iS Clinical C Eye Serum Advance+
iS Clinical C Eye Serum Advance+ is a targeted, clinical-strength eye serum that brings together pure ascorbic acid, sodium hyaluronate, and tripeptide-1 to visibly reduce fine lines, dark circles, and puffiness while defending the delicate eye area against environmental damage. iS Clinical is known for formulating with pharmaceutical-grade actives, and this serum reflects that commitment with a clean, lightweight base that absorbs quickly and layers seamlessly under makeup. It is fragrance-free, making it a comfortable daily option even for those with reactive skin.
Key Benefits
Brightens dark circles and evens tone Ascorbic acid, the purest and most potent form of vitamin C, targets discoloration beneath the eyes and works to create a more uniform, rested appearance over time.
Reduces puffiness and soothes the under-eye area Zinc sulfate helps decongest and calm the under-eye area, while polyporus umbellatus (mushroom) extract provides visible soothing support to tired, stressed skin.
Smooths fine lines and supports firmness Sodium hyaluronate draws moisture into the skin to plump the appearance of fine lines, and tripeptide-1 helps reinforce the skin's natural support structure for longer-term resilience.
Delivers meaningful antioxidant protection Ascorbic acid paired with bioflavonoids works to neutralize free radicals generated by UV exposure and daily environmental stress, helping slow the visible signs of premature aging around the eyes.
Hydrates without heaviness or migration Sodium hyaluronate delivers weightless, deep hydration that sits comfortably on the delicate eye area without migrating onto the eyelid or contributing to puffiness.
If fine lines, crepiness, dark circles, or persistent puffiness around your eyes are your primary concerns, this serum addresses each of them in one focused, twice-daily step. It works particularly well for anyone who spends time outdoors, deals with screen fatigue, or notices that the eye area tends to look tired regardless of how much sleep they get. The antioxidant and brightening actives work together to both repair existing damage and defend against further environmental aging.
The lightweight, fast-absorbing formula suits all skin types, including sensitive and acne-prone skin that cannot tolerate richer eye creams. It will not cause milia, does not feel heavy, and layers cleanly under concealer without pilling. If you have been looking for a clinical-strength vitamin C eye treatment that fits easily into both your morning and evening routines, this is a strong fit.
Because iS Clinical C Eye Serum Advance+ contains ascorbic acid at a clinical concentration and pH, it is especially effective at addressing visible sun damage around the eyes, including brown spots and crepey texture that build up over years of UV exposure. If you use it consistently in the morning before SPF, you are both treating existing damage and creating an additional antioxidant barrier against the environmental triggers that cause it.
Prepare: Cleanse and tone, then allow the eye area to dry completely before applying.
Apply: Dispense 1 to 2 drops into the palm of your hand, then gently pat around the orbital bone using your ring finger. Avoid the eyelid and inner corners.
Frequency: Use twice daily, morning and evening. In the morning, follow with your moisturizer and a broad-spectrum SPF.
- Vitamin C (L-Ascorbic Acid): A powerful antioxidant with anti-inflammatory properties, which helps reduce skin redness, brighten complexion, and even skin tone.
- Sodium Hyaluronate: The purest, salt form of hyaluronic acid, a master humectant that holds up to 1,000 times its weight in water to provide maximum hydration and plumping benefits to thirsty skin.
- Zinc Sulfate: Powerful antioxidant that provides photoprotection and healing properties.
- Copper Tripeptide-1: Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- Mushroom Extract: Rich in fatty acids, improves the ability of the skin to retain moisture and maintain a healthy skin barrier, while boosting collagen and calming inflammation.
Water/Aqua/Eau, Sodium Hyaluronate, Ascorbic Acid, Propylene Glycol, Zinc Sulfate, Dextrin, Tripeptide-1, Bioflavonoids, Polyporus Umbellatus (Mushroom) Extract, Phenoxyethanol.
Can I use iS Clinical C Eye Serum Advance+ with retinol?
Yes, the two can be used together with a simple scheduling approach. Apply iS Clinical C Eye Serum Advance+ in the morning for antioxidant protection and use retinol at night for cell turnover support. If your skin tolerates both well and you want to layer them in the same routine, apply the eye serum first, allow it to absorb fully, and then follow with retinol.
Will iS Clinical C Eye Serum Advance+ sting or irritate my eyes?
When applied correctly to the orbital bone and kept away from the eyelid and inner corners, it should not irritate. The formula has a low pH because of the ascorbic acid, so if any product migrates into the eye itself, you may feel temporary stinging. Apply sparingly with a gentle patting motion and avoid rubbing to keep it where it belongs.
How long does it take to see results with iS Clinical C Eye Serum Advance+?
Many users notice improved hydration and reduced puffiness within the first week of consistent use. Visible brightening of dark circles and smoothing of fine lines typically develop around 4 to 6 weeks, as ascorbic acid and tripeptide-1 both require sustained, twice-daily use to build their full effect.
Can I use iS Clinical C Eye Serum Advance+ under makeup?
Yes, the lightweight, fast-absorbing texture is well-suited for layering under concealer. It does not pill or cause makeup to shift. Allow about 60 seconds for the serum to fully absorb before applying your next product.
Do I need to refrigerate iS Clinical C Eye Serum Advance+ to preserve the vitamin C?
Refrigeration is not required, but storing the serum in a cool, dark place away from direct sunlight will help maintain the potency of the ascorbic acid. For best results, use the product within 6 months of opening. Refrigerating it is also a nice option in the morning if you find the cool temperature helps reduce puffiness.
Is iS Clinical C Eye Serum Advance+ safe for sensitive skin?
Yes, though a gradual introduction is recommended if your skin tends to react easily. Start with once-daily application in the evening and monitor how your skin responds. Mild tingling at first is normal with ascorbic acid and typically subsides as your skin acclimates to the formula.
Can I use iS Clinical C Eye Serum Advance+ on my entire face?
The ingredients are safe for use beyond the eye area, but this serum is formulated specifically for the delicate periorbital zone and is best used as a targeted treatment. For broader facial concerns, a full-face vitamin C serum with actives designed for wider coverage will give you more comprehensive results. Reserve iS Clinical C Eye Serum Advance+ for the eye area where its concentration and delivery are optimized.
Why buy iS Clinical C Eye Serum Advance+ from Art of Skin Care?
Art of Skin Care is an authorized retailer of iS Clinical, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if iS Clinical C Eye Serum Advance+ is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
- Unit price
- /per
Primary Concerns:
- Under Eye Circles
- Fine Lines
- Pigmentation
- Sun Damage
Best For:
- Combination
- Dry
- Normal
- Oily
- Sensitive
Adding product to your cart
iS Clinical C Eye Serum Advance+
iS Clinical C Eye Serum Advance+ is a targeted, clinical-strength eye serum that brings together pure ascorbic acid, sodium hyaluronate, and tripeptide-1 to visibly reduce fine lines, dark circles, and puffiness while defending the delicate eye area against environmental damage. iS Clinical is known for formulating with pharmaceutical-grade actives, and this serum reflects that commitment with a clean, lightweight base that absorbs quickly and layers seamlessly under makeup. It is fragrance-free, making it a comfortable daily option even for those with reactive skin.
Key Benefits
Brightens dark circles and evens tone Ascorbic acid, the purest and most potent form of vitamin C, targets discoloration beneath the eyes and works to create a more uniform, rested appearance over time.
Reduces puffiness and soothes the under-eye area Zinc sulfate helps decongest and calm the under-eye area, while polyporus umbellatus (mushroom) extract provides visible soothing support to tired, stressed skin.
Smooths fine lines and supports firmness Sodium hyaluronate draws moisture into the skin to plump the appearance of fine lines, and tripeptide-1 helps reinforce the skin's natural support structure for longer-term resilience.
Delivers meaningful antioxidant protection Ascorbic acid paired with bioflavonoids works to neutralize free radicals generated by UV exposure and daily environmental stress, helping slow the visible signs of premature aging around the eyes.
Hydrates without heaviness or migration Sodium hyaluronate delivers weightless, deep hydration that sits comfortably on the delicate eye area without migrating onto the eyelid or contributing to puffiness.
If fine lines, crepiness, dark circles, or persistent puffiness around your eyes are your primary concerns, this serum addresses each of them in one focused, twice-daily step. It works particularly well for anyone who spends time outdoors, deals with screen fatigue, or notices that the eye area tends to look tired regardless of how much sleep they get. The antioxidant and brightening actives work together to both repair existing damage and defend against further environmental aging.
The lightweight, fast-absorbing formula suits all skin types, including sensitive and acne-prone skin that cannot tolerate richer eye creams. It will not cause milia, does not feel heavy, and layers cleanly under concealer without pilling. If you have been looking for a clinical-strength vitamin C eye treatment that fits easily into both your morning and evening routines, this is a strong fit.
Because iS Clinical C Eye Serum Advance+ contains ascorbic acid at a clinical concentration and pH, it is especially effective at addressing visible sun damage around the eyes, including brown spots and crepey texture that build up over years of UV exposure. If you use it consistently in the morning before SPF, you are both treating existing damage and creating an additional antioxidant barrier against the environmental triggers that cause it.
Prepare: Cleanse and tone, then allow the eye area to dry completely before applying.
Apply: Dispense 1 to 2 drops into the palm of your hand, then gently pat around the orbital bone using your ring finger. Avoid the eyelid and inner corners.
Frequency: Use twice daily, morning and evening. In the morning, follow with your moisturizer and a broad-spectrum SPF.
- Vitamin C (L-Ascorbic Acid): A powerful antioxidant with anti-inflammatory properties, which helps reduce skin redness, brighten complexion, and even skin tone.
- Sodium Hyaluronate: The purest, salt form of hyaluronic acid, a master humectant that holds up to 1,000 times its weight in water to provide maximum hydration and plumping benefits to thirsty skin.
- Zinc Sulfate: Powerful antioxidant that provides photoprotection and healing properties.
- Copper Tripeptide-1: Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- Mushroom Extract: Rich in fatty acids, improves the ability of the skin to retain moisture and maintain a healthy skin barrier, while boosting collagen and calming inflammation.
Water/Aqua/Eau, Sodium Hyaluronate, Ascorbic Acid, Propylene Glycol, Zinc Sulfate, Dextrin, Tripeptide-1, Bioflavonoids, Polyporus Umbellatus (Mushroom) Extract, Phenoxyethanol.
Can I use iS Clinical C Eye Serum Advance+ with retinol?
Yes, the two can be used together with a simple scheduling approach. Apply iS Clinical C Eye Serum Advance+ in the morning for antioxidant protection and use retinol at night for cell turnover support. If your skin tolerates both well and you want to layer them in the same routine, apply the eye serum first, allow it to absorb fully, and then follow with retinol.
Will iS Clinical C Eye Serum Advance+ sting or irritate my eyes?
When applied correctly to the orbital bone and kept away from the eyelid and inner corners, it should not irritate. The formula has a low pH because of the ascorbic acid, so if any product migrates into the eye itself, you may feel temporary stinging. Apply sparingly with a gentle patting motion and avoid rubbing to keep it where it belongs.
How long does it take to see results with iS Clinical C Eye Serum Advance+?
Many users notice improved hydration and reduced puffiness within the first week of consistent use. Visible brightening of dark circles and smoothing of fine lines typically develop around 4 to 6 weeks, as ascorbic acid and tripeptide-1 both require sustained, twice-daily use to build their full effect.
Can I use iS Clinical C Eye Serum Advance+ under makeup?
Yes, the lightweight, fast-absorbing texture is well-suited for layering under concealer. It does not pill or cause makeup to shift. Allow about 60 seconds for the serum to fully absorb before applying your next product.
Do I need to refrigerate iS Clinical C Eye Serum Advance+ to preserve the vitamin C?
Refrigeration is not required, but storing the serum in a cool, dark place away from direct sunlight will help maintain the potency of the ascorbic acid. For best results, use the product within 6 months of opening. Refrigerating it is also a nice option in the morning if you find the cool temperature helps reduce puffiness.
Is iS Clinical C Eye Serum Advance+ safe for sensitive skin?
Yes, though a gradual introduction is recommended if your skin tends to react easily. Start with once-daily application in the evening and monitor how your skin responds. Mild tingling at first is normal with ascorbic acid and typically subsides as your skin acclimates to the formula.
Can I use iS Clinical C Eye Serum Advance+ on my entire face?
The ingredients are safe for use beyond the eye area, but this serum is formulated specifically for the delicate periorbital zone and is best used as a targeted treatment. For broader facial concerns, a full-face vitamin C serum with actives designed for wider coverage will give you more comprehensive results. Reserve iS Clinical C Eye Serum Advance+ for the eye area where its concentration and delivery are optimized.
Why buy iS Clinical C Eye Serum Advance+ from Art of Skin Care?
Art of Skin Care is an authorized retailer of iS Clinical, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if iS Clinical C Eye Serum Advance+ is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
Explore More Recommendations
iS Clinical C Eye Serum Advance+
- SBShelley B.Verified BuyerReviewingiS Clinical C Eye Serum Advance+I recommend this productHow old are you? 50-65What is your skin type? NormalWhat is your skin tone? MediumWhat are your skin concerns? AgeingRated 5 out of 5 stars2 months agoIS Clinical C Eye Serum Advance
This is my favorite eye serum
Was this helpful? - WKWanda K.Verified BuyerReviewingiS Clinical C Eye Serum Advance+I do not recommend this productHow old are you? 50-65What is your skin type? OilyWhat is your skin tone? MediumWhat are your skin concerns? Blemish-prone, Pigmentation, Ageing, Sun DamageRated 1 out of 5 stars11 months agoNot moisturizing
I love iS Clinical products but this one didn’t work for me. My eye area has become very dry and my intention was to layer this under an eye cream for extra moisture but that didn’t happen. It made my eyes feel dry.
Was this helpful?AOArt of Skin Care11 months agoHi Wanda! Thanks so much for sharing your experience! I’m sorry to hear this serum didn’t work out the way you hoped. It’s designed to brighten and soften but doesn’t add enough hydration for dryer skin types, so we always recommend layering a good eye cream over it to keep your eye area feeling comfortable.
If you’d like, our team would be happy to help you find the right combo to tackle dryness and brighten up your eyes. Just let us know—we’re here for you!
- KHKarla H.Verified BuyerReviewingiS Clinical C Eye Serum Advance+I recommend this productHow old are you? 18-29What is your skin type? DryWhat is your skin tone? MediumWhat are your skin concerns? Blemish-prone, Acne, Ageing, Pigmentation, SensitivityRated 5 out of 5 stars11 months agoMiracle serum
I’m in love a little goes a long way and helps quick
Was this helpful? - ASAllison S.Verified BuyerReviewingiS Clinical C Eye Serum Advance+I recommend this productRated 5 out of 5 stars1 year agoiS Clinical C Eye Serum Advance+
2nd time buying. Lasts a
2nd time buying. Lasts a really long time. Brand is great.
Was this helpful? - JCJulie C.Verified BuyerReviewingiS Clinical C Eye Serum Advance+How old are you? 40-49Rated 3 out of 5 stars1 year agoiS Clinical C Eye Serum Advance+
Not my favorite
I love the ingredients in this serum and it feels nourishing to my eye areas, but I haven't really seen any results. I had to get used to using the dropper as the liquid comes out really fast. I would not purchase again but I did enjoy trying it
Was this helpful?