Epicutis Lipid Serum dropper bottle and Hyvia Crème closed glass jar luxury skincare set, on a light gray background

Epicutis Lipid Serum dropper bottle and Hyvia Crème open glass jar luxury skincare set with lid off, on a light gray background

Before and after comparison of a woman's face using Epicutis product.

Before and after comparison of a woman's face using Epicutis Simple System, showing visible skin improvement.

Before and after comparison of a person's face using Epicutis product showing greatly reduced redness

Epicutis Luxury Essentials Set - Art of Skin Care

Epicutis Luxury Skincare Set

Name: Epicutis Luxury Skincare Set
Brand: Epicutis
Price: 395.0 USD
Availability: InStock
Rating: 4.9 (29 reviews)

Epicutis

A barrier-repair serum and crème duo that calms redness, restores moisture, and strengthens sensitive or post-procedure skin.

$395.00

Unit price: per

4.9

Rated 4.9 out of 5 stars

29 Reviews

Quantity

Earn points for this product!

Shipping calculated at checkout.

The Epicutis Luxury Skincare Set pairs two of Epicutis's most targeted treatments, Lipid Serum and Hyvia Crème, into a complete routine built around barrier repair, deep hydration, and lasting skin comfort. Both products are fragrance-free and formulated with a focused set of bioactive ingredients that address sensitivity, dryness, and environmental stress at the skin level.
Key Benefits
Barrier Repair from the Inside Out Ceramide NP in Hyvia Crème replenishes one of the skin's most critical structural lipids, helping to restore the barrier that keeps moisture in and irritants out.
Sustained, Multi-Layer Hydration Sodium hyaluronate in the Lipid Serum draws water into the skin, while glycerin across both formulas keeps that moisture locked in throughout the day and night.
Targeted Calming for Reactive Skin Disodium tetramethylhexadecenyl succinoylcysteine (the Lipid Serum's key active) and Spilanthes acmella flower extract in Hyvia Crème work together to visibly reduce redness and calm inflammation at the source.
Antioxidant Defense Against Environmental Stress Tocopherol and ferulic acid in Hyvia Crème neutralize free radicals from pollution, blue light, and UV exposure before they can break down the skin's structural proteins.
Nourishing Lipid Replenishment Shea butter, meadowfoam seed oil, chia seed oil, evening primrose seed extract, and phytosterols in Hyvia Crème deliver a rich blend of fatty acids and plant sterols that soften, condition, and reinforce the skin's lipid matrix.
Lipid Serum (1 oz): A lightweight, fast-absorbing serum with therapeutic levels of patented TSC, a potent anti-inflammatory lipid that calms irritation, locks in hydration, and defends against collagen breakdown at the cellular level.

Hyvia® Crème (1.7 oz): A rich, velvety moisturizer powered by HYVIA® (chia seed extract), DSD, and botanical antioxidants to deliver deep hydration, protect against environmental aggressors, and leave skin dewy, plump, and glowing.
If your skin is persistently dry, reactive, or easily irritated, this set gives you a complete morning and evening routine built around restoring what your barrier is missing. Both products are fragrance-free and formulated without unnecessary irritants, making them well-suited for skin that tends to flare with conventional moisturizers.
This set is especially effective during post-procedure recovery, including after chemical peels, laser treatments, microneedling, or any procedure that temporarily compromises the barrier. It is also a strong match for anyone managing chronic dryness, redness, or sensitivity related to seasonal changes or environmental exposure.
If you are looking for a clinically focused hydration and barrier repair duo without heavy perfumes or actives that could overstimulate sensitive skin, the Epicutis Luxury Skincare Set delivers exactly that.
For skin that is actively recovering from a procedure or going through a particularly reactive period, press the Lipid Serum in with your palms rather than rubbing. This technique minimizes friction on compromised skin while still delivering the full benefit of the actives. Once your skin has stabilized, you can go back to a light massage application with Hyvia Crème.
Prepare: Cleanse skin thoroughly and pat dry before applying.
Apply (Step 1): Dispense 1-2 pumps of Lipid Serum and press gently into the face, neck, and décolleté.
Apply (Step 2): Follow immediately with a pea-sized amount of Hyvia Crème, massaging in gentle upward strokes until fully absorbed.
Frequency: Use both products morning and night for best results.
Key Ingredients

TSC (Disodium Tetramethylhexadecenyl Succinoyl Cysteine): A breakthrough super-lipid that strengthens the skin’s natural barrier while providing powerful protection against environmental stressors like UV rays and pollution.
Hyvia: A next-generation moisturizing ingredient derived from organic chia seed oil that delivers concentrated omega-3 and omega-6 fatty acids to deeply hydrate, calm inflammation, and visibly reduce fine lines and signs of aging at the cellular level.
DSD (Disodium S-phytyl Diglycoloylcysteine): A powerful antioxidant that protects against external stressors like uv damage and pollution. The perfect vitamin c alternative!
Phytosterols: Plant-derived lipids that mimic the function of cholesterol in the skin, helping to strengthen the skin barrier, reduce inflammation, and lock in moisture.
Shea Butter: Softens, seals in moisture, and helps protect against environmental damage.

Lipid Serum: Water, Propanediol, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Sodium Phytate, Citric Acid

Hyvia Creme: Water, Caprylic/ Capric Triglyceride, Propanediol, Glycerin, Butyrospermum Parkii (Shea) Butter, Pentylene Glycol, Limnanthes Alba Meadowfoam Seed Oil, Glyceryl Stearate SE, Stearyl Alcohol, Steareth-20, Tocopherol, Salvia Hispanica Seed Oil, DSD (Disodium S-Phytyl Diglycoloylcysteine), Spilanthes Acmella Flower Extract, Ceramide NP, Isocetyl Alcohol, Cetyl Alcohol, Phytosterols, Ferulic Acid, Oenothera Biennis (Evening Primrose) Seed Extract, Butylene Glycol, Carbomer, Sodium Phytate, Potassium Hydroxide
What makes the Epicutis Luxury Skincare Set different from a standard moisturizer and serum pairing?

Both products in the Epicutis Luxury Skincare Set are built specifically around barrier biology rather than surface-level hydration. The Lipid Serum uses disodium tetramethylhexadecenyl succinoylcysteine alongside sodium hyaluronate to hydrate and calm at a functional level, while Hyvia Crème delivers ceramide NP, phytosterols, and a blend of plant lipids that actually replenish what a compromised barrier is missing. Together they address hydration, inflammation, and structural repair in a single routine.

Can the Epicutis Luxury Skincare Set be used immediately after a facial treatment or procedure?

Yes. Both products in the Epicutis Luxury Skincare Set are fragrance-free and formulated without known sensitizers, making them appropriate for post-procedure skin that is temporarily more vulnerable. The Lipid Serum's calming active and Hyvia Crème's ceramide and lipid blend support recovery without risking additional irritation. Many estheticians recommend this pairing specifically for the post-procedure window.

What does disodium tetramethylhexadecenyl succinoylcysteine do in the Epicutis Lipid Serum?

Disodium tetramethylhexadecenyl succinoylcysteine, also referred to as DSD in the Hyvia Crème formulation and listed under a related name in the serum, is a lipid-amino acid conjugate that integrates into the skin's own lipid architecture. It helps reduce inflammation and redness while reinforcing the barrier from within. This is the primary active that distinguishes the Lipid Serum from a standard hydrating serum.

What role do ferulic acid and tocopherol play in Epicutis Hyvia Crème?

Ferulic acid and tocopherol are both antioxidants, and they work more effectively when combined. Tocopherol (vitamin E) neutralizes free radicals generated by UV exposure and pollution, while ferulic acid stabilizes that protection and extends its effectiveness. In Hyvia Crème, this pairing adds an environmental defense layer to the core hydration and barrier work the formula is built around.

Is the Epicutis Luxury Skincare Set appropriate for oily or acne-prone skin?

The set is formulated primarily for dry, sensitive, and barrier-compromised skin types and may feel richer than what oily or acne-prone skin typically tolerates. That said, a compromised barrier can be present in any skin type, including oily skin. If you are unsure whether this set is the right fit for your skin, a free skincare consultation with one of our estheticians is the best way to find out.

What is ceramide NP and why does it matter in Epicutis Hyvia Crème?

Ceramide NP is one of the primary ceramides found naturally in healthy skin, where it plays a central role in holding the barrier together and preventing transepidermal water loss. When the barrier is damaged, ceramide levels drop and skin becomes more reactive, dry, and sensitive. Including ceramide NP in Hyvia Crème helps restore that lipid layer directly, supporting long-term barrier resilience rather than just temporary hydration.

Can the Epicutis Luxury Skincare Set be used alongside other active treatments like retinoids or exfoliating acids?

Yes, and it is actually well-suited to that role. Both products focus on hydration and barrier support rather than exfoliation or cell turnover, which means they complement rather than compete with retinoids, glycolic acid, or other actives. Using this set alongside a retinoid or acid treatment can help buffer sensitivity and keep the barrier strong enough to tolerate those actives over time.

Why buy the Epicutis Luxury Skincare Set from Art of Skin Care?

Art of Skin Care is an authorized retailer of Epicutis, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if the Epicutis Luxury Skincare Set is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.

Learn More

The Epicutis Luxury Skincare Set pairs two of Epicutis's most targeted treatments, Lipid Serum and Hyvia Crème, into a complete routine built around barrier repair, deep hydration, and lasting skin comfort. Both products are fragrance-free and formulated with a focused set of bioactive ingredients that address sensitivity, dryness, and environmental stress at the skin level.

Key Benefits

Barrier Repair from the Inside Out Ceramide NP in Hyvia Crème replenishes one of the skin's most critical structural lipids, helping to restore the barrier that keeps moisture in and irritants out.

Sustained, Multi-Layer Hydration Sodium hyaluronate in the Lipid Serum draws water into the skin, while glycerin across both formulas keeps that moisture locked in throughout the day and night.

Targeted Calming for Reactive Skin Disodium tetramethylhexadecenyl succinoylcysteine (the Lipid Serum's key active) and Spilanthes acmella flower extract in Hyvia Crème work together to visibly reduce redness and calm inflammation at the source.

Antioxidant Defense Against Environmental Stress Tocopherol and ferulic acid in Hyvia Crème neutralize free radicals from pollution, blue light, and UV exposure before they can break down the skin's structural proteins.

Nourishing Lipid Replenishment Shea butter, meadowfoam seed oil, chia seed oil, evening primrose seed extract, and phytosterols in Hyvia Crème deliver a rich blend of fatty acids and plant sterols that soften, condition, and reinforce the skin's lipid matrix.

What's Included

Who it's For

Esthetician Recommendations

How to Use

Ingredients

Frequently Asked Questions

What makes the Epicutis Luxury Skincare Set different from a standard moisturizer and serum pairing?

Both products in the Epicutis Luxury Skincare Set are built specifically around barrier biology rather than surface-level hydration. The Lipid Serum uses disodium tetramethylhexadecenyl succinoylcysteine alongside sodium hyaluronate to hydrate and calm at a functional level, while Hyvia Crème delivers ceramide NP, phytosterols, and a blend of plant lipids that actually replenish what a compromised barrier is missing. Together they address hydration, inflammation, and structural repair in a single routine.

Can the Epicutis Luxury Skincare Set be used immediately after a facial treatment or procedure?

Yes. Both products in the Epicutis Luxury Skincare Set are fragrance-free and formulated without known sensitizers, making them appropriate for post-procedure skin that is temporarily more vulnerable. The Lipid Serum's calming active and Hyvia Crème's ceramide and lipid blend support recovery without risking additional irritation. Many estheticians recommend this pairing specifically for the post-procedure window.

What does disodium tetramethylhexadecenyl succinoylcysteine do in the Epicutis Lipid Serum?

Disodium tetramethylhexadecenyl succinoylcysteine, also referred to as DSD in the Hyvia Crème formulation and listed under a related name in the serum, is a lipid-amino acid conjugate that integrates into the skin's own lipid architecture. It helps reduce inflammation and redness while reinforcing the barrier from within. This is the primary active that distinguishes the Lipid Serum from a standard hydrating serum.

What role do ferulic acid and tocopherol play in Epicutis Hyvia Crème?

Ferulic acid and tocopherol are both antioxidants, and they work more effectively when combined. Tocopherol (vitamin E) neutralizes free radicals generated by UV exposure and pollution, while ferulic acid stabilizes that protection and extends its effectiveness. In Hyvia Crème, this pairing adds an environmental defense layer to the core hydration and barrier work the formula is built around.

Is the Epicutis Luxury Skincare Set appropriate for oily or acne-prone skin?

The set is formulated primarily for dry, sensitive, and barrier-compromised skin types and may feel richer than what oily or acne-prone skin typically tolerates. That said, a compromised barrier can be present in any skin type, including oily skin. If you are unsure whether this set is the right fit for your skin, a free skincare consultation with one of our estheticians is the best way to find out.

What is ceramide NP and why does it matter in Epicutis Hyvia Crème?

Ceramide NP is one of the primary ceramides found naturally in healthy skin, where it plays a central role in holding the barrier together and preventing transepidermal water loss. When the barrier is damaged, ceramide levels drop and skin becomes more reactive, dry, and sensitive. Including ceramide NP in Hyvia Crème helps restore that lipid layer directly, supporting long-term barrier resilience rather than just temporary hydration.

Can the Epicutis Luxury Skincare Set be used alongside other active treatments like retinoids or exfoliating acids?

Yes, and it is actually well-suited to that role. Both products focus on hydration and barrier support rather than exfoliation or cell turnover, which means they complement rather than compete with retinoids, glycolic acid, or other actives. Using this set alongside a retinoid or acid treatment can help buffer sensitivity and keep the barrier strong enough to tolerate those actives over time.

Why buy the Epicutis Luxury Skincare Set from Art of Skin Care?

Art of Skin Care is an authorized retailer of Epicutis, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if the Epicutis Luxury Skincare Set is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.