Le Mieux TGF-B Booster Serum is a healthy-aging serum built on a base of saccharomyces ferment actives and a multi-form hyaluronic acid complex to deeply hydrate, visibly firm, and reduce the appearance of fine lines and wrinkles while supporting collagen production for long-term structural improvement in the skin. Its star ingredient, palmitoyl tripeptide-5, is a bio-identical peptide that mimics the behavior of TGF-β1, a signaling protein responsible for triggering collagen synthesis deep within the skin. This serum contains fragrance.

Key Benefits

Stimulates Collagen Synthesis Palmitoyl tripeptide-5, part of the TGF proprietary formula, mimics the skin's own TGF-β1 signaling protein to trigger collagen production at a structural level, with the key peptide complex clinically shown to deliver a 119% boost in collagen synthesis.

Visibly Reduces Fine Lines and Wrinkles The peptide complex in this formula has been shown to reduce wrinkle appearance by 52% and decrease deep wrinkle depth by 7%, with cumulative results that build over consistent use.

Delivers Multi-Depth Hydration Hyaluronic acid, sodium hyaluronate, sodium hyaluronate crosspolymer, hydroxypropyltrimonium hyaluronate, and zinc hydrolyzed hyaluronate work across multiple molecular weights to attract and retain moisture at both the surface and deeper dermal layers.

Firms Skin and Targets Expression Lines Acetyl octapeptide-3 works on the repetitive muscle movements behind expression lines, while palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 support the skin's structural scaffolding for improved density and firmness over time.

Protects Against Oxidative Stress Superoxide dismutase, one of the skin's most potent endogenous antioxidants, neutralizes free radical damage, one of the primary drivers of premature collagen breakdown and visible aging.

If your skin is showing early to advanced signs of collagen loss, including fine lines, deeper furrows, or a loss of firmness, Le Mieux TGF-B Booster Serum is built for exactly that concern. It performs well across all skin types, including dry, combination, and sensitive skin, and its skin-compatible pH of 4.5 to 5.5 keeps it gentle enough for regular daily use.

This serum is also a strong choice for post-treatment skin. After a professional facial, chemical peel, or microneedling session, skin is at peak receptivity for active ingredients, and the collagen-stimulating peptides in this formula are well-positioned to work during that window.

If you're already using targeted treatments and want to amplify their effects, this booster is designed for exactly that purpose. It layers easily under or alongside other serums, making it a flexible and high-impact addition to any advanced routine.

This serum is safe for use around the eye area, just keep it away from the lash line. For a focused firming treatment at night, try pressing a small amount into skin before layering your moisturizer on top. The slight dampness left behind from toner helps the peptides absorb more effectively, so don't skip that step.

Prepare: Begin with a clean, toned face. For best results, apply while skin is still slightly damp from toner to support moisture uptake.

Apply: Dispense 3 to 5 drops into your fingertips and press evenly into the face, neck, and chest.

Technique: Use gentle pressing motions rather than rubbing to encourage absorption without disrupting the skin barrier.

Frequency: Use morning and evening. In the morning, always follow with your preferred SPF. This serum works as a standalone treatment or as a booster layered under or over other serums.