iS Clinical Retinol+ Emulsion 1.0% is a high-potency retinol treatment from iS Clinical that delivers professional-grade anti-aging results through encapsulated delivery and a bioactive supporting cast. The formula carries a light, subtle fragrance. At its core, 1.0% encapsulated retinol works alongside Extremozyme® technology, a proprietary enzyme complex that repairs DNA damage while the retinol accelerates cellular renewal, resulting in visibly smoother, firmer skin with improved tone and texture over time.

Key Benefits

Smooths Fine Lines and Wrinkles Encapsulated retinol releases gradually into the skin, stimulating collagen production and accelerating cell turnover to visibly reduce the depth and appearance of lines and wrinkles.

Evens Tone and Refines Texture Retinol works alongside ascorbic acid and bakuchiol to fade the look of hyperpigmentation, smooth uneven texture, and restore a more consistent complexion across the face, neck, and chest.

Amplifies Retinol Efficacy Rice bran extract, tocopherol (vitamin E), and rosemary leaf extract work together as natural potency enhancers, increasing retinol's effectiveness by more than 30% without increasing the risk of irritation.

Firms and Supports Skin Structure Tripeptide-1 and shea butter help reinforce the skin's structural foundation while retinol drives collagen synthesis, improving density, resilience, and visible firmness over consistent use.

Repairs and Defends Against Environmental Aging Extremozyme® technology targets existing DNA damage caused by UV exposure and pollution, while glutathione and tocopherol neutralize free radicals to slow the progression of future visible aging.

Clinically Proven Results (after 84 days):

• 29% reduction in fine lines and wrinkles
• 19% improvement in skin hydration
• 100% improvement in breakouts (in 18% of subjects who reported subject to breakouts)
• 94% improvement in oil production/large pores (in 64% of subjects who reported history of oily skin/large pores)
• 69% improvement in pigmentation (in 46% of subjects who reported experiencing pigment irregularities)

iS Clinical Retinol+ Emulsion 1.0% is best suited for experienced retinol users who have already built a tolerance to lower concentrations and are ready to address more advanced signs of aging, including deep wrinkles, loss of firmness, uneven skin tone, and sun damage. If you've been using a 0.25% or 0.5% retinol consistently without significant irritation and feel ready to progress, this is a logical and clinically meaningful next step.

This emulsion performs best on normal to dry skin types that can handle active exfoliation. It contains fragrance, so those with highly reactive or sensitized skin should take note. If you have rosacea, eczema, or persistent sensitivity, speaking with a licensed esthetician before incorporating this concentration is a smart starting point.

If you're newer to retinoids, this is not the right entry point. Starting at a lower strength allows your skin to acclimate and reduces the likelihood of irritation, so building up gradually will serve your long-term results better than jumping straight to 1.0%.

If your skin is adjusting to this concentration, try applying iS Clinical Retinol+ Emulsion 1.0% over your moisturizer for the first several uses rather than directly on bare skin. This buffering technique slows the rate of absorption slightly, which can reduce initial dryness or flaking while still allowing your skin to acclimate to the retinol at a more comfortable pace.

Prepare: Cleanse and tone your skin in the evening, then wait until skin is completely dry before applying.

Apply: Dispense 2 to 3 pumps and smooth evenly over the face, neck, and chest. Follow with your preferred moisturizer to support hydration.

Frequency: Begin by using every 2 to 3 days for the first week, then take a full week off. Resume this cycle and gradually increase frequency as your skin builds tolerance.

Technique: Avoid layering with AHAs, BHAs, or ascorbic acid in the same routine unless directed by a skincare professional. Some initial redness, dryness, or peeling is normal and typically settles within a few weeks. Apply a broad-spectrum SPF 30 or higher every morning while using this product.