PDRN stands for polydeoxyribonucleotide, a regenerative active derived from salmon DNA. In the Dr. esthé Rejuvenating PDRN Ampoule, it appears as sodium DNA, which supports the skin's natural repair process and helps reinforce a compromised barrier. It is commonly used in professional skin recovery protocols and is particularly beneficial for sensitized, post-procedure, or chronically dry skin.

The formula is centered around skin repair and hydration rather than active exfoliation, making it a good fit for many sensitive skin types. However, the Dr. esthé Rejuvenating PDRN Ampoule does contain a jasmine fragrance and linalool, which can be irritating for those with fragrance sensitivities. If your skin reacts to scented products, we recommend a patch test or reaching out for a personalized recommendation before purchasing.

Propolis extract is a natural antioxidant derived from bees that helps protect skin from environmental stressors that contribute to dullness and uneven tone. In the Dr. esthé Rejuvenating PDRN Ampoule, it complements the barrier-repairing work of sodium DNA by supporting skin defense alongside the recovery process.

Yes, the Dr. esthé Rejuvenating PDRN Ampoule is designed for twice-daily use. Apply it after cleansing and toning, then follow with a moisturizer. In the morning, always finish your routine with a broad-spectrum sunscreen to protect the skin you are working to repair.

Most hydrating serums focus on delivering water-binding ingredients like hyaluronic acid without targeting the underlying repair process. The Dr. esthé Rejuvenating PDRN Ampoule goes a step further by including sodium DNA to support tissue regeneration and barrier reinforcement, making it better suited to skin that is damaged or struggling to recover, not just skin that needs moisture.

Apply the Dr. esthé Rejuvenating PDRN Ampoule after your toner or essence and before your moisturizer. Its milky texture absorbs well and creates an ideal base for a cream or barrier-focused moisturizer to seal everything in. In the evening, layering it under a richer occlusive product helps maximize the overnight repair benefits.

Sodium DNA is a common ingredient in post-procedure care due to its tissue-regenerating properties, and many estheticians recommend PDRN formulas during skin recovery phases. That said, if you are recovering from a specific treatment, the timing and appropriateness of any new product depends on your individual situation. Reach out to our team for personalized guidance through a free skincare consultation.

Art of Skin Care is an authorized retailer of Dr. esthé, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if Dr. esthé Rejuvenating PDRN Ampoule is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.