Senté Dermal Repair Cream is a clinically proven anti-aging moisturizer accepted by the National Rosacea Society and formulated for all skin types, including sensitive, rosacea-prone, and post-treatment skin. Powered by Senté's patented Heparan Sulfate Analog (HSA), the first and only topical HSA shown in peer-reviewed clinical studies to visibly repair skin at a cellular level, it reduces visible redness, improves the appearance of fine lines, promotes barrier health, and delivers deep hydration in a single daily moisturizer. Dermatologist-tested, hypoallergenic, and free of fragrance, parabens, and gluten, it is the cornerstone product of the Senté skincare system.

Key Benefits

Reduces Visible Redness and Calms Reactive Skin
In a Senté clinical study, 70% of subjects with sensitive skin showed reduced redness within 4 weeks, and 79% reported their skin felt less sensitive and reactive within 2 weeks.

Repairs Skin at the Cellular Level with Patented HSA
Heparan Sulfate Analog is the only topical ingredient shown in peer-reviewed studies to support growth factor regulation and cellular communication, driving repair that surface-level ingredients cannot replicate.

Visibly Reduces Fine Lines and Wrinkles
Consistent use produces measurable improvements in fine lines and wrinkles by supporting collagen and elastin synthesis through HSA's growth factor signaling pathway.

Strengthens and Restores the Skin Barrier
HSA reduces transepidermal water loss and improves the skin's ability to defend itself against environmental stressors, making it one of the most effective barrier-repair moisturizers available without a prescription.

Fades Uneven Tone and Dark Spots
Acetyl Glucosamine inhibits melanin production at the source, working alongside HSA to visibly improve skin tone, reduce hyperpigmentation, and create a more even complexion over time.

Delivers Deep, Non-Greasy Hydration
Argan oil, hyaluronic acid, and green tea extract provide sustained moisture throughout the day and overnight, leaving skin plump, comfortable, and luminous.

In a clinical study by Sente:

• 70% of subjects with sensitive skin showed reduced redness in 4 weeks
• 79% of subjects with sensitive skin agreed their skin was less sensitive and reactive in 2 weeks

Sente Dermal Repair Cream is for anyone ready to invest in a moisturizer with real clinical evidence behind it. If you are concerned about fine lines, early signs of aging, uneven texture, or barrier compromise and want a product that addresses all of those concerns simultaneously, this is the product that Sente built its reputation on.

It suits all skin types, including dry, normal, combination, sensitive, and mature skin. Because HSA is a naturally occurring compound that the skin already recognizes, it is exceptionally well tolerated, including by those with rosacea, post-procedure sensitivity, or reactive skin that cannot use retinol or acid-based anti-aging treatments.

This cream is also an ideal entry point for anyone new to Sente, as it demonstrates the brand's technology clearly and visibly, and it pairs with every other product in the Sente lineup without adjustment.

For dry skin types, I recommend Senté Dermal Repair Ultra-Nourish in place of Dermal Repair Cream. It delivers the same patented HSA technology in a richer, more occlusive formula specifically designed for skin that needs deeper nourishment. Apply it to slightly damp skin right after your serum has absorbed for best results.

Prepare: Apply to clean skin morning and evening as the moisturizing step in your routine, after serums and before SPF in the morning.

Apply: Dispense a pea- to dime-sized amount and warm between fingertips. Press and blend gently across the face, neck, and décolleté.

Technique: Use upward pressing motions and allow the cream to absorb fully before applying sunscreen. For enhanced results, apply to slightly damp skin to improve absorption of HSA.

Frequency: Use twice daily, morning and evening, without exception. Clinical results are based on consistent twice-daily use, and twice-daily application is what drives the cumulative repair effects of HSA technology.