Circadia Counter A.G.E. Balancing Serum 15mL 0.5 fl oz dark blue dropper bottle on light gray background

Circadia Counter A.G.E. Balancing Serum close-up texture swatch showing lightweight cream-to-serum consistency

Close-up of Circadia Counter A.G.E. Balancing Serum dropper bottle, a powerful anti-aging serum that combats glycation to preserve collagen and elastin for firmer, smoother skin

Circadia Counter A.G.E. Balancing Serum dropper bottle with key ingredients: L-Carnosine to prevent glycation, Milk Thistle Extract for antioxidant protection, Niacinamide Vitamin B3 to improve tone, and D-Ribose for cell renewal

Smiling woman with radiant skin showing Circadia Counter A.G.E. Balancing Serum is best for all skin types, aging, premature aging, and loss of firmness

Five-star verified customer review for Circadia Counter A.G.E. Balancing Serum praising its ingredients and effectiveness at fighting glycation

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Circadia Counter A.G.E. Balancing Serum

Name: Circadia Counter A.G.E. Balancing Serum
Brand: Circadia
SKU: CISE01521
Availability: InStock
Rating: 4.6 (13 reviews)

Circadia

A peptide and antioxidant serum that targets glycation to protect collagen, improve firmness, and visibly smooth skin texture.

4.6

Rated 4.6 out of 5 stars

13 Reviews

Size: 0.5 oz

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The Circadia Counter A.G.E. Balancing Serum is a targeted antioxidant treatment built around one of the most underaddressed drivers of premature aging: glycation. Glycation happens when excess sugars bind to collagen and elastin fibers in the skin, making them rigid and prone to breakdown over time. The result is progressive loss of firmness, rough or crepey texture, and skin that stops bouncing back. This serum is formulated to interrupt that process at the source, neutralize existing advanced glycation end products (A.G.E.s), and reinforce the structural proteins that keep skin resilient.
Key Benefits
Neutralizes Glycation Damage Carnosine and decarboxy carnosine HCL work together to bind to and deactivate advanced glycation end products before they can stiffen collagen and elastin fibers.
Supports Collagen Integrity Tripeptide-9 citrulline signals the skin to reinforce its extracellular matrix, helping maintain the structural protein network responsible for firmness and bounce.
Defends Against Oxidative Stress Leontopodium alpinum (edelweiss) flower and leaf extract delivers potent antioxidant protection, shielding skin from the environmental oxidative stress that accelerates structural breakdown.
Smooths and Refines Texture Glucosamine HCL and Pisum sativum (pea) extract work together to visibly improve rough, uneven texture associated with A.G.E. accumulation, leaving skin feeling consistently smoother.
Hydrates and Calms the Skin Barrier Sodium hyaluronate draws moisture into the skin, while panthenol soothes and helps maintain a balanced, comfortable barrier throughout treatment.
If your skin has started to feel less firm, more rough in texture, or has taken on a crepey quality that no amount of hydration seems to fix, glycation may be a factor worth addressing. The Circadia Counter A.G.E. Balancing Serum is designed for anyone whose skin is showing the early to moderate signs of structural breakdown, particularly those who want to address the root cause rather than simply mask surface concerns.
This serum is especially well suited for skin in the 30s and beyond, when cumulative glycation damage from diet, UV exposure, and natural aging begins to accumulate noticeably. It works equally well for those who are proactively building an age-prevention routine and want to protect collagen before visible damage sets in.
Because the formula relies on targeted peptides and botanical antioxidants rather than harsh exfoliants or high-concentration acids, it is appropriate for a wide range of skin types, including sensitive and inflammation-prone skin. It is fragrance-free and formulated without parabens.
For best results with texture and firmness, use this serum consistently for at least eight weeks. Glycation-related changes develop gradually, and the actives in this formula, particularly carnosine and tripeptide-9 citrulline, work cumulatively. Patience with the routine is what separates noticeable improvement from none at all.
Cleanse and Tone Complete your cleansing and toning steps before applying.
Apply Dispense a few drops and press evenly into the face, neck, and chest.
Layer Follow with your moisturizer to seal in the treatment.
Frequency Use morning and evening. In the morning, always finish with a broad-spectrum SPF.
Key Ingredients

DermalRx® LuShield™ (Osmanthus Fragrans Flower): Detoxifies the skin from glycating agents and oxidants, protects against glycation-induced inflammation, and prevents cell damage from A.G.E.s and excess sugar.
Tripeptide-9 Citrulline: Contains chelating properties, binding to metal ions, thus protecting DNA from damage.
Edelweiss: Defends skin from environmental stressors and free radical damage.
Plantago Lanceolata Leaf Extract: Botanical that reduces irritation and inflammation and boosts the natural healing process.
Carnosine: An anti-glycation antioxidant that helps protect and maintain collagen integrity.

Aqua/Water, Citric Acid, Glycerin, Panthenol, Pentylene Glycol, Sodium Hyaluronate, Propanediol, Glucosamine HCL, Osmanthus Fragrans Flower Extract, Lysine HCL, Lecithin, Pisum Sativum Extract, Bambusa Vulgaris Leaf/Stem Extract, Carnosine, Leontopodium Alpinum Flower/Leaf Extract, Sodium Metabisulfite, Decarboxy Carnosine HCL, Butylene Glycol, Sodium Hydroxide, Potassium Sorbate, Sodium Benzoate, Tripeptide-9 Citrulline, Tetrasodium EDTA, Phenoxyethanol, Caprylyl Glycol, Hexylene Glycol.
We offer free shipping on every order $50+ (just $7 flat-rate below that). Orders placed before 1pm PST Monday through Friday ship out the same day. Orders placed outside of that window are shipped the very next day!

Changed your mind? We get it. That's why our return window is generous: 30 days even if you've opened and tried it, or a full 60 days if it's still sealed. Some exclusions apply. See our full return policy for details.
What is glycation, and why does the Circadia Counter A.G.E. Balancing Serum target it?

Glycation is a process in which sugar molecules bond to collagen and elastin fibers, forming compounds called advanced glycation end products, or A.G.E.s. Over time, A.G.E.s make those fibers stiff and fragile, contributing to loss of firmness, rough texture, and crepey skin. The Circadia Counter A.G.E. Balancing Serum is formulated with ingredients like carnosine and decarboxy carnosine HCL that specifically target this process, helping to neutralize existing A.G.E.s and slow the formation of new ones.

How does carnosine in the Circadia Counter A.G.E. Balancing Serum work?

Carnosine is a naturally occurring dipeptide with a well-documented ability to act as an anti-glycation agent. It works by binding to the carbonyl groups that initiate A.G.E. formation, essentially intercepting the reaction before it can damage collagen and elastin. The formula pairs carnosine with decarboxy carnosine HCL, a more stable derivative that reinforces the same protective effect and improves penetration.

What does tripeptide-9 citrulline do in the Circadia Counter A.G.E. Balancing Serum?

Tripeptide-9 citrulline is a signaling peptide that communicates with fibroblasts, the cells responsible for producing collagen. By stimulating the extracellular matrix, it helps support the structural protein network that gives skin its firmness and resilience. In a formula designed to prevent collagen breakdown from glycation, this peptide complements the anti-glycation actives by encouraging the skin to maintain the collagen it already has.

Is the Circadia Counter A.G.E. Balancing Serum suitable for sensitive skin?

Yes. The formula does not rely on chemical exfoliants, retinoids, or high-concentration acids, making it appropriate for sensitive and reactive skin types. Key soothing ingredients include panthenol and sodium hyaluronate, which help maintain barrier comfort throughout use. The serum is also fragrance-free and formulated without parabens.

How long does it take to see results from the Circadia Counter A.G.E. Balancing Serum?

Because glycation damage accumulates gradually, reversing its visible effects also takes time. Most users begin to notice improvements in skin texture and resilience after eight to twelve weeks of consistent twice-daily use. The anti-glycation and peptide actives in this formula are cumulative, meaning results continue to build the longer the routine is maintained.

Can the Circadia Counter A.G.E. Balancing Serum be used morning and evening?

Yes, this serum is formulated for twice-daily use. Apply it after cleansing and toning, then follow with a moisturizer. When used in the morning, always layer a broad-spectrum SPF on top, since UV exposure accelerates both glycation and oxidative stress, which can undermine the benefits of the treatment.

What role does edelweiss extract play in the Circadia Counter A.G.E. Balancing Serum?

Leontopodium alpinum, commonly known as edelweiss, is included for its high concentration of natural antioxidants, particularly leontopodic acids. It provides environmental defense against the free radical damage that compounds glycation-related skin aging. Because oxidative stress and glycation often work together to degrade collagen, an antioxidant component like edelweiss extract strengthens the overall anti-aging effect of the formula.

Why buy Circadia Counter A.G.E. Balancing Serum from Art of Skin Care?

Art of Skin Care is an authorized retailer of Circadia, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if Circadia Counter A.G.E. Balancing Serum is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.

Learn More

The Circadia Counter A.G.E. Balancing Serum is a targeted antioxidant treatment built around one of the most underaddressed drivers of premature aging: glycation. Glycation happens when excess sugars bind to collagen and elastin fibers in the skin, making them rigid and prone to breakdown over time. The result is progressive loss of firmness, rough or crepey texture, and skin that stops bouncing back. This serum is formulated to interrupt that process at the source, neutralize existing advanced glycation end products (A.G.E.s), and reinforce the structural proteins that keep skin resilient.

Key Benefits

Neutralizes Glycation Damage Carnosine and decarboxy carnosine HCL work together to bind to and deactivate advanced glycation end products before they can stiffen collagen and elastin fibers.

Supports Collagen Integrity Tripeptide-9 citrulline signals the skin to reinforce its extracellular matrix, helping maintain the structural protein network responsible for firmness and bounce.

Defends Against Oxidative Stress Leontopodium alpinum (edelweiss) flower and leaf extract delivers potent antioxidant protection, shielding skin from the environmental oxidative stress that accelerates structural breakdown.

Smooths and Refines Texture Glucosamine HCL and Pisum sativum (pea) extract work together to visibly improve rough, uneven texture associated with A.G.E. accumulation, leaving skin feeling consistently smoother.

Hydrates and Calms the Skin Barrier Sodium hyaluronate draws moisture into the skin, while panthenol soothes and helps maintain a balanced, comfortable barrier throughout treatment.

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Frequently Asked Questions

What is glycation, and why does the Circadia Counter A.G.E. Balancing Serum target it?

Glycation is a process in which sugar molecules bond to collagen and elastin fibers, forming compounds called advanced glycation end products, or A.G.E.s. Over time, A.G.E.s make those fibers stiff and fragile, contributing to loss of firmness, rough texture, and crepey skin. The Circadia Counter A.G.E. Balancing Serum is formulated with ingredients like carnosine and decarboxy carnosine HCL that specifically target this process, helping to neutralize existing A.G.E.s and slow the formation of new ones.

How does carnosine in the Circadia Counter A.G.E. Balancing Serum work?

Carnosine is a naturally occurring dipeptide with a well-documented ability to act as an anti-glycation agent. It works by binding to the carbonyl groups that initiate A.G.E. formation, essentially intercepting the reaction before it can damage collagen and elastin. The formula pairs carnosine with decarboxy carnosine HCL, a more stable derivative that reinforces the same protective effect and improves penetration.

What does tripeptide-9 citrulline do in the Circadia Counter A.G.E. Balancing Serum?

Tripeptide-9 citrulline is a signaling peptide that communicates with fibroblasts, the cells responsible for producing collagen. By stimulating the extracellular matrix, it helps support the structural protein network that gives skin its firmness and resilience. In a formula designed to prevent collagen breakdown from glycation, this peptide complements the anti-glycation actives by encouraging the skin to maintain the collagen it already has.

Is the Circadia Counter A.G.E. Balancing Serum suitable for sensitive skin?

Yes. The formula does not rely on chemical exfoliants, retinoids, or high-concentration acids, making it appropriate for sensitive and reactive skin types. Key soothing ingredients include panthenol and sodium hyaluronate, which help maintain barrier comfort throughout use. The serum is also fragrance-free and formulated without parabens.

How long does it take to see results from the Circadia Counter A.G.E. Balancing Serum?

Because glycation damage accumulates gradually, reversing its visible effects also takes time. Most users begin to notice improvements in skin texture and resilience after eight to twelve weeks of consistent twice-daily use. The anti-glycation and peptide actives in this formula are cumulative, meaning results continue to build the longer the routine is maintained.

Can the Circadia Counter A.G.E. Balancing Serum be used morning and evening?

Yes, this serum is formulated for twice-daily use. Apply it after cleansing and toning, then follow with a moisturizer. When used in the morning, always layer a broad-spectrum SPF on top, since UV exposure accelerates both glycation and oxidative stress, which can undermine the benefits of the treatment.

What role does edelweiss extract play in the Circadia Counter A.G.E. Balancing Serum?

Leontopodium alpinum, commonly known as edelweiss, is included for its high concentration of natural antioxidants, particularly leontopodic acids. It provides environmental defense against the free radical damage that compounds glycation-related skin aging. Because oxidative stress and glycation often work together to degrade collagen, an antioxidant component like edelweiss extract strengthens the overall anti-aging effect of the formula.

Why buy Circadia Counter A.G.E. Balancing Serum from Art of Skin Care?

Art of Skin Care is an authorized retailer of Circadia, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if Circadia Counter A.G.E. Balancing Serum is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.