Skinbetter Science® Skincare

skinbetter science® is a professional strength skincare brand built on patented technology and clinical research, available exclusively through authorized aesthetic professionals. Founded by the team behind Medicis Pharmaceutical Corporation, a leader in pharmaceutical-grade aesthetic medicine, it is now part of the L'Oréal Dermatological Beauty family. The brand is known for streamlined routines that deliver visible, clinically validated results.

For clients who want professional strength results without in-office procedures, skinbetter science consistently delivers. Clinical trials show measurable improvements in tone, texture, firmness, and fine lines, and its patented technologies outperform standard over-the-counter formulas. Most clients find that two to three well-chosen products are enough to make a meaningful difference.

AlphaRet® is a patented molecule that conjugates a retinoid with an alpha hydroxy acid, delivering retinoid-level results with significantly less irritation than traditional retinol. Clinical studies show AlphaRet achieves comparable or superior results to retinol with a better tolerability profile, making it ideal for those who have struggled with standard retinoids.

InterFuse® is a patented delivery system that carries high-performance ingredients, including peptides and hyaluronic acid, deeper into skin than standard topical application allows. It is the technology behind the InterFuse product line, which targets visible firmness loss, deep expression lines, and the eye area.

Most estheticians recommend starting with two products: the Alto Advanced Defense and Repair Serum in the morning and the AlphaRet Overnight Cream at night. This combination addresses the most common concerns, including tone, texture, fine lines, and environmental protection, and forms the foundation of a complete professional strength routine.

Both use the AlphaRet® retinoid-AHA technology, but the Intensive version contains a higher concentration of glycolic acid for more advanced resurfacing. The standard AlphaRet Overnight Cream is the recommended starting point; the Intensive is best for those who have already tolerated the original formula well and want stronger results.

Yes! All skinbetter science products have been tested and proven in clinical trials to be acne safe and non-comedogenic.

skinbetter science is only sold through authorized aesthetic professionals to ensure product authenticity, proper storage, and expert guidance. As professional strength formulas, these products perform best when paired with an esthetician who can match the right products to your skin. Unauthorized sellers, including some marketplace sites, carry a risk of counterfeit or improperly stored product. Art of Skin Care is a fully authorized retailer and every product we carry is genuine. Start a complimentary consultation with one of our estheticians and we'll build the right skinbetter science routine for your skin.

Yes. All skinbetter science products are dermatologist-tested, fragrance-free, paraben-free, dye-free, and cruelty-free. The AlphaRet technology is specifically designed to reduce the irritation associated with retinoids, and the Trio Rebalancing Moisture Treatment, which holds the National Rosacea Society Seal of Acceptance, is formulated for reactive and rosacea-prone skin.

We recommend consulting your OB-GYN before using any retinoid-containing products, including AlphaRet, during pregnancy or while breastfeeding. Products without retinoids, such as the Alto Advanced Defense and Repair Serum, Trio Rebalancing Moisture Treatment, and sunbetter SPF, are generally considered lower-risk, but your provider should make the final determination.