FACTORFIVE Night Retinol Cream
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FACTORFIVE Night Retinol Cream is a high-performance nighttime moisturizer that pairs lipid-encapsulated retinol with human stem cell conditioned media to visibly reduce wrinkles and fine lines while you sleep. The lipid encapsulation delivers retinol deeper into the skin compared to standard formulas, so you get more visible firming and smoothing without the surface irritation that often comes with retinoids. A melon scent gives each application a fresh, pleasant finish.
Key Benefits:
Deeper Retinol Delivery for Visible Anti-Aging Results: Lipid-encapsulated retinyl linoleate penetrates further into skin than conventional retinol, helping to smooth wrinkles and fine lines more effectively at the cellular level.
Growth Factor Support for Skin Renewal: Human stem cell conditioned media supplies a concentrated blend of growth factors and cytokines that support collagen production and help restore a firmer, more lifted appearance overnight.
Multi-Peptide Firming Complex: A trio of advanced peptides, including bis (tripeptide-1) copper acetate, acetyl octapeptide-3, and palmitoyl tripeptide-37, work alongside growth factors to target visible sagging and loss of elasticity.
Skin Barrier Nourishment Without Clogging Pores: Squalane, meadowfoam seed oil, refined shea butter, and niacinamide strengthen the moisture barrier and calm the skin, keeping it hydrated through the night without contributing to breakouts.
Soothing Botanical Support: Aloe barbadensis leaf juice, green tea leaf extract, and acmella oleracea extract help reduce visible redness and provide antioxidant protection against environmental stress.
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If fine lines, wrinkles, or loss of firmness are your primary concerns and you want a retinol that works harder overnight, this cream was designed for you. The lipid-encapsulated delivery system makes it a strong option if standard retinol products have felt too surface-level or left your skin irritated without delivering real results.
Ideal for normal, dry, combination, or mature skin types looking for a nighttime treatment that combines anti-aging peptides and growth factors in a single step. The refined shea butter formulation is also suited for acne-prone skin that still needs effective wrinkle correction.
If you are new to retinol, the gradual introduction schedule lets your skin build tolerance comfortably over time.
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Shake the bottle well before every use to ensure the lipid-encapsulated retinol and growth factors are evenly distributed. Skipping this step can mean uneven potency from pump to pump, and you want every application to deliver consistent results.
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Prepare: Shake well before each use. Cleanse skin thoroughly and apply your preferred FACTORFIVE serum first. Wait 10 to 30 minutes for the serum to fully dry.
Apply: Dispense a pea-sized amount and gently smooth over face, neck, and décolleté.
Frequency: Begin by using every other night to build tolerance. Gradually increase to nightly use as your skin adjusts.
Note: Discontinue use if persistent irritation occurs.
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Key Ingredients
- Human Adipose Mesenchymal Stem Cell Conditioned Media: Collected output of adult adipose-derived stem cells, rich in growth factors, anti-inflammatory molecules, and signaling proteins that communicate directly with the skin's own repair mechanisms to support tissue regeneration and restore structural integrity at a cellular level.
- Retinyl Linoleate: A gentle, stable form of vitamin A that helps support skin renewal and a smoother, more even-looking texture over time, without the irritation often associated with stronger retinoids.
- Copper Tripeptide-1 (GHK-Cu): Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- SNAP-8 (Acetyl Octapeptide-3): A neuropeptide that relaxes wrinkles caused in expression zones such as the forehead and eye area. Reduces wrinkle depth, smoothes, and promotes an even texture.
- Acmella Oleracea Extract: Often called the "natural Botox" ingredient, it is prized for its ability to help smooth the look of fine lines by supporting a relaxed, more even skin surface.
- Buglossoides Arvense (Ahiflower) Seed Oil: Plant-based oil rich in omega fatty acids that helps nourish and replenish the skin barrier, leaving skin soft, supple, and balanced.
- Palmitoyl Tripeptide-37: A multi-benefit peptide with anti-inflammatory and antioxidant properties. Also promotes stem cell generation, wound healing, and collagen and elastin production.
Water (Aqua), Human Stem Cell Conditioned Media, Caprylic/Capric Triglyceride, C12-15 Alkyl Benzoate, Squalane, Dicaprylyl Carbonate, Euphorbia Cerifera (Candelilla) Wax, Polyhydroxystearic Acid, Aloe Barbadensis Leaf Juice, C14-22 Alcohols and C12-20 Alkyl Glucoside, Buglossoides Arvense (Ahiflower) Seed Oil, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Cetearyl Alcohol, Niacinamide, Phenoxyethanol, *Butyrospermum Parkii (Shea) Butter, Bis (Tripeptide-1) Copper Acetate, Polyacrylate Crosspolymer-6, PPG-12/SMDI Copolymer, PEG-100 Stearate, Glyceryl Stearate, Camellia Sinensis (Green Tea) Leaf Extract, Retinyl Linoleate, Polyacrylamide, Acetyl Octapeptide-3, Acmella Oleracea Extract, Fragrance, Palmitoyl Tripeptide-37, Sodium Hyaluronate, Tocopheryl, Ethylhexylglycerin, C13-14 Isoparaffin, Laureth-7
*Refined to be acne safe -
We offer free shipping on every order $50+ (just $7 flat-rate below that). Orders placed before 1pm PST Monday through Friday ship out the same day. Orders placed outside of that window are shipped the very next business day!
Changed your mind? We get it. That's why our return window is generous: 30 days even if you've opened and tried it, or a full 60 days if it's still sealed. Some exclusions apply. See our full return policy for details. -
What type of retinol is in FACTORFIVE Night Retinol Cream?
The formula contains retinyl linoleate, a retinol derivative that is lipid-encapsulated for deeper penetration into the skin. Unlike time-released retinol that slowly dissolves at the surface, lipid encapsulation carries the active further past the outer layers, which helps improve visible wrinkles and fine lines more effectively while reducing surface irritation.
What are the growth factors in FACTORFIVE Night Retinol Cream?
The growth factors come from human stem cell conditioned media, which is a concentrated collection of proteins, cytokines, and growth factors naturally produced by adult human stem cells. These signaling molecules support the skin's own collagen and elastin production, helping to visibly firm and lift over time.
Is FACTORFIVE Night Retinol Cream safe for acne-prone skin?
Yes. The shea butter in the formula has been refined to be acne-safe, and the overall formulation includes non-comedogenic emollients like squalane and meadowfoam seed oil. Niacinamide in the formula also helps balance oil production and calm breakout-prone skin.
Can I use FACTORFIVE Night Retinol Cream if I have sensitive skin?
You can, but start slowly. Begin by applying every other night and monitor how your skin responds over the first two weeks. The aloe and green tea extracts in the formula help soothe reactivity. If persistent redness or irritation develops, reduce frequency or discontinue use.
How long does a bottle of FACTORFIVE Night Retinol Cream last?
Each bottle delivers approximately 130 to 150 pumps, which typically lasts 1.5 to 2 months with nightly use of a pea-sized amount applied to the face, neck, and décolleté.
Do I need to use sunscreen with FACTORFIVE Night Retinol Cream?
Absolutely. Retinol increases your skin's sensitivity to UV exposure. Apply a broad-spectrum SPF 30 or higher every morning, even on cloudy days, to protect your results and prevent sun-induced damage while using any retinol product.
What peptides are in FACTORFIVE Night Retinol Cream?
The formula includes three targeted peptides: bis (tripeptide-1) copper acetate, which supports collagen synthesis; acetyl octapeptide-3, which helps relax the appearance of expression lines; and palmitoyl tripeptide-37, which supports skin density and firmness. Together with the growth factors, these peptides provide a multi-pathway approach to visible anti-aging.
Why buy FACTORFIVE Night Retinol Cream from Art of Skin Care?
Art of Skin Care is an authorized retailer of FACTORFIVE, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if FACTORFIVE Night Retinol Cream is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
FACTORFIVE Night Retinol Cream is a high-performance nighttime moisturizer that pairs lipid-encapsulated retinol with human stem cell conditioned media to visibly reduce wrinkles and fine lines while you sleep. The lipid encapsulation delivers retinol deeper into the skin compared to standard formulas, so you get more visible firming and smoothing without the surface irritation that often comes with retinoids. A melon scent gives each application a fresh, pleasant finish.
Key Benefits:
Deeper Retinol Delivery for Visible Anti-Aging Results: Lipid-encapsulated retinyl linoleate penetrates further into skin than conventional retinol, helping to smooth wrinkles and fine lines more effectively at the cellular level.
Growth Factor Support for Skin Renewal: Human stem cell conditioned media supplies a concentrated blend of growth factors and cytokines that support collagen production and help restore a firmer, more lifted appearance overnight.
Multi-Peptide Firming Complex: A trio of advanced peptides, including bis (tripeptide-1) copper acetate, acetyl octapeptide-3, and palmitoyl tripeptide-37, work alongside growth factors to target visible sagging and loss of elasticity.
Skin Barrier Nourishment Without Clogging Pores: Squalane, meadowfoam seed oil, refined shea butter, and niacinamide strengthen the moisture barrier and calm the skin, keeping it hydrated through the night without contributing to breakouts.
Soothing Botanical Support: Aloe barbadensis leaf juice, green tea leaf extract, and acmella oleracea extract help reduce visible redness and provide antioxidant protection against environmental stress.
If fine lines, wrinkles, or loss of firmness are your primary concerns and you want a retinol that works harder overnight, this cream was designed for you. The lipid-encapsulated delivery system makes it a strong option if standard retinol products have felt too surface-level or left your skin irritated without delivering real results.
Ideal for normal, dry, combination, or mature skin types looking for a nighttime treatment that combines anti-aging peptides and growth factors in a single step. The refined shea butter formulation is also suited for acne-prone skin that still needs effective wrinkle correction.
If you are new to retinol, the gradual introduction schedule lets your skin build tolerance comfortably over time.
Shake the bottle well before every use to ensure the lipid-encapsulated retinol and growth factors are evenly distributed. Skipping this step can mean uneven potency from pump to pump, and you want every application to deliver consistent results.
Prepare: Shake well before each use. Cleanse skin thoroughly and apply your preferred FACTORFIVE serum first. Wait 10 to 30 minutes for the serum to fully dry.
Apply: Dispense a pea-sized amount and gently smooth over face, neck, and décolleté.
Frequency: Begin by using every other night to build tolerance. Gradually increase to nightly use as your skin adjusts.
Note: Discontinue use if persistent irritation occurs.
- Human Adipose Mesenchymal Stem Cell Conditioned Media: Collected output of adult adipose-derived stem cells, rich in growth factors, anti-inflammatory molecules, and signaling proteins that communicate directly with the skin's own repair mechanisms to support tissue regeneration and restore structural integrity at a cellular level.
- Retinyl Linoleate: A gentle, stable form of vitamin A that helps support skin renewal and a smoother, more even-looking texture over time, without the irritation often associated with stronger retinoids.
- Copper Tripeptide-1 (GHK-Cu): Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- SNAP-8 (Acetyl Octapeptide-3): A neuropeptide that relaxes wrinkles caused in expression zones such as the forehead and eye area. Reduces wrinkle depth, smoothes, and promotes an even texture.
- Acmella Oleracea Extract: Often called the "natural Botox" ingredient, it is prized for its ability to help smooth the look of fine lines by supporting a relaxed, more even skin surface.
- Buglossoides Arvense (Ahiflower) Seed Oil: Plant-based oil rich in omega fatty acids that helps nourish and replenish the skin barrier, leaving skin soft, supple, and balanced.
- Palmitoyl Tripeptide-37: A multi-benefit peptide with anti-inflammatory and antioxidant properties. Also promotes stem cell generation, wound healing, and collagen and elastin production.
Water (Aqua), Human Stem Cell Conditioned Media, Caprylic/Capric Triglyceride, C12-15 Alkyl Benzoate, Squalane, Dicaprylyl Carbonate, Euphorbia Cerifera (Candelilla) Wax, Polyhydroxystearic Acid, Aloe Barbadensis Leaf Juice, C14-22 Alcohols and C12-20 Alkyl Glucoside, Buglossoides Arvense (Ahiflower) Seed Oil, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Cetearyl Alcohol, Niacinamide, Phenoxyethanol, *Butyrospermum Parkii (Shea) Butter, Bis (Tripeptide-1) Copper Acetate, Polyacrylate Crosspolymer-6, PPG-12/SMDI Copolymer, PEG-100 Stearate, Glyceryl Stearate, Camellia Sinensis (Green Tea) Leaf Extract, Retinyl Linoleate, Polyacrylamide, Acetyl Octapeptide-3, Acmella Oleracea Extract, Fragrance, Palmitoyl Tripeptide-37, Sodium Hyaluronate, Tocopheryl, Ethylhexylglycerin, C13-14 Isoparaffin, Laureth-7
*Refined to be acne safe
We offer free shipping on every order $50+ (just $7 flat-rate below that). Orders placed before 1pm PST Monday through Friday ship out the same day. Orders placed outside of that window are shipped the very next business day!
Changed your mind? We get it. That's why our return window is generous: 30 days even if you've opened and tried it, or a full 60 days if it's still sealed. Some exclusions apply. See our full return policy for details.
What type of retinol is in FACTORFIVE Night Retinol Cream?
The formula contains retinyl linoleate, a retinol derivative that is lipid-encapsulated for deeper penetration into the skin. Unlike time-released retinol that slowly dissolves at the surface, lipid encapsulation carries the active further past the outer layers, which helps improve visible wrinkles and fine lines more effectively while reducing surface irritation.
What are the growth factors in FACTORFIVE Night Retinol Cream?
The growth factors come from human stem cell conditioned media, which is a concentrated collection of proteins, cytokines, and growth factors naturally produced by adult human stem cells. These signaling molecules support the skin's own collagen and elastin production, helping to visibly firm and lift over time.
Is FACTORFIVE Night Retinol Cream safe for acne-prone skin?
Yes. The shea butter in the formula has been refined to be acne-safe, and the overall formulation includes non-comedogenic emollients like squalane and meadowfoam seed oil. Niacinamide in the formula also helps balance oil production and calm breakout-prone skin.
Can I use FACTORFIVE Night Retinol Cream if I have sensitive skin?
You can, but start slowly. Begin by applying every other night and monitor how your skin responds over the first two weeks. The aloe and green tea extracts in the formula help soothe reactivity. If persistent redness or irritation develops, reduce frequency or discontinue use.
How long does a bottle of FACTORFIVE Night Retinol Cream last?
Each bottle delivers approximately 130 to 150 pumps, which typically lasts 1.5 to 2 months with nightly use of a pea-sized amount applied to the face, neck, and décolleté.
Do I need to use sunscreen with FACTORFIVE Night Retinol Cream?
Absolutely. Retinol increases your skin's sensitivity to UV exposure. Apply a broad-spectrum SPF 30 or higher every morning, even on cloudy days, to protect your results and prevent sun-induced damage while using any retinol product.
What peptides are in FACTORFIVE Night Retinol Cream?
The formula includes three targeted peptides: bis (tripeptide-1) copper acetate, which supports collagen synthesis; acetyl octapeptide-3, which helps relax the appearance of expression lines; and palmitoyl tripeptide-37, which supports skin density and firmness. Together with the growth factors, these peptides provide a multi-pathway approach to visible anti-aging.
Why buy FACTORFIVE Night Retinol Cream from Art of Skin Care?
Art of Skin Care is an authorized retailer of FACTORFIVE, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if FACTORFIVE Night Retinol Cream is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
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FACTORFIVE Night Retinol Cream
- JTjustice t.Verified ReviewerReviewingFACTORFIVE Night Retinol CreamI recommend this productHow old are you? 30-39What is your skin type? DryWhat is your skin tone? FairWhat are your skin concerns? Blemish-prone, Pigmentation, Dryness, Sun Damage, AgeingRated 5 out of 5 stars7 minutes agoobsessed
This is seriously a little superhero in a jar. It’s super nourishing, but I didn’t find it irritating at all, which I really appreciated with a retinol product. My skin has looked noticeably firmer and just overall smoother since using it. I also love that it combines retinol with stem cell conditioned media and copper peptides. It feels like you’re getting so much in one product without having to layer a ton of different treatments.
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