FREE U.S. SHIPPING ON ORDERS $49+

NeoGenesis Barrier Renewal Cream

NeoGenesis Barrier Renewal Cream is a lipid-rich moisturizer built to seal in hydration and reinforce a weakened skin barrier. It works two ways: as a standalone daily moisturizer for those who prefer a ceramide-rich, lipid-forward formula, or as a finishing layer over your regular moisturizer for very dry skin that needs an extra seal against transepidermal water loss (TEWL). The formula is unscented, making it comfortable for even the most reactive skin.

Key Benefits

Locks in Moisture and Reduces Water Loss A ceramide-dense lipid matrix featuring ceramide NP, ceramide AP, and ceramide EOP mirrors the skin's own protective structure to seal hydration in and keep environmental stressors out.

Repairs and Strengthens a Compromised Skin Barrier Phytosphingosine and cholesterol work alongside safflower oleosomes to replenish the intercellular lipids that hold the barrier together, helping skin recover from dryness, irritation, or post-procedure sensitivity.

Delivers Multi-Layer Hydration Sodium hyaluronate, sodium hyaluronate butyrate, sodium PCA, and glycerin attract and bind water at different depths, giving the skin sustained hydration rather than a temporary surface feel.

Soothes and Conditions Sensitive Skin Panthenol (provitamin B5) and urea calm irritation while softening rough texture, supporting skin that is dry, rosacea-prone, or undergoing oncology care.

Lightweight, Non-Greasy Finish Squalane and caprylic/capric triglyceride deliver nourishment without heaviness, so the cream layers comfortably under sunscreen or makeup without pilling.

Acne Safe

NeoGenesis Barrier Renewal Cream

Ceramide-rich barrier repair cream that seals in hydration, reduces water loss, and soothes dry, sensitive skin.
4.8
Rated 4.8 out of 5 stars
239 Reviews
Regular price $197.50
Unit price
per 
Earn points for this product!
Shipping calculated at checkout.
serum bottle icon

Primary Concerns:

  • Compromised Barrier
  • Dehydration
  • Dryness
  • Dullness
  • Redness/Rosacea
Lotion bottle icons

Best For:

  • Dry
  • Normal
  • Sensitive

NeoGenesis Barrier Renewal Cream

NeoGenesis Barrier Renewal Cream is a lipid-rich moisturizer built to seal in hydration and reinforce a weakened skin barrier. It works two ways: as a standalone daily moisturizer for those who prefer a ceramide-rich, lipid-forward formula, or as a finishing layer over your regular moisturizer for very dry skin that needs an extra seal against transepidermal water loss (TEWL). The formula is unscented, making it comfortable for even the most reactive skin.

Key Benefits

Locks in Moisture and Reduces Water Loss A ceramide-dense lipid matrix featuring ceramide NP, ceramide AP, and ceramide EOP mirrors the skin's own protective structure to seal hydration in and keep environmental stressors out.

Repairs and Strengthens a Compromised Skin Barrier Phytosphingosine and cholesterol work alongside safflower oleosomes to replenish the intercellular lipids that hold the barrier together, helping skin recover from dryness, irritation, or post-procedure sensitivity.

Delivers Multi-Layer Hydration Sodium hyaluronate, sodium hyaluronate butyrate, sodium PCA, and glycerin attract and bind water at different depths, giving the skin sustained hydration rather than a temporary surface feel.

Soothes and Conditions Sensitive Skin Panthenol (provitamin B5) and urea calm irritation while softening rough texture, supporting skin that is dry, rosacea-prone, or undergoing oncology care.

Lightweight, Non-Greasy Finish Squalane and caprylic/capric triglyceride deliver nourishment without heaviness, so the cream layers comfortably under sunscreen or makeup without pilling.

NeoGenesis Barrier Renewal Cream

4.8
Rated 4.8 out of 5 stars
Based on 239 reviews
Total 5 star reviews: 207 Total 4 star reviews: 21 Total 3 star reviews: 11 Total 2 star reviews: 0 Total 1 star reviews: 0
Reviews Summary
Customers say this cream provides excellent hydration while maintaining a lightweight feel. Many reviews mention its effectiveness for dry skin without causing breakouts. The cream absorbs quickly and works well for both day and night use. While some note it's particularly beneficial during winter months, others find it suitable year-round. Reviews frequently highlight its gentle nature on sensitive skin and its ability to layer well with other products. Though most praise its moisturizing qualities, some mention the high price point as a concern. Common feedback includes its smooth texture and non-greasy finish. Several users appreciate how it helps maintain skin moisture throughout the day.
Customers Talked About
239 reviews
  • TB
    Theresa B.
    Verified Buyer
    Reviewing
    NeoGenesis Barrier Renewal Cream
    I recommend this product
    How old are you? 50-65
    What is your skin type? Dry
    What is your skin tone? Fair
    What are your skin concerns? Ageing, Dryness, Sensitivity, Pigmentation
    Rated 5 out of 5 stars
    3 weeks ago
    I love this cream

    I have been through many bottles of this and sometimes stray but always come back to it. It is not heavy but not too light either.

  • JC
    John C.
    Verified Buyer
    Reviewing
    NeoGenesis Barrier Renewal Cream
    I recommend this product
    How old are you? Over 65
    What is your skin type? Combination
    What is your skin tone? Fair
    What are your skin concerns? Redness, Wrinkles, Pigmentation, Ageing
    Rated 5 out of 5 stars
    1 month ago
    Outstanding Barrier cream

    this is such an amazing product . Neogensis stem cell ingredients do work to smooth skin lines and calm rosacea on my checks.

  • GH
    Gabrielle H.
    Verified Buyer
    Reviewing
    NeoGenesis Barrier Renewal Cream
    I recommend this product
    How old are you? 18-29
    What is your skin type? Combination
    What is your skin tone? Fair
    What are your skin concerns? Blemish-prone, Sensitivity, Wrinkles, Acne
    Rated 5 out of 5 stars
    1 month ago
    Nice and creamy

    I like to put this moisturizer on top of my regular day and night cream. It was referred to me by one of the art of skin care aestheticians. I feel like it gives me the extra boost of hydration that I need on days when my skin is really dry.

  • CR
    Clorinda R.
    Verified Buyer
    Reviewing
    NeoGenesis Barrier Renewal Cream
    I recommend this product
    How old are you? Over 65
    What is your skin type? Normal
    What is your skin tone? Medium
    What are your skin concerns? Ageing
    Rated 5 out of 5 stars
    1 month ago
    Rich moisturizer

    I use at night as the last step in my skincare and my skin drinks it up.

  • MD
    Mariah D.
    Verified Buyer
    Reviewing
    NeoGenesis Barrier Renewal Cream
    I recommend this product
    How old are you? 30-39
    What is your skin type? Combination
    What is your skin tone? Fair
    What are your skin concerns? Acne, Ageing, Pigmentation, Wrinkles, Sensitivity
    Rated 5 out of 5 stars
    4 months ago
    Great cream

    Moisturizing and gentle. Love NeoGenesis for their effective and fragrance free formulas.