectrum of signals, it’s especially beneficial for sensitive, damaged, or post-procedure skin.
What are exosomes in skincare?
Exosomes are microscopic extracellular vesicles that act as advanced messengers between cells. They deliver highly targeted instructions that help optimize skin repair, regeneration, and collagen production.
Exosomes enhance cell-to-cell communication, making them one of the most advanced technologies in regenerative skincare.
How are exosomes different from growth factors?
Growth factors send single, specific signals to skin cells.
Exosomes deliver multiple bioactive messages at once, including peptides, antioxidants, and signaling molecules—making them more comprehensive and efficient.
Think of growth factors as a single instruction, and exosomes as a full training manual.
What are Extremozymes®?
Extremozymes®, found in many iS Clinical serums, are protective enzymes that help your skin defend itself against everyday stress like sun exposure, pollution, and dryness. They support your skin’s natural repair process, helping keep skin strong, healthy, and resilient over time.
In skincare, Extremozymes® help:
- Protect skin from environmental damage
- Support healthy skin cells
- Strengthen the skin barrier
- Promote smoother, more resilient-looking skin
Can I use growth factors, stem cells, and exosomes together?
Yes—and in many cases, they complement each other beautifully.
Growth factors provide targeted messaging, stem cell–released media supports holistic repair, and exosomes optimize delivery and communication. Using them strategically can enhance overall results. In general, we recommend applying growth factors or stem cells cytokines first and then exosomes on top.
What is glycation?
Glycation is a biochemical process where excess sugar in the bloodstream binds to collagen and elastin, forming harmful compounds called AGEs (Advanced Glycation End Products). These AGEs weaken your skin’s structure, leading to wrinkles, sagging, and a rough “orange peel” texture. Glycation accelerates aging and is influenced by sugar intake, alcohol, stress, UV exposure, and metabolic health.
Learn more about glycation: What is Glycation? How Sugar Affects Your Skin (and what to do about it)>
What skincare products help reduce glycation?
Look for formulas containing anti-glycation and collagen-supporting actives. All of our regenerative serums are helpful. Some of our top recommendations include:
- Circadia Counter A.G.E. (antioxidants + anti-glycation peptides + carnosine)
- Circadia Cyto-Comm (advanced complex of anti-glycation peptides + cellular communicators)
- Circadia Glyco-Guard (provides antioxidants + detoxification activities to promote connective tissue preservation)
- Rhonda Allison AGE Less - (antioxidants + collagen repairing peptides) rich serum that strengthens skin and restores damaged collagen.
- NeoGenesis Recovery (growth factors + repair molecules)
- iS Clinical Retinol Emulsion 0.3% (collagen renewal)
Consistency is key for visible improvement.
