iS Clinical Super Serum Advance+
Think of this superstar as multiple serums in one. The base of vitamin C along with other potent botanical brighteners promote an overall even and glowing skin tone with superior antioxidant protection. Powerful peptides support healing and regeneration and boost collagen synthesis to visibly improve skin texture and the appearance of raised scars. Mushroom extract along with vitamin B round out the blend to calm irritation and boost moisture to improve skin barrier health for a renewed complexion.
- Minimizes the appearance of fine lines and wrinkles
- Improves the appearance of raised scars
- Brightens and evens skin tone
- Provides powerful antioxidant support
- 3.0 pH +/- 0.5
1 oz or 0.5 oz | Dropper Bottle
Formulated for all skin types looking to correct stretch marks, raised scars or the appearance of fine lines, with the ultimate brightening benefits and antioxidant protection.
Try mixing in your hand with Hydra-Cool Serum to improve hydration and absorption with a soothing effect.
After cleansing and toning, apply 3-5 drops to face, neck, and chest in morning and evening, layer with your favorite moisturizer. Be sure to follow with SPF when used in the AM.
- Vitamin C (L-Ascorbic Acid): A powerful antioxidant with anti-inflammatory properties, which helps reduce skin redness, brighten complexion, and even skin tone.
- Calcium Pantothenate (Vitamin B5): A powerful natural moisturizer, healer, and protector that rebuilds the barrier and acts as a shield against irritation.
- Arbutin: Tyrosinase inhibitor that aids in brightening dark spots, preventing hyperpigmentation, and reducing scarring.
- Mushroom Extract: Rich in fatty acids, improves the ability of the skin to retain moisture and maintain a healthy skin barrier, while boosting collagen and calming inflammation.
- Copper Tripeptide-1: Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- Centella Asiatica Extract: Helps to strengthen and repair the skin's moisture barrier with potent anti-inflammatory benefits and antioxidant protection.
Water/Aqua/Eau, Ascorbic Acid, Hyaluronic Acid, Pentylene Glycol, Arbutin, Polyporus Umbellatus (Mushroom) Extract, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine HCI, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid
Due to the all-natural botanical extracts, the color of each batch may vary slightly!
iS Clinical Super Serum Advance+ brightens, heals, and reduces scars and stretch marks for healthier-looking skin.
- Unit price
- /per

Primary Concerns:
- Dullness
- Fine Lines
- Loss of Firmness
- Pigmentation

Best For:
- Combination
- Dry
- Normal
- Oily
Adding product to your cart
iS Clinical Super Serum Advance+
Think of this superstar as multiple serums in one. The base of vitamin C along with other potent botanical brighteners promote an overall even and glowing skin tone with superior antioxidant protection. Powerful peptides support healing and regeneration and boost collagen synthesis to visibly improve skin texture and the appearance of raised scars. Mushroom extract along with vitamin B round out the blend to calm irritation and boost moisture to improve skin barrier health for a renewed complexion.
- Minimizes the appearance of fine lines and wrinkles
- Improves the appearance of raised scars
- Brightens and evens skin tone
- Provides powerful antioxidant support
- 3.0 pH +/- 0.5
1 oz or 0.5 oz | Dropper Bottle
Formulated for all skin types looking to correct stretch marks, raised scars or the appearance of fine lines, with the ultimate brightening benefits and antioxidant protection.
Try mixing in your hand with Hydra-Cool Serum to improve hydration and absorption with a soothing effect.
After cleansing and toning, apply 3-5 drops to face, neck, and chest in morning and evening, layer with your favorite moisturizer. Be sure to follow with SPF when used in the AM.
- Vitamin C (L-Ascorbic Acid): A powerful antioxidant with anti-inflammatory properties, which helps reduce skin redness, brighten complexion, and even skin tone.
- Calcium Pantothenate (Vitamin B5): A powerful natural moisturizer, healer, and protector that rebuilds the barrier and acts as a shield against irritation.
- Arbutin: Tyrosinase inhibitor that aids in brightening dark spots, preventing hyperpigmentation, and reducing scarring.
- Mushroom Extract: Rich in fatty acids, improves the ability of the skin to retain moisture and maintain a healthy skin barrier, while boosting collagen and calming inflammation.
- Copper Tripeptide-1: Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- Centella Asiatica Extract: Helps to strengthen and repair the skin's moisture barrier with potent anti-inflammatory benefits and antioxidant protection.
Water/Aqua/Eau, Ascorbic Acid, Hyaluronic Acid, Pentylene Glycol, Arbutin, Polyporus Umbellatus (Mushroom) Extract, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine HCI, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid
Due to the all-natural botanical extracts, the color of each batch may vary slightly!








Explore More Recommendations
iS Clinical Super Serum Advance+
- MVMelissa V.Verified BuyerReviewingiS Clinical Super Serum Advance+I recommend this productHow old are you? 50-65Rated 5 out of 5 stars10 months agoiS Clinical Super Serum Advance+
Potent
My skin loves all things iS Clinical! And this serum is no exception. A potent serum that absorbs quickly and penetrates deeply. Don't let the watery consistency fool you. This serum gets to work quickly improving skin tone and texture. On my first bottle and loving the results thus far.
Was this helpful? - JAJoseph A.Verified BuyerReviewingiS Clinical Super Serum Advance+I recommend this productHow old are you? 30-39Rated 5 out of 5 stars2 years agoiS Clinical Super Serum Advance+
Powerful
I layer this under my iS Clinical Pro Youth Body Complex. Really good. It is expensive but you get what you pay for.
Was this helpful? - COCathleen O.Verified BuyerReviewingiS Clinical Super Serum Advance+I recommend this productHow old are you? 50-65Rated 4 out of 5 stars2 years agoiS Clinical Super Serum Advance+
I like the IS Clinical
I like the IS Clinical Super Serum Advance+. When apply the serum dissolves in the skin. My skin feels brighter and pores seems smaller.
Was this helpful? - LSLauren S.Verified BuyerReviewingiS Clinical Super Serum Advance+I recommend this productHow old are you? 30-39What are your skin concerns? Blemish-proneRated 5 out of 5 stars2 years agoiS Clinical Super Serum Advance+
All around serum
This packs a punch helping improve skin tone, texture, and hyperpigmentation. It also works well on healing blemishes. Use it in my morning routine.
Was this helpful? - EFElise F.Verified BuyerReviewingiS Clinical Super Serum Advance+I recommend this productHow old are you? 30-39Rated 5 out of 5 stars3 years agoiS Clinical Super Serum Advance+
Like it so far!
Still on my first bottle, but I am enjoying the results so far. My skin looks brighter and more evenly toned.
Was this helpful?
Why Art of Skin Care?
At Art of Skin Care, we tailor solutions to you—no one-size-fits-all approach here. Whether tackling acne or embracing healthy aging, our expert estheticians will guide you every step of the way. More than a brand, we’re your partner in radiant, confident skin.