iS Clinical Super Serum Advance+
iS Clinical Super Serum Advance+ is a professional-grade treatment serum that combines ascorbic acid, peptides, and targeted botanicals to address some of the most persistent skin concerns: discoloration, scarring, stretch marks, uneven texture, and early signs of aging. It absorbs quickly without a heavy feel and is formulated to be effective at twice-daily use without causing irritation. Note that because this formula relies on natural botanical extracts, slight color variation between batches is completely normal and does not affect performance.
Key Benefits
Fades dark spots and discoloration Ascorbic acid and arbutin work in tandem to reduce the appearance of post-acne marks, sun damage, and uneven pigmentation across the face, neck, and chest.
Visibly improves raised scars and stretch marks Tripeptide-1 supports collagen synthesis and tissue regeneration, gradually smoothing the texture of scarring and stretch marks with consistent use.
Soothes irritation and supports barrier resilience Polyporus umbellatus (mushroom) extract and calcium pantothenate (vitamin B5) calm redness, reduce inflammation, and reinforce the skin's moisture barrier.
Protects against environmental damage Ascorbic acid neutralizes free radicals caused by UV exposure and pollution, helping to prevent oxidative stress that leads to premature aging.
Plumps and smooths the look of fine lines Hyaluronic acid and tripeptide-1 work together to hydrate and support skin structure, visibly reducing the appearance of early lines over time.
If your skin concerns span more than one category, whether that's post-acne hyperpigmentation, raised scarring, stretch marks, sun damage, or the early signs of aging, iS Clinical Super Serum Advance+ is built to address all of them within a single step. It's especially well-suited for anyone who has been frustrated by brightening serums that fade surface discoloration but do nothing to improve scar texture or skin resilience.
This serum is appropriate for all skin types, including sensitive and reactive skin. The inclusion of mushroom extract, vitamin B5, and skin-conditioning actives like glycerin and urea means the formula actively supports barrier function rather than depleting it. Even if your skin tends to respond poorly to vitamin C at lower pH levels, the soothing botanicals here help offset that reactivity for most users.
If you're targeting stretch marks on the body in addition to facial concerns, this serum translates well beyond the face. It can be applied directly to any area where you want to improve tone and texture, making it a versatile addition to both a facial and body routine.
If you're applying iS Clinical Super Serum Advance+ to areas prone to dryness or flaking, warm the drops between your palms for a few seconds before pressing the serum into the skin rather than rubbing it in. This technique improves absorption and ensures even distribution over textured or scarred areas without disturbing the surface.
Prepare: Cleanse and tone skin, then ensure it is fully dry before applying.
Apply: Dispense 3 to 5 drops into your palm and smooth evenly over the face, neck, and chest. For body use on stretch marks, apply the same amount directly to the target area.
Frequency: Use morning and evening. In the morning, follow with a broad-spectrum SPF.
- Vitamin C (L-Ascorbic Acid): A powerful antioxidant with anti-inflammatory properties, which helps reduce skin redness, brighten complexion, and even skin tone.
- Calcium Pantothenate (Vitamin B5): A powerful natural moisturizer, healer, and protector that rebuilds the barrier and acts as a shield against irritation.
- Arbutin: Tyrosinase inhibitor that aids in brightening dark spots, preventing hyperpigmentation, and reducing scarring.
- Mushroom Extract: Rich in fatty acids, improves the ability of the skin to retain moisture and maintain a healthy skin barrier, while boosting collagen and calming inflammation.
- Copper Tripeptide-1: Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- Centella Asiatica Extract: Helps to strengthen and repair the skin's moisture barrier with potent anti-inflammatory benefits and antioxidant protection.
Water/Aqua/Eau, Ascorbic Acid, Hyaluronic Acid, Pentylene Glycol, Arbutin, Polyporus Umbellatus (Mushroom) Extract, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine HCI, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid
Due to the all-natural botanical extracts, the color of each batch may vary slightly!
Can I use iS Clinical Super Serum Advance+ if I have sensitive skin?
Yes. The formula includes polyporus umbellatus (mushroom) extract and calcium pantothenate (vitamin B5), both of which actively calm irritation and strengthen the skin's barrier. While the serum works at a pH of approximately 3.0 to maximize the effectiveness of ascorbic acid, the soothing botanicals in the formula help offset potential reactivity, making it well-tolerated by most sensitive skin types with consistent use.
How long does it take to see results with iS Clinical Super Serum Advance+?
Improvements in brightness and tone are typically visible within 2 to 4 weeks of twice-daily use. For raised scars, stretch marks, and deeper texture changes, expect gradual progress over 8 to 12 weeks, as tripeptide-1 works by supporting collagen synthesis and tissue regeneration, both of which are slower biological processes. Consistency is the most important variable.
Can I layer iS Clinical Super Serum Advance+ with a retinol in my evening routine?
Yes. Apply iS Clinical Super Serum Advance+ first, allow it to absorb fully, then follow with your retinol product. Both actives can complement each other for texture and tone improvement. If you notice increased sensitivity when combining them, try alternating nights until your skin adjusts.
Will iS Clinical Super Serum Advance+ help with acne scars?
Yes, and it addresses both dimensions of acne scarring. Tripeptide-1 supports tissue repair to improve the texture of raised scars, while ascorbic acid and arbutin target the residual discoloration left behind by post-inflammatory hyperpigmentation. Used consistently twice daily, this serum works on the underlying structure and surface tone at the same time.
Does iS Clinical Super Serum Advance+ need to be refrigerated?
No refrigeration is required. Store the serum in a cool, dry location away from direct sunlight to preserve potency. Because the formula contains natural botanical extracts, slight color variation between batches is normal and has no effect on performance or efficacy.
Can I apply iS Clinical Super Serum Advance+ to my body for stretch marks?
Yes. This serum is effective on stretch marks wherever they appear on the body. Apply 3 to 5 drops directly to the affected area twice daily and press gently into the skin. Visible improvement in tone and texture develops gradually over several weeks of consistent application, driven by tripeptide-1's role in collagen synthesis and tissue regeneration.
Is iS Clinical Super Serum Advance+ safe to use in the morning?
Yes, and using it in the morning is actually beneficial because ascorbic acid actively neutralizes free radicals from UV exposure and environmental pollution throughout the day, adding a layer of antioxidant defense on top of your SPF. Just make sure to follow with a broad-spectrum sunscreen every morning, both to protect your results and because vitamin C serums can increase photosensitivity.
Why buy iS Clinical Super Serum Advance+ from Art of Skin Care?
Art of Skin Care is an authorized retailer of iS Clinical, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if iS Clinical Super Serum Advance+ is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
- Unit price
- /per
Primary Concerns:
- Dullness
- Fine Lines
- Loss of Firmness
- Pigmentation
Best For:
- Combination
- Dry
- Normal
- Oily
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iS Clinical Super Serum Advance+
iS Clinical Super Serum Advance+ is a professional-grade treatment serum that combines ascorbic acid, peptides, and targeted botanicals to address some of the most persistent skin concerns: discoloration, scarring, stretch marks, uneven texture, and early signs of aging. It absorbs quickly without a heavy feel and is formulated to be effective at twice-daily use without causing irritation. Note that because this formula relies on natural botanical extracts, slight color variation between batches is completely normal and does not affect performance.
Key Benefits
Fades dark spots and discoloration Ascorbic acid and arbutin work in tandem to reduce the appearance of post-acne marks, sun damage, and uneven pigmentation across the face, neck, and chest.
Visibly improves raised scars and stretch marks Tripeptide-1 supports collagen synthesis and tissue regeneration, gradually smoothing the texture of scarring and stretch marks with consistent use.
Soothes irritation and supports barrier resilience Polyporus umbellatus (mushroom) extract and calcium pantothenate (vitamin B5) calm redness, reduce inflammation, and reinforce the skin's moisture barrier.
Protects against environmental damage Ascorbic acid neutralizes free radicals caused by UV exposure and pollution, helping to prevent oxidative stress that leads to premature aging.
Plumps and smooths the look of fine lines Hyaluronic acid and tripeptide-1 work together to hydrate and support skin structure, visibly reducing the appearance of early lines over time.
If your skin concerns span more than one category, whether that's post-acne hyperpigmentation, raised scarring, stretch marks, sun damage, or the early signs of aging, iS Clinical Super Serum Advance+ is built to address all of them within a single step. It's especially well-suited for anyone who has been frustrated by brightening serums that fade surface discoloration but do nothing to improve scar texture or skin resilience.
This serum is appropriate for all skin types, including sensitive and reactive skin. The inclusion of mushroom extract, vitamin B5, and skin-conditioning actives like glycerin and urea means the formula actively supports barrier function rather than depleting it. Even if your skin tends to respond poorly to vitamin C at lower pH levels, the soothing botanicals here help offset that reactivity for most users.
If you're targeting stretch marks on the body in addition to facial concerns, this serum translates well beyond the face. It can be applied directly to any area where you want to improve tone and texture, making it a versatile addition to both a facial and body routine.
If you're applying iS Clinical Super Serum Advance+ to areas prone to dryness or flaking, warm the drops between your palms for a few seconds before pressing the serum into the skin rather than rubbing it in. This technique improves absorption and ensures even distribution over textured or scarred areas without disturbing the surface.
Prepare: Cleanse and tone skin, then ensure it is fully dry before applying.
Apply: Dispense 3 to 5 drops into your palm and smooth evenly over the face, neck, and chest. For body use on stretch marks, apply the same amount directly to the target area.
Frequency: Use morning and evening. In the morning, follow with a broad-spectrum SPF.
- Vitamin C (L-Ascorbic Acid): A powerful antioxidant with anti-inflammatory properties, which helps reduce skin redness, brighten complexion, and even skin tone.
- Calcium Pantothenate (Vitamin B5): A powerful natural moisturizer, healer, and protector that rebuilds the barrier and acts as a shield against irritation.
- Arbutin: Tyrosinase inhibitor that aids in brightening dark spots, preventing hyperpigmentation, and reducing scarring.
- Mushroom Extract: Rich in fatty acids, improves the ability of the skin to retain moisture and maintain a healthy skin barrier, while boosting collagen and calming inflammation.
- Copper Tripeptide-1: Contains three amino acids (glycine, histidine, and lysine) combined with the mineral copper. Supports healing and regeneration, boosts collagen synthesis, and delivers beneficial epigenetic messages to cells.
- Centella Asiatica Extract: Helps to strengthen and repair the skin's moisture barrier with potent anti-inflammatory benefits and antioxidant protection.
Water/Aqua/Eau, Ascorbic Acid, Hyaluronic Acid, Pentylene Glycol, Arbutin, Polyporus Umbellatus (Mushroom) Extract, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine HCI, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid
Due to the all-natural botanical extracts, the color of each batch may vary slightly!
Can I use iS Clinical Super Serum Advance+ if I have sensitive skin?
Yes. The formula includes polyporus umbellatus (mushroom) extract and calcium pantothenate (vitamin B5), both of which actively calm irritation and strengthen the skin's barrier. While the serum works at a pH of approximately 3.0 to maximize the effectiveness of ascorbic acid, the soothing botanicals in the formula help offset potential reactivity, making it well-tolerated by most sensitive skin types with consistent use.
How long does it take to see results with iS Clinical Super Serum Advance+?
Improvements in brightness and tone are typically visible within 2 to 4 weeks of twice-daily use. For raised scars, stretch marks, and deeper texture changes, expect gradual progress over 8 to 12 weeks, as tripeptide-1 works by supporting collagen synthesis and tissue regeneration, both of which are slower biological processes. Consistency is the most important variable.
Can I layer iS Clinical Super Serum Advance+ with a retinol in my evening routine?
Yes. Apply iS Clinical Super Serum Advance+ first, allow it to absorb fully, then follow with your retinol product. Both actives can complement each other for texture and tone improvement. If you notice increased sensitivity when combining them, try alternating nights until your skin adjusts.
Will iS Clinical Super Serum Advance+ help with acne scars?
Yes, and it addresses both dimensions of acne scarring. Tripeptide-1 supports tissue repair to improve the texture of raised scars, while ascorbic acid and arbutin target the residual discoloration left behind by post-inflammatory hyperpigmentation. Used consistently twice daily, this serum works on the underlying structure and surface tone at the same time.
Does iS Clinical Super Serum Advance+ need to be refrigerated?
No refrigeration is required. Store the serum in a cool, dry location away from direct sunlight to preserve potency. Because the formula contains natural botanical extracts, slight color variation between batches is normal and has no effect on performance or efficacy.
Can I apply iS Clinical Super Serum Advance+ to my body for stretch marks?
Yes. This serum is effective on stretch marks wherever they appear on the body. Apply 3 to 5 drops directly to the affected area twice daily and press gently into the skin. Visible improvement in tone and texture develops gradually over several weeks of consistent application, driven by tripeptide-1's role in collagen synthesis and tissue regeneration.
Is iS Clinical Super Serum Advance+ safe to use in the morning?
Yes, and using it in the morning is actually beneficial because ascorbic acid actively neutralizes free radicals from UV exposure and environmental pollution throughout the day, adding a layer of antioxidant defense on top of your SPF. Just make sure to follow with a broad-spectrum sunscreen every morning, both to protect your results and because vitamin C serums can increase photosensitivity.
Why buy iS Clinical Super Serum Advance+ from Art of Skin Care?
Art of Skin Care is an authorized retailer of iS Clinical, so every product you receive is 100% authentic, sourced directly through official brand channels and never from third-party resellers. Our team is made up of licensed, acne-certified estheticians who hand-select the products we carry based on real skin science and professional results. We don't just sell skincare; we understand it. Not sure if iS Clinical Super Serum Advance+ is right for your skin? Get a free skincare consultation and one of our estheticians will personally guide you.
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iS Clinical Super Serum Advance+
- Application
- Effectiveness
- Value
- Durability
- SBShelley B.Verified BuyerReviewingiS Clinical Super Serum Advance+I recommend this productHow old are you? 50-65What is your skin type? NormalWhat is your skin tone? MediumWhat are your skin concerns? AgeingRated 5 out of 5 stars5 months agoIs Clinical Super Serum Advance
My fav IS Clinical Serum. I can feel it working on my skin as soon as I apply.
Was this helpful? - JJellsVerified ReviewerReviewingiS Clinical Super Serum Advance+How old are you? 40-49What is your skin type? CombinationWhat is your skin tone? MediumWhat are your skin concerns? Ageing, Blemish-prone, Wrinkles, Sun Damage, SensitivityRated 3 out of 5 stars9 months agoNo breakouts
My esti recommended this to me, I did not realize it had vitamin C or would not have bought it because most vitamin C breaks me out. This serum is also thicker which my skin has never tolerated serums very well. This did not clog my pores or cause breakouts which was surprising but it did seem to leave me with a little redness so maybe it is too strong for me. It is also very pricey for how long it lasts, I am very minimal with how much I applied because I was nervous about breakouts with the thickness of it. If you’re not concerned with price and looking for a good product with Vitamin C it is worth trying though but I have not yet repurchased and will try something else for now.
Was this helpful? - SAStacy A.Verified BuyerReviewingiS Clinical Super Serum Advance+I recommend this productHow old are you? 50-65What is your skin type? DryWhat is your skin tone? FairWhat are your skin concerns? Ageing, Pigmentation, Wrinkles, DrynessRated 5 out of 5 stars9 months agoGreat Vitamin C+ Seum
I love how I just need a few drops daily for this superhero to nourish my skin. I put it on after my toner and give it a minute to soak in before I moisturize. It’s the rock star in my routine, because I use such a small amount it lasts for months so actually not as pricey as it seems.
Was this helpful? - MVMelissa V.Verified BuyerReviewingiS Clinical Super Serum Advance+I recommend this productHow old are you? 50-65Rated 5 out of 5 stars2 years agoiS Clinical Super Serum Advance+
Potent
My skin loves all things iS Clinical! And this serum is no exception. A potent serum that absorbs quickly and penetrates deeply. Don't let the watery consistency fool you. This serum gets to work quickly improving skin tone and texture. On my first bottle and loving the results thus far.
Was this helpful? - JAJoseph A.Verified BuyerReviewingiS Clinical Super Serum Advance+I recommend this productHow old are you? 30-39Rated 5 out of 5 stars3 years agoiS Clinical Super Serum Advance+
Powerful
I layer this under my iS Clinical Pro Youth Body Complex. Really good. It is expensive but you get what you pay for.
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