Rhonda Allison Bio 53 Matrix Plus
Lightweight cooling serum with epidermal growth factor that strengthens, renews, and calms depleted, retinoid-stressed, or aging skin.
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Rhonda Allison Bio 53 Matrix Plus is a lightweight, cooling serum formulated to support depleted, compromised, or treatment-prepped skin with the rejuvenating power of epidermal growth factor (EGF) and chondroitin. This serum delivers strengthening, anti-inflammatory support while encouraging healthy cellular renewal, making it an ideal companion for those using prescription retinoids like tretinoin or preparing for advanced corrective treatments. A subtle, fresh botanical note from peppermint and chlorophyll gives it a clean, spa-like finish on the skin.
Same Formula as Growth Factor Serum Plus and Cell Renewal SerumKey Benefits
Stimulates Healthy Cellular Renewal rh-Oligopeptide-1 (EGF) signals skin to produce fresh, healthy cells, helping restore density, resilience, and a smoother surface to tired, depleted complexions.
Strengthens and Fortifies the Skin Barrier Sodium chondroitin sulfate and phospholipids reinforce the skin's matrix, improving hydration retention and supporting firmness in skin weakened by active treatments or aging.
Calms Redness and Inflammation Bisabolol, allantoin, licorice root, and aloe work together to quiet irritation, making this serum an excellent partner for post-peel, post-retinoid, or sensitized skin.
Delivers Powerful Antioxidant Defense Fullerene, green tea leaf extract, and chlorophyll neutralize free radicals and protect skin from environmental stressors that accelerate visible aging.
Cools and Soothes on Contact A touch of peppermint oil and witch hazel water gives an instantly refreshing, cooling sensation that feels especially welcome on heated, reactive, or treatment-stressed skin.
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Bio 53 Matrix Plus is ideal for anyone using prescription-strength topicals like tretinoin, preparing for chemical peels or advanced corrective treatments, or recovering from procedures that leave skin feeling depleted and reactive. If your skin feels thin, inflamed, or slow to bounce back, this serum provides the strengthening and calming support it needs.
It is also well-suited for aging or mature skin showing signs of fatigue, loss of firmness, or dullness. The combination of EGF and chondroitin helps reinforce skin structure while encouraging a healthier, more resilient appearance.
Sensitive, redness-prone, and compromised skin types will also appreciate the anti-inflammatory botanicals that soothe on contact without heavy occlusive ingredients.
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If you are using prescription retinoids or recovering from a peel, apply Bio 53 Matrix Plus immediately after cleansing while the skin is still slightly damp. This helps the EGF and chondroitin penetrate more effectively and amplifies the cooling, calming effect on inflamed tissue.
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Prepare: Cleanse and tone the skin, leaving it clean and dry.
Apply: Dispense 1 to 2 pumps onto fingertips and gently press into the face and neck.
Technique: Use alone as a treatment serum or layer under your preferred Rhonda Allison moisturizer for added nourishment.
Frequency: Use morning and evening, or as directed by your esthetician.
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Key Ingredients
- EGF (proprietary formula): Epidermal growth factor targets damaged, inflamed and mature skin to promote skin renewal and healing.
- Sodium Chondroitin Sulfate (Bovine Soluble Trachea Powder): A naturally occurring mucopolysaccharide found in connective tissue, including skin, this potent ingredient reinforces the intercellular matrix within the skin while reducing inflammation; strengthens and soothes skin, increases hydration and promotes healing.
- Squalane: Keeps skin hydrated and balances oil production by mimicking the skin’s acid mantle while also reducing inflammation, soothing skin irritation, and improving elasticity.
- Phenyl-t-Butylnitrone (Spin Trap): An intelligent and powerful antioxidant compound that targets and traps free radicals to convert them into useful oxygen, and transports back into the respiratory cycle.
- Bisabolol: Skin-soothing agent with anti-inflammatory and antimicrobial properties.
- Crocus Chrysanthus Bulb Extract: Helps improve cellular communication, renews skin’s resilience, and rejuvenates texture.
Aqua (Water), Glycerin, Propanediol, Squalane, Crocus Chrysanthus Bulb Extract, rh-Oligopeptide-1 (EGF), Chlorophyllin-Copper Complex, Carbomer, Leuconostoc/Radish Root Ferment Filtrate, Collagen, Bisabolol (L-alpha), Sodium Hydroxide, Ricinus Communis (Castor) Seed Oil*, Sodium Chondroitin Sulfate, Allantoin, Sodium Gluconate, Santalum Austrocaledonicum (Sandalwood) Wood Oil, Caprylhydroxamic Acid, Xanthan Gum, Glycyrrhiza Glabra (Licorice) Rhizome/Root Extract, Glucuronolactone (D), Cinnamomum Camphora (Camphor) Bark Oil, Pogostemon Cablin (Patchouli) Oil, Phospholipids, Aloe Barbadensis Leaf Juice Powder, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Camellia Sinensis (Green Tea) Leaf Extract, Hamamelis Virginiana (Witch Hazel) Water, Citric Acid, Citrus Paradisi (Pink Grapefruit) Peel Oil, Alcohol, Acacia Senegal Gum, Mentha Piperita (Peppermint) Oil, Alcohol Denat., Benzyl Alcohol, Fullerenes
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What does Rhonda Allison Bio 53 Matrix Plus do for the skin?
Bio 53 Matrix Plus delivers epidermal growth factor and chondroitin to strengthen, renew, and calm the skin. It supports healthy cellular turnover, reduces inflammation, and fortifies skin weakened by aging, active treatments, or sensitivity. Expect a more resilient, refreshed, and balanced complexion with consistent use.
Is Rhonda Allison Bio 53 Matrix Plus safe to use with tretinoin or prescription retinoids?
Yes, this serum is specifically well-suited for those using tretinoin or other prescription topicals. The EGF, chondroitin, and soothing botanicals like bisabolol and allantoin help counteract the inflammation, dryness, and barrier disruption that often accompany retinoid use.
How does the epidermal growth factor in Rhonda Allison Bio 53 Matrix Plus work?
rh-Oligopeptide-1, also known as EGF, is a bio-signaling protein that communicates with skin cells to promote healthy renewal and repair. It helps restore skin density, smooth texture, and improve overall tone, making it especially valuable for depleted or aging skin.
When should I apply Rhonda Allison Bio 53 Matrix Plus in my routine?
Apply after cleansing and toning, before moisturizer. Use 1 to 2 pumps morning and evening. If layering with other serums, Bio 53 Matrix Plus should go on first so the growth factors can absorb directly into clean, dry skin.
Can Rhonda Allison Bio 53 Matrix Plus be used on sensitive or reactive skin?
Absolutely. The formula includes calming ingredients like bisabolol, licorice root, aloe, and allantoin that help quiet redness and irritation. The cooling, lightweight texture makes it comfortable on compromised or post-procedure skin.
Does Rhonda Allison Bio 53 Matrix Plus contain fragrance?
The formula contains a small amount of fragrance along with peppermint oil, which contributes to its signature cooling sensation. If your skin is extremely fragrance-sensitive, we recommend booking a free skincare consultation to explore the best fit.
How long does one bottle of Rhonda Allison Bio 53 Matrix Plus typically last?
With twice-daily use of 1 to 2 pumps, most users find the serum lasts approximately 2 to 3 months. Using it as a targeted treatment rather than all-over application will extend the life of the bottle.
Why buy Rhonda Allison Bio 53 Matrix Plus from Art of Skin Care?
Art of Skin Care is an authorized retailer of Rhonda Allison, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if Rhonda Allison Bio 53 Matrix Plus is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
Rhonda Allison Bio 53 Matrix Plus is a lightweight, cooling serum formulated to support depleted, compromised, or treatment-prepped skin with the rejuvenating power of epidermal growth factor (EGF) and chondroitin. This serum delivers strengthening, anti-inflammatory support while encouraging healthy cellular renewal, making it an ideal companion for those using prescription retinoids like tretinoin or preparing for advanced corrective treatments. A subtle, fresh botanical note from peppermint and chlorophyll gives it a clean, spa-like finish on the skin.
Same Formula as Growth Factor Serum Plus and Cell Renewal Serum
Key Benefits
Stimulates Healthy Cellular Renewal rh-Oligopeptide-1 (EGF) signals skin to produce fresh, healthy cells, helping restore density, resilience, and a smoother surface to tired, depleted complexions.
Strengthens and Fortifies the Skin Barrier Sodium chondroitin sulfate and phospholipids reinforce the skin's matrix, improving hydration retention and supporting firmness in skin weakened by active treatments or aging.
Calms Redness and Inflammation Bisabolol, allantoin, licorice root, and aloe work together to quiet irritation, making this serum an excellent partner for post-peel, post-retinoid, or sensitized skin.
Delivers Powerful Antioxidant Defense Fullerene, green tea leaf extract, and chlorophyll neutralize free radicals and protect skin from environmental stressors that accelerate visible aging.
Cools and Soothes on Contact A touch of peppermint oil and witch hazel water gives an instantly refreshing, cooling sensation that feels especially welcome on heated, reactive, or treatment-stressed skin.
Bio 53 Matrix Plus is ideal for anyone using prescription-strength topicals like tretinoin, preparing for chemical peels or advanced corrective treatments, or recovering from procedures that leave skin feeling depleted and reactive. If your skin feels thin, inflamed, or slow to bounce back, this serum provides the strengthening and calming support it needs.
It is also well-suited for aging or mature skin showing signs of fatigue, loss of firmness, or dullness. The combination of EGF and chondroitin helps reinforce skin structure while encouraging a healthier, more resilient appearance.
Sensitive, redness-prone, and compromised skin types will also appreciate the anti-inflammatory botanicals that soothe on contact without heavy occlusive ingredients.
If you are using prescription retinoids or recovering from a peel, apply Bio 53 Matrix Plus immediately after cleansing while the skin is still slightly damp. This helps the EGF and chondroitin penetrate more effectively and amplifies the cooling, calming effect on inflamed tissue.
Prepare: Cleanse and tone the skin, leaving it clean and dry.
Apply: Dispense 1 to 2 pumps onto fingertips and gently press into the face and neck.
Technique: Use alone as a treatment serum or layer under your preferred Rhonda Allison moisturizer for added nourishment.
Frequency: Use morning and evening, or as directed by your esthetician.
- EGF (proprietary formula): Epidermal growth factor targets damaged, inflamed and mature skin to promote skin renewal and healing.
- Sodium Chondroitin Sulfate (Bovine Soluble Trachea Powder): A naturally occurring mucopolysaccharide found in connective tissue, including skin, this potent ingredient reinforces the intercellular matrix within the skin while reducing inflammation; strengthens and soothes skin, increases hydration and promotes healing.
- Squalane: Keeps skin hydrated and balances oil production by mimicking the skin’s acid mantle while also reducing inflammation, soothing skin irritation, and improving elasticity.
- Phenyl-t-Butylnitrone (Spin Trap): An intelligent and powerful antioxidant compound that targets and traps free radicals to convert them into useful oxygen, and transports back into the respiratory cycle.
- Bisabolol: Skin-soothing agent with anti-inflammatory and antimicrobial properties.
- Crocus Chrysanthus Bulb Extract: Helps improve cellular communication, renews skin’s resilience, and rejuvenates texture.
Aqua (Water), Glycerin, Propanediol, Squalane, Crocus Chrysanthus Bulb Extract, rh-Oligopeptide-1 (EGF), Chlorophyllin-Copper Complex, Carbomer, Leuconostoc/Radish Root Ferment Filtrate, Collagen, Bisabolol (L-alpha), Sodium Hydroxide, Ricinus Communis (Castor) Seed Oil*, Sodium Chondroitin Sulfate, Allantoin, Sodium Gluconate, Santalum Austrocaledonicum (Sandalwood) Wood Oil, Caprylhydroxamic Acid, Xanthan Gum, Glycyrrhiza Glabra (Licorice) Rhizome/Root Extract, Glucuronolactone (D), Cinnamomum Camphora (Camphor) Bark Oil, Pogostemon Cablin (Patchouli) Oil, Phospholipids, Aloe Barbadensis Leaf Juice Powder, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Camellia Sinensis (Green Tea) Leaf Extract, Hamamelis Virginiana (Witch Hazel) Water, Citric Acid, Citrus Paradisi (Pink Grapefruit) Peel Oil, Alcohol, Acacia Senegal Gum, Mentha Piperita (Peppermint) Oil, Alcohol Denat., Benzyl Alcohol, Fullerenes
What does Rhonda Allison Bio 53 Matrix Plus do for the skin?
Bio 53 Matrix Plus delivers epidermal growth factor and chondroitin to strengthen, renew, and calm the skin. It supports healthy cellular turnover, reduces inflammation, and fortifies skin weakened by aging, active treatments, or sensitivity. Expect a more resilient, refreshed, and balanced complexion with consistent use.
Is Rhonda Allison Bio 53 Matrix Plus safe to use with tretinoin or prescription retinoids?
Yes, this serum is specifically well-suited for those using tretinoin or other prescription topicals. The EGF, chondroitin, and soothing botanicals like bisabolol and allantoin help counteract the inflammation, dryness, and barrier disruption that often accompany retinoid use.
How does the epidermal growth factor in Rhonda Allison Bio 53 Matrix Plus work?
rh-Oligopeptide-1, also known as EGF, is a bio-signaling protein that communicates with skin cells to promote healthy renewal and repair. It helps restore skin density, smooth texture, and improve overall tone, making it especially valuable for depleted or aging skin.
When should I apply Rhonda Allison Bio 53 Matrix Plus in my routine?
Apply after cleansing and toning, before moisturizer. Use 1 to 2 pumps morning and evening. If layering with other serums, Bio 53 Matrix Plus should go on first so the growth factors can absorb directly into clean, dry skin.
Can Rhonda Allison Bio 53 Matrix Plus be used on sensitive or reactive skin?
Absolutely. The formula includes calming ingredients like bisabolol, licorice root, aloe, and allantoin that help quiet redness and irritation. The cooling, lightweight texture makes it comfortable on compromised or post-procedure skin.
Does Rhonda Allison Bio 53 Matrix Plus contain fragrance?
The formula contains a small amount of fragrance along with peppermint oil, which contributes to its signature cooling sensation. If your skin is extremely fragrance-sensitive, we recommend booking a free skincare consultation to explore the best fit.
How long does one bottle of Rhonda Allison Bio 53 Matrix Plus typically last?
With twice-daily use of 1 to 2 pumps, most users find the serum lasts approximately 2 to 3 months. Using it as a targeted treatment rather than all-over application will extend the life of the bottle.
Why buy Rhonda Allison Bio 53 Matrix Plus from Art of Skin Care?
Art of Skin Care is an authorized retailer of Rhonda Allison, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if Rhonda Allison Bio 53 Matrix Plus is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
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Rhonda Allison Bio 53 Matrix Plus
- Sensory
- Benefits
- AHAstin H.Verified BuyerReviewingRhonda Allison Bio 53 Matrix PlusI recommend this productHow old are you? 30-39What is your skin type? DryWhat is your skin tone? FairWhat are your skin concerns? Ageing, Blemish-prone, Sensitivity, Acne, DrynessRated 5 out of 5 stars5 months agoa fave!
i use this after my mandelic serum, before my moisturizer and my skin is so soft with this! i love the cooling feeling and how healthy my skin looks. this is one of, if not my favorite skincare item i use currently. highly recommend if it fits what you’re looking for!
Was this helpful? - CCoryVerified BuyerReviewingRhonda Allison Bio 53 Matrix PlusI recommend this productHow old are you? 30-39What is your skin type? CombinationWhat is your skin tone? FairWhat are your skin concerns? Blemish-prone, Pigmentation, AgeingRated 5 out of 5 stars9 months agoGreat Product
I love following up my mandelic rejuvenator with this. It has a great smell and even a “cooling” sensation. Has truly helped my skin.
Was this helpful? - ERElizabeth R.Verified BuyerReviewingRhonda Allison Bio 53 Matrix PlusI recommend this productHow old are you? Over 65What is your skin type? DryWhat is your skin tone? MediumWhat are your skin concerns? Dryness, Wrinkles, AgeingRated 5 out of 5 stars1 year agoAmazing serum
I totally am smitten with this product. The smell and feel on my skin as it works it’s manic just is so appealing . You can not go wrong with this anti aging product !
Was this helpful? - LLizReviewingRhonda Allison Bio 53 Matrix PlusI recommend this productRated 5 out of 5 stars1 year ago5 Stars
Amazing as usual! I have used this for YEARS! I am switching to Art of Skincare because they ship much faster than the other site I have been using.
Was this helpful? - SAStacy A.Verified BuyerReviewingRhonda Allison Bio 53 Matrix PlusI recommend this productHow old are you? 50-65Rated 5 out of 5 stars1 year agoRhonda Allison Bio 53 Matrix Plus
Great Serum
This is one of my favorite serums from RA. I alternate between DNA Reversal and this. It makes my skin feel so nourished when I put it on. I put a little (one pump) in my hands and then pat it on my face. A little goes a long way and my skin loves it.
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