Acne is one of the most common skin challenges in the U.S., and it’s not just limited to teenagers. In fact, it impacts all ages, races, and genders. Nearly 60 million Americans have active acne and 20 million are at risk of developing scar tissue as a result.
If you are looking for assistance in achieving clear skin, we recommend participating in our online Acne Consultation.
What Is Benzoyl Peroxide?
Benzoyl peroxide (BPO) is a white or off-white water-soluble crystalline powder in the organic peroxide family that has been used in acne treatment formulas for more than 80 years. It works as a bleaching and peeling agent, is antimicrobial, increases cell turnover, reduces bacterial count, clears up existing acne, and prevents future breakouts.
Benzoyl peroxide offers the following benefits:
- It peels skin like salicylic or resorcinol, reducing blockages.
- It kills the bacterium Propionibacterium acnes (P.acnes).
- It has anti-inflammatory properties that reduce pain and discomfort associated with many lesions.
- It eliminates fatty acids and oils in the skin.
Things You Should Know About Using Benzoyl Peroxide and Face Reality Acne Med:
Expect to be a bit dry!
Benzoyl peroxide can be extremely irritating and drying. During the initial weeks, you may experience some dryness, redness, itching, flaking, tightness, or mild peeling. This is temporary and will subside as your skin adapts. Those who can push through the initial dryness and light flaking will see the fastest results. However, if you are uncomfortably dry or have a dark skin tone, let us know. We can offer some helpful tips for getting through the dry phase.
Recommended use in the PM
We have found the best success with using benzoyl peroxide in the evening, as our bodies do their best healing while we sleep! There are times when Acne Med is used in the morning with a "timed method," but we suggest connecting with one of our licensed Acne Coaches to decide if this is best for you.
Avoid eye area and lower neck
Do not use benzoyl peroxide on your neck or eye area as it can over-dry and irritate the delicate tissue in these areas.
No eye cream in the PM
Do not use eye cream around the eyes as the benzoyl peroxide will migrate through the cream and cause irritation and possible swelling. Instead, choose a water-based eye gel or serum and apply before applying your Acne Med.
Can you use moisturizer with BPO?
Acne-Safe moisturizers can be used over your Acne Med; simply wait 10 to 15 minutes before applying. Additionally, those who need extra hydration in the PM can apply a water-based hydrating gel or serum under Acne Med.
Our favorite nourishing gels and serums to use under Acne Med:
The products at Art of Skin Care, which are safe for blemish-prone skin, have an acne-safe badge to help you choose wisely.
Our favorite acne-safe moisturizers:
Our favorite acne-safe moisturizers from lightest to heaviest:
Avoid eye irritation
If your eyelids get irritated, try changing your pillowcase more often. When wearing Acne Med at night, it will transfer to the pillowcase. Some clients prefer to apply a thin layer of Sorella Apothecary Salving Grace Recovery Ointment to the eye area before using Acne Med, to prevent benzoyl peroxide from traveling and reaching the delicate eye area.
Smile lines
The area around the mouth tends to be the most sensitive area on the face and will be the first place you notice irritation and dryness. You can apply a very thin layer of Sorella Apothecary Salving Grace Recovery Ointment this area for a few days, then resume regular product use.
Working out? Remove benzoyl peroxide
Do not wear benzoyl peroxide when you expect to perspire. If you plan to exercise, engage in physical labor, or be outside in the sun, be sure to fully remove your Acne Med to avoid irritation.
Will bleach fabric
Benzoyl peroxide can bleach fabrics. Use white towels and linens when applying your Acne Med, and wear an old T-shirt to bed if treating body acne. Always wash your hands thoroughly after application to prevent bleaching towels or clothing.
Allergic reaction
Allergies to benzoyl peroxide are rare but do occur occasionally. Dry skin does not constitute an allergic reaction. An allergy is characterized by itching, swelling, or burning associated with a rash similar to a mild case of poison ivy dermatitis.
If irritation occurs, rinse the affected area with cool tap water to soothe the skin and reach out to us. We can help you determine if it is an allergy and devise an alternate treatment plan.
Diligence pays off
Skipping even a day or two—or only spot treating—creates an opportunity for acne to develop. Consistency is key: Stick with your home care treatment plan every day to see and keep your results.
Use over the entire acne-prone area
While spot treating can be effective for those who are mildly blemish-prone, those with more severe inflamed acne must use benzoyl peroxide serum over the entire acne-prone area every day. This is what will help prevent future breakouts.
Be sure to apply SPF
Benzoyl peroxide increases sun sensitivity, so it is vital to add sun protection into your daily routine.
FAQ
If you’re new to benzoyl peroxide, these expert-backed answers will help you use it safely and effectively for clear, balanced skin.
What is benzoyl peroxide and how does it work?
Benzoyl peroxide is an antibacterial ingredient that kills acne-causing bacteria (Cutibacterium acnes) and helps unclog pores by reducing excess oil and dead skin buildup. It’s one of the most effective over-the-counter treatments for inflammatory acne like pustules and papules.
What percentage of benzoyl peroxide should I use?
Most people see results with concentrations between 2.5% and 5%. Higher percentages (10%) don’t necessarily work better—they can increase irritation and dryness. For sensitive skin or first-time users, start with 2.5% and build up as tolerated.
How often should I use benzoyl peroxide?
Start with once a day or every other day in the evening. Once your skin adjusts, you can use it nightly. Overuse can lead to dryness or peeling, so listen to your skin and moisturize well.
Should I use benzoyl peroxide all over my face or just on breakouts?
Apply it as a thin, even layer over the entire acne-prone areas, not just on active pimples. This helps prevent new breakouts by keeping pores clear and reducing acne bacteria across the skin.
Can I use benzoyl peroxide with other acne treatments like salicylic acid or retinol?
Yes—but with caution. Using too many actives at once can irritate the skin. Pair benzoyl peroxide with hydrating or barrier-supporting products and alternate use with acids or retinoids on different nights (a “skin cycling” approach). Always patch-test new combinations.
Does benzoyl peroxide bleach towels or clothing?
Yes. Benzoyl peroxide can oxidize and bleach fabrics, especially darker materials. Use white towels and pillowcases, and let the product fully absorb before dressing or going to bed.
ow long does it take to see results with benzoyl peroxide?
You may notice improvement within 2 to 4 weeks, but full clearing can take 8 to 12 weeks of consistent use. Acne often purges before it improves, so patience and consistency are key.
Can I use benzoyl peroxide if I have sensitive skin?
Yes, but start slowly. Choose a low concentration (2.5%), apply to clean, dry skin, and follow with a calming moisturizer. If irritation occurs, reduce frequency or layer a barrier serum underneath—like Face Reality Hydrabalance Hydrating Gel or Hale & Hush Hydrate Gel.
Should I moisturize after using benzoyl peroxide?
Absolutely. A lightweight, acne-safe moisturizer restores balance and prevents over-drying. Look for soothing ingredients like ceramides, niacinamide, or panthenol.
What’s the difference between benzoyl peroxide and salicylic acid?
Benzoyl peroxide kills acne bacteria and clears infection, while salicylic acid exfoliates inside pores to prevent clogs. The best acne routines often combine both, using benzoyl peroxide to treat breakouts and salicylic acid to prevent new ones.
Can I use benzoyl peroxide during the day?
We recommend using benzoyl peroxide during the day as a spot treatment only, always followed by a broad-spectrum SPF 30+. Because benzoyl peroxide can increase sun sensitivity, daily sunscreen is essential to protect the skin and prevent post-inflammatory hyperpigmentation.
What are the side effects of benzoyl peroxide?
Common side effects include mild dryness, flaking, or redness, especially during the first few weeks. Severe irritation, burning, or swelling means the product is too strong or used too often—reduce frequency or switch to a lower strength.
When should I stop using benzoyl peroxide?
If your acne clears but you still get occasional breakouts, you can reduce use to a maintenance schedule (3–4 times per week).
Is benzoyl peroxide safe for hormonal or adult acne?
Yes. Benzoyl peroxide treats all acne types caused by bacteria and clogged pores, making it effective for teen and adult acne, including hormonal breakouts on the chin and jawline.
Can I use benzoyl peroxide with makeup?
Yes, you can wear makeup with benzoyl peroxide—just be sure to apply the treatment first, allow it to absorb completely, and choose acne-safe, non-comedogenic makeup to avoid clogging pores. Keep in mind that acne cosmetica (breakouts caused by makeup) can take up to five weeks to appear, so a product that seems fine today may be contributing to future breakouts.
Click to start Lesson 1 in the Acne Learn Center
LEARN more about using Moisturizer with Benzoyl Peroxide
Author
Celine LeClerc is a licensed esthetician, Certified Acne Specialist, and the lead esthetician at Art of Skincare, where she also serves as the Director of Education and Research & Development. With 14 years of experience in the skincare industry, Celine is renowned for her deep expertise and exceptional ability to match clients with the most effective, results-driven skincare solutions.
Guided by a passion for innovation, Celine scours the globe in search of cutting-edge, science-backed products that deliver visible transformations while supporting skin health at every stage of life. Her expertise spans everything from clearing stubborn acne to creating advanced, holistic routines for healthy aging.
At Art of Skincare, Celine leads with a commitment to education, training both clients and estheticians on the latest advancements in skincare. Her mission is to empower individuals with the knowledge, tools, and routines they need to achieve radiant, resilient skin without compromise.