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Epicutis Lipid Serum

Epicutis Lipid Serum is a barrier repair serum built around a patented bioactive lipid called TSC (disodium tetramethylhexadecenyl succinoyl cysteine), a molecule that mimics the skin's own barrier-building blocks to calm inflammation, defend against collagen loss, and restore long-term resilience. With only eight total ingredients, this minimalist formula delivers immediate relief to dry, inflamed, or post-procedure skin while strengthening the barrier over time so skin can better protect itself. The formula is completely fragrance-free, making it appropriate even for the most reactive skin.

Key Benefits

Calms Inflammation and Visible Redness TSC works at the cellular level to quiet inflammatory pathways, reducing redness and reactivity from rosacea, sensitized skin, or post-procedure recovery.

Restores and Reinforces the Skin Barrier Propanediol, pentylene glycol, and glycerin work alongside TSC to replenish the lipid matrix your barrier depends on, helping skin hold onto moisture and resist environmental triggers.

Protects Against Collagen Breakdown TSC shields collagen from degradation caused by UV exposure and pollution, providing anti-aging defense without the irritation of traditional actives like retinoids or acids.

Delivers Lightweight, Lasting Hydration Sodium hyaluronate draws and binds water into the skin, while glycerin and pentylene glycol lock it in, keeping skin comfortable and hydrated without any heaviness or residue.

Minimalist, Sensitivity-Safe Formula Just eight ingredients total, no fragrance, no dyes, no unnecessary additives. This intentional simplicity makes it one of the safest serums available for reactive, compromised, or post-treatment skin.

Acne Safe

Epicutis Lipid Serum

A lightweight, fragrance-free barrier repair serum that calms redness, deeply hydrates, and protects against collagen loss for sensitive skin.
4.8
Rated 4.8 out of 5 stars
15 Reviews
Regular price $250.00
Unit price
per 
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Primary Concerns:

  • Compromised Barrier
  • Inflammation
  • Redness/Rosacea
  • Dehydration
Lotion bottle icons

Best For:

  • Dry
  • Normal
  • Oily
  • Combination
  • Sensitive

Epicutis Lipid Serum

Epicutis Lipid Serum is a barrier repair serum built around a patented bioactive lipid called TSC (disodium tetramethylhexadecenyl succinoyl cysteine), a molecule that mimics the skin's own barrier-building blocks to calm inflammation, defend against collagen loss, and restore long-term resilience. With only eight total ingredients, this minimalist formula delivers immediate relief to dry, inflamed, or post-procedure skin while strengthening the barrier over time so skin can better protect itself. The formula is completely fragrance-free, making it appropriate even for the most reactive skin.

Key Benefits

Calms Inflammation and Visible Redness TSC works at the cellular level to quiet inflammatory pathways, reducing redness and reactivity from rosacea, sensitized skin, or post-procedure recovery.

Restores and Reinforces the Skin Barrier Propanediol, pentylene glycol, and glycerin work alongside TSC to replenish the lipid matrix your barrier depends on, helping skin hold onto moisture and resist environmental triggers.

Protects Against Collagen Breakdown TSC shields collagen from degradation caused by UV exposure and pollution, providing anti-aging defense without the irritation of traditional actives like retinoids or acids.

Delivers Lightweight, Lasting Hydration Sodium hyaluronate draws and binds water into the skin, while glycerin and pentylene glycol lock it in, keeping skin comfortable and hydrated without any heaviness or residue.

Minimalist, Sensitivity-Safe Formula Just eight ingredients total, no fragrance, no dyes, no unnecessary additives. This intentional simplicity makes it one of the safest serums available for reactive, compromised, or post-treatment skin.

Essential Additions

Streamlined solutions for maximum results

Smiling woman in white robe holding Epicutis Lipid Serum dropper with 5-star review: "gentle, hydrating, reduces inflammation" – Nichole S.
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4.8
Rated 4.8 out of 5 stars
Based on 15 reviews
Total 5 star reviews: 13 Total 4 star reviews: 1 Total 3 star reviews: 1 Total 2 star reviews: 0 Total 1 star reviews: 0
15 reviews
  • KG
    Kristy G.
    Verified Buyer
    Reviewing
    Epicutis Lipid Serum
    I recommend this product
    How old are you? 40-49
    What is your skin type? Combination
    What is your skin tone? Fair
    What are your skin concerns? Ageing, Blemish-prone, Pigmentation, Wrinkles
    Rated 5 out of 5 stars
    2 weeks ago
    Run, Don’t Walk to Buy This

    I am a medical esthetician and have access to some hyped “medical grade” skincare. But N O T H I N G competes with this serum. It feels luxurious, it hydrates your skin all to hell, and it makes you G L O W. My spa doesn’t retail this and I am more than happy to pay full price for it. Be mindful about dispensing it as a little goes a long way and this product is too precious to waste. A drop for your face, a drop for your neck and décolleté. I think Epicutis is the most elegant skincare line out there.

  • AB
    Aja B.
    Verified Buyer
    Reviewing
    Epicutis Lipid Serum
    I recommend this product
    What is your skin tone? Dark
    What are your skin concerns? Ageing, Blemish-prone, Pigmentation
    How old are you? 40-49
    What is your skin type? Combination
    Rated 4 out of 5 stars
    1 month ago
    Nice and Hydrating

    The serum is lightweight and hydrating. I use it daily usually in the morning. I will use it a night if my skin is feeling dry and sensitive. My skin is softer and brighter since I started using it.

  • MC
    Magdalena C.
    Verified Buyer
    Reviewing
    Epicutis Lipid Serum
    I recommend this product
    How old are you? 40-49
    What is your skin type? Combination
    What is your skin tone? Fair
    What are your skin concerns? Ageing, Blemish-prone, Acne
    Rated 5 out of 5 stars
    2 months ago
    Love it!

    Love this serum… calms and hydrates the skin leaving it glowing and refreshed.

  • LC
    Loura C.
    Verified Buyer
    Reviewing
    Epicutis Lipid Serum
    I recommend this product
    How old are you? 40-49
    What is your skin type? Normal
    What is your skin tone? Medium
    What are your skin concerns? Ageing, Sensitivity, Wrinkles, Sun Damage, Redness
    Rated 5 out of 5 stars
    2 months ago
    Liquid Gold

    This was a game changer in my routine. A little goes a long way and after seeing results by using it only at night, I added to my morning routine as well. My skin looks and feels so hydrated and dewy.

  • AW
    Amanda W.
    Verified Buyer
    Reviewing
    Epicutis Lipid Serum
    I recommend this product
    How old are you? 30-39
    What is your skin type? Combination
    What is your skin tone? Fair
    What are your skin concerns? Redness, Ageing, Blemish-prone
    Rated 5 out of 5 stars
    2 months ago
    Love

    Good for my rosacea